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조광현(Kwang Hyun Cho),이유신(Yoo Shin Lee) 대한피부과학회 1984 大韓皮膚科學會誌 Vol.22 No.4
A clinical study was made on 148 cases of cutaneous malignant tumors that visited the Department of Dermatology at Seoul National University Hospital during a 11-year period from 1973 to 1983. The results were summarized as follows: 1) The incidence of cutaneous malignant tumors in the total number of outpatients visiting the Department of Derrnatology was 0. 025g. 2) There were 90 cases of male (60. 8p,) and 58 cases of female (39. 2g). The ratio of male to female was l. 55: l. Among the 148 cases of cutaneous malignant tumors, the most frequently observed type was basal cell carcinoma, 58 cases (3j.2 p:). The next most frequent types were squamous cell carcinoma, 42 cases(28. 4g) and malignant melanoma, ]1 cases (7. 4g). We described the clinical characteristics of the patients with basal cell carcinoma, squamous cell carcinoma and malignant melanoma that have been observed.
조광현(Kwang Hyun Cho),강승주(Seung Joo Kang),이유신(Yoo Shin Lee),김철우(Chul Woo Kim) 대한피부과학회 1986 대한피부과학회지 Vol.24 No.6
We report a case of angiosarcoma of the face and scalp in a 76-year-old man. Immunochemical staining with factor 8-related antigen and ultrastructural find ings confirm that this tumor was origined from endothelium. The patient had a good initial response to treatment with radiotherapy.
조광현(Kwang Hyun Cho),이유신(Yoo Shin Lee),함의근(Eui Keun Ham) 대한피부과학회 1985 大韓皮膚科學會誌 Vol.23 No.2
A statistical survey was made on 737 cases of cutaneous benign tumors that visited the Department of Dermatology at Seoul National University Hospital during a 11-year period from 1973 to 1983. The results were summarized as follows: 1) There were 329 cases of male(44. 6%) and 408 cases of female(55. 4%). The ratio of male to female was 1: l. 24. 2) Most patients with cutaneous benign tumors belonged to age ranged from 10 to 39 with the highest incidence in the 3rd decade. 3) According to Levers classification, 737 cases of cutaneous benign tumors were divided into following 6 groups: tumors and cysts of the epidermis(252 cases, 34, 2 tumors of the epidermal appendages(125 cases, 17.0%), tumors of fibrous tissue(98 cases, 13.3%), tumors of vascular tissue(158 cases, 21.4%), turnors of farty, muscular and osseus tissue(37 cases 5.0%), tumors of neural tissue(67 cases, 9. 1 %). 4) The distribution of the frequently observed cutaneous benign tumors was as fo]lows: epidermal cyst(12. 1%), nevus flammeus(11. 4%), neurofibroma(9, l%), linear epidermal nevus(7. 9%), syringoma(6, 6%), seborrheic keratosis(7. 9%.). nevus sebaceus(6. 0%), dermatofibroma(5. 8%), steatocystoma multiplex(4. 1%,), tuberous sclerosis(2. 8% ), granuloma pyogenicurn(2. 8%).
조광현,송계용,조미경,이유신,함의근 ( Kwang Hyun cho,Kye Yong Song,Mi Kyung Cho,Yoo Shin Lee,Eui Keun Ham ) 대한피부과학회 1988 大韓皮膚科學會誌 Vol.26 No.3
A histopathological study of erythema nodosum-like lesions in Behcet's disease was performed on 55 patients with incomplete and suspect types of Behcet's disease. Relatively common characteristics in histopathology of erythema nodosum-like lesions could be found in the patients with incomplete type of Behcet's disease. The histopathologic findings of erythema nodosum-like lesions in 21 patients with incomplete type of Behcet's disease were as follows : l. A moderate lymphocytic infiltration was found around the blood vessels and the sweat glands in the dermis. In the subcutaneous tissue, besides lymphohistiocytic infiltration, neutrophils were present in significant number in 9 cases (42.9%) 2. Vasculitis of small vessels was found within the periphery of fat lobules in 7 cases (81.0%), Five cases (23.8%) also showed thrombophlebitis. Seven cases (33.3%) showed histiocytic granuloma formation within the fat lobules. Microabscess formation in the subcutaneous tissue was seen in 5 cases (23.8 %), but it was not certain whether this was the charateristic feature.
조광현(Kwang Hyun Cho),이주홍(Joo Heung Ree),이유신(Yoo Shin Lee),한성구(Sung Koo Han) 대한피부과학회 1988 대한피부과학회지 Vol.26 No.4
We report a 58 year old man who complained that his nails didn't grow for a year and developed yellowish discoloration. On physical examination his nails showed yellow greenish discoloration, increased corvexity, loss of lunulae and cuticles. C]iest X ray revealed atelectasis on right lower lung field and bronchiectasis on left lower lung field. Mild restrictive pattern was observed in pulmoniry function test. We gave him 800IU of Vitamin E claily for 3 months, but rio remarkable changes have been observed as yet..
만성 알코올 급여 흰쥐에서 보리 추출물 섭취가 Cytochrome P450 효소 조절 및 항산화계에 미치는 영향
이유현(Yoo-Hyun Lee),이정민(Jeongmin Lee),임은정(Eun-Jeong Im),전우진(Woojin Jun),조홍연(Hong Yon Cho) 한국식품영양과학회 2009 한국식품영양과학회지 Vol.38 No.10
본 연구에서는 보리 추출물을 이용하여 알코올 유도 P450 계열 효소 활성을 조절함으로써 라디칼 및 중간체의 발생감소와 항산화 효소의 활성증강에 의한 보호효과를 연구하였다. ICR mice를 대상으로 대조군(Control), 알코올군(EtOH), 알코올-보리 추출물 급여군(EtOH-B)으로 나누어 전체 열량의 35%에 해당하도록 조성된 알코올 액체 식이를 알코올군 및 알코올-보리 추출물 급여군에 28일 간 공급하였다. 알코올 투여군은 P450 함량에 있어서 대조군에 비하여 급격한 증가를 보였으며, 알코올-보리추출물 급여군은 대조군 수준으로 유의적인 감소를 하였다. 알코올 유도 CYP2E1, CYP1A2는 알코올군에서는 유의적인 증가를 보였으며, 알코올-보리 추출물 투여군에서 이들 효소의 활성을 유의적으로 억제시키는 결과를 확인할 수 있었다. 생체 내 방어시스템의 변화 면에서 알코올 급여군에서 급격하게 감소한 catalase 활성이 보리 추출물 급여군에서는 유의적으로 증가하여, CYP2E1의 활성억제에 의한 라디칼 발생 저하를 확인할 수 있었다. 이상의 실험 결과로서, 보리 추출물은 알코올 유도 CYP2E1, CYP1A2 효소 활성의 억제와 생체 내 방어 기작의 효과적인 활성화에 의하여 알코올성 간 손상의 개선 소재로 활용가능 할 것이라고 사료된다. The effects of methanol extract of barely (Hordeum vulgare) on alcohol-induced damages of liver were investigated in male ICR mice. Mice were divided into three groups, control, ethanol, and ethanol plus 0.15% of barley extract. After four weeks of ethanol feeding, ethanol group significantly increased the P450 content, CYP2E1 and CYP1A2 enzyme activities, whereas ethanol plus barely group markedly decreased to levels similar to control group. Catalase activity in ethanol group was significantly lower than that in control group; however, ethanol plus barely group stimulated catalase activity as well as SOD activity significantly. These results indicated that barely extract modulated P450 enzymes for ethanol-induced liver damage and might be useful in developing functional food for alcoholic liver damage.
가자(Terminalia chebula Retz.) 열매 메탄올 추출물의 Histone Acetyltransferase 활성 저해에 따른 항전립선암 효과
이유현(Yoo-Hyun Lee) 한국식품영양과학회 2013 한국식품영양과학회지 Vol.42 No.10
본 연구에서는 Terminalia chebula Retz.의 성숙열매인 가자 메탄올 추출물(TCME)을 이용하여 HAT 활성을 억제함으로써 AR의 아세틸화 감소를 유도하여 전립선암세포의 성장을 억제하였다. TCME의 처리는 HAT 활성을 100 μg/mL의 농도에서 50% 이상 저해하였으며, p300과 CBP 등의 특이적 HAT 단백질에서도 유의적인 저해활성을 보였다. TCME를 0~100 μg/mL로 안드로젠 수용체 의존적 전립선 암세포인 LNCaP에 처리한 결과, reporter assay에서 AR 매개 전사를 억제하고 AR target gene의 mRNA 발현을 억제하였다. 동일 농도에서 AR의 아세틸화가 감소한 결과를 보였으며, 결국 전립선암세포주의 성장억제를 유도하였다. 이같은 결과에서 가자 메탄올 추출물은 HAT 활성을 억제하며, AR의 아세틸화를 감소시킴으로써 효과적인 전립선암 치료소재로 개발될 수 있는 가능성이 있음을 제안한다. The inhibitory effect of histone acetyltransferase from methanol extract of Terminalia chebula Retz.fruit (TCME) was investigated in prostate cancer cell. TCME significantly inhibited histone acetyltransferase (HAT) activity by over 50% at 100 μg/mL concentration. TCME treatment repressed androgen receptor (AR) mediated transcription, mRNA level of AR target genes, prostate specific antigen (PSA) and NKX-3.1, as well as AR acetylation. Finally, the prostate cancer cell viability was dramatically reduced by TCME treatment at 0~100 μg/mL concentration. These results indicated that TCME, as a potent HAT inhibitor, could suppress prostate cancer cell growth by AR mediated transcription regulation.
원발성 피부 유전분증에서 항케라틴 단세포군 항체를 이용한 유전분의 면역조직화학 염색
조광현(Kwang Hyun Cho),장승호(Seung Ho Chang),김정애(Jeong Aee Kim),이유신(Yoo Shin Lee),함의근(Eui Keun Ham) 대한피부과학회 1990 대한피부과학회지 Vol.28 No.3
Nine cases of primary localized cutaneous amyloidosis were studied by immunoperoxidase technique (ABC method) employing anti-keratin antibodies. All specimens were examined using consecutive paraffin sections to confirm the correspondence between amyloid existing area and reactive sites. Anti-keratin antibody 34pE which recognize 68, 58, 56.5, 56kd keratin peptides reacted with amyloid deposits in both lichen amyloidosus and macular amyloidosis. However, anti-keratin antibodies 34pB4 and 35pH did not react with amyloids. In general, Dylon staining positive material, keratin reacted with 34pE and amyloid P showed similar distribution in serial sections, but did not show the same one. Several keratin bodies reacted with 34pE, which were not stained with Dylon staining or antiamyloid P were found in the dermis of one specimen. These results suggest that immunohistochemical staining with antikeratin antibody 34pE using formalin-fixed, paraffin-embedded sections appeared to be a useful method in studying the histogenesis of primary localized cutaneous arnyloidosis. (Kor J Dermatol 28(3): 308 314, 1990)