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지속형 천식 환자에서 아콜레이트 (R) ( Zafirlukast ) 투여에 따른 유효성과 안전성 및 내약성 평가를 위한 비대조 , 다기관 임상연구
최병휘(B . W . Choi),최인선(I . S . Choi),박춘식(C . S . Park),민경업(K . U . Min),이양근(Y . K . Lee),김능수(N . S . Kim),홍천수(C . S . Hong),박중원(J . W . Park),조영주(Y . J . Cho),윤호주(H . J . Yoon),박해심(H . S . Park) 대한천식알레르기학회 2001 천식 및 알레르기 Vol.21 No.3
Background and Objective:Accolate, one of the cysteinyl leukotriene receptor antagonists, have anti-inflammatory and bronchodilating effects. The clinical indications for LT antagonist are not yet in consensus. We performed a non-comparative multicenter trial to assess the additional responses of Accolate to the current long-term control regimens in persistent asthma. Materials and Methods: Eighty persistent asthmatics from 10 asthma special care clinics were enrolled. Daily 20 mg of Accolate was added 2 times to the current control regimen for 6 weeks and its effects on symptom scores, morning and evening PEFR, FEV1, and frequency of the short acting 2 agonist usage for relief of asthma were measured. Results: The morning symptom scores significantly improved by addition of Accolate for 1 week (p<0.01) and its effect persisted to the 6th week (p<0.01) of trial. Nocturnal symptom scores also improved at 2nd week (p<0.05) and the effect continued to the end of this trial. Days with morning asthma symptoms decreased by addition of Accolate at 4th week (p<0.05) and 6th week (p<0.05). The frequency of the short acting β2 agonist inhalations significantly decreased by addition of Accolate from 1st week to the end of this trial. Morning and evening PEFR significantly improved at 1st week and the effects progressively improved to the end of this trial. The FEV1 not improve by addition of Accolate. However, when the asthmatic with obstructed lung function (FEV1 <80%) were enrolled only for analysis, the FEV1 significantly improved at 3rd (p<0.05) and 6th weeks (p<0.05). In 21 asthmatics, oral prednisolone was continuously used at the beginning of this trial. It could be discontinued in 4 patients and the dosage of prednisolone was significantly reduced in another 3 patients by addition of Accolate. Their mean administered dosage of prednisolone decreased from 8.6±0.9 mg/day to 6.8±1.1 mg/day at the end of this trial (p<0.05). Conclusions: With these results, we thought that addition of Accolate as a long term control regimen in the symptomatic persistent asthmatics would be an effective strategy. For evaluation of steroid sparing effects, further studies will be needed. (J Asthma Allergy Clin Immunol 21: 552-560, 2001)
소방이 형성된 늑막질환에서의 늑막강 내 유로키나제 주입 효과
최수미(Soo Mi Choi),이용철(Yong Chul Lee),이양근(Yang Keun Rhee) 대한내과학회 1994 대한내과학회지 Vol.46 No.2
Background: Adequate pleural drainge is believed to be essential component of the management of loculated pleural effusion. This study was designed to evaluate the therapeutic effectiveness of urokinase instillation for the resolution of loculated pleural effusion caused by bacterial or tuberculous empyema, we inserted pig-tail catheter (8~12Fr) into the dependent position of cavity under the guide of fluoroscopy and ultrasonography. Method: Intrapleural urokinase was used in 12 patients with relatively large, symptomatic, loculated pleural effusion when inadequate drainage was demonstrated roentgenograpically despite of good positioned tube. A solution of urokinase 100,000 U in 100 mL normal saline was insilled into the pleural cavity via a percutaneous drainage catheter. Effectiveness of intrapleural urokinase was assessed radiographically and by monitering the volume of fluid drained from the chest tube after urokinase instillation. Result: A greater than 75% improvement in the CXR was seen eleven of 12 patients after third intrapleural administration of urokinase. The volume of fluid out in the first 48 hour post-urokinase was 378.3±103.1mL (range; 140 to 510). In addition, clinical improvement (decreased chest discomfort, less dyspnea and reduced fever) was noted in ten of 12 patients after urokinase treatment. Conclusion: The result suggest that the urokinase instillation into the loculated pleural effusion is very effective in shortening the treatment duration of loculated pleural effusion, and it is considerd to be carried out in initial step of therapeutic interventions.
폐암 환자에서 혈청 sICAM - 1 , sVCAM - 1 and sE - selectin 농도의 변화
최상인(Sang In Choi),이흥범(Heung Bum Lee),이용철(Yong Chul Lee),이양근(Yang Keun Rhee) 대한내과학회 1998 대한내과학회지 Vol.54 No.6
Background: Leukocyte-endothelial adhesion molecules have been implicated in inflammatory and immune responses of several diseases. Of these adhesion molecules, elevated sICAM-1 level in circulation was reported as association with liver metastasis in gastric, colonic, gall bladder or pancreatic cancer, and with reduced survival in malignant melanoma. However, there were extremely few studies about the sVCAM-1 and sE-selectin levels in lung cancer cell lines of various histologic types and staging. This study was performed to measure the sICAM-l, sVCAM-1 and sE-selectin in patients with lung cancer, and to analyze the relation between the staging of lung cancer and level of adhesion molecules. Methods: Fifty nine lung cancer patients and eight normal controls were enrolled in the study. sICAM-1, sVCAM-1 and sE-selectin in the serum were measured using each murine monoclonal antibody by ELISA. Results: sICAM-1 levels were significantly higher in patients with non small cell lung cancer than in normal controls and those were more elevated in advanced and distant metastatic groups. In case of small cell lung cancer, sICAM-1 levels were significantly higher in extensive stage than limited stage. There were no differences in sVCAM-1 and sE-selectin levels between the patients with lung cancer and normal control. Conclusion: These results suggest that sICAM-1 among the serum soluble adhesion molecules may reflect the progression and metastasis in the patients with non small cell lung cancer
다이프로피온산 베클로메타손과 부데소니드의 투여 용량에 따른 코르티솔 농도와 변화
이영승(Y . S . Lee),최수미(S . M . Choi),송하숙(H . S . Song),김종구(J . K . Kim),이용철(Y . C . Lee),이양근(Y . K . Rhee) 대한내과학회 1993 대한내과학회지 Vol.45 No.6
Background: Topical inhaled steroids, budesonide (Bu) and beclomethasone dipropionate (BDP) is now established in the management of chronic: asthma. These have high topical anti-inflammatory activity but low systemic activity. This study was performed to determine the effects of two inhaled corticosteroids, Bu and BDP, on the adrenocortical supression in thirty patients, eighteen chronic obstructive pumonary diseases and twelve bronchial asthma (aged 33-76 years). Methods: The adrenocortical function was assessed by measurement of plasma cortisol concentration at 8 o' clock in morning and free cortisol in 24-hour urine collection at interval, No steroid was taken during the pretreatment period of 10 days, thereafter each subject inhaled Bu or BDP aerosol, in daily doses of 800 or 1,600 micrograms for 12 days. The dose was delieved by metered dose inhaler (MDI) or diskhaler. No steroid was taken during the final 6 days of the study. Results: The plasma cortisol and 24-hour urinary free cortisol were decreased during the treatment period in patients inhaled Bu in daily doses of 800 and 1,600 micrograms. In contrast, plasma cortisol was decreased on the 12th day of treatment period in patients inhaled RDP, in daily doses of 800 micrograms (P less than 0.05). The plasma cortisol and 24-hour urinary free cortisol were decreased (P less than 0.05) on the 9 and 12 th day of treatment period in patients inhaled BDP in daily doses of 1,600 micrograms. Conclusion: These results suggested that suppression of the endogenous cortisol secretion occurs at inhaled budesonide and beclomethasone dipropionate is less suppressed on the adrenocortical function than budesonide in dose dependent fashion during the early periods,
이창섭(Chang Seop Lee),최수미(Soo Mi Choi),이흥범(Heung Bum Lee),이용철(Yong Chul Lee),이양근(Yang Keun Lee) 대한내과학회 1999 대한내과학회지 Vol.57 No.2
Scrub typhus is a acute febrile disease. Most patients were occurred from October to Nouember. The chief complaints were fever and chill, headache, cough, myalgia, pharyngitis and lymphadenopathy. Some patients with scrub typhus manifested with acute renal failure, meningoencephalitis, or hepatitis, but scrub typhus was rarely manifested with severe respiratory disease such as adult respiratory distress syndrome(ABDS). We report a case of scrub typhus manifested with ARDS. The patient was treated with doxycycline and recovered successfully.
만성폐쇄성폐질환에서 ACE 유전자 다형성과 기관지 과민성의 연관성
김승수 ( Seung Soo Kim ),최유진 ( Eu Gene Choi ),박성주 ( Seoung Ju Park ),이흥범 ( Heung Bum Lee ),이용철 ( Yong Chul Lee ),이양근 ( Yang Keun Rhee ) 대한결핵 및 호흡기학회 2005 Tuberculosis and Respiratory Diseases Vol.58 No.1
목적 : ACE 유전자 다형성에 따라 폐를 포함한 여러 조직에서 ACE 활성 및 농도 등에 차이를 나타내고 이러한 차이가 COPD 등의 만성 호흡기 질환에서 질환의 발생 및 임상 표현형의 차이를 유발할 것으로 추정되어지고 있다. 따라서 이 연구는 ACE 유전자 다형성이 COPD 환자에게서 동반될 수 있는 기도 과민반응 등의 기관지 천식 요소의 발현 유무와 연관성이 있는지 알아보고자 하였다. 방법 : 100명의 COPD 환자들을 대상으로 기도 과민성의 동 Background : An insertion-deletion polymorphism of angiotensin converting enzyme (ACE) gene has been shown to be associated with enzyme activity levels of ACE. Reported results that have been mutually contradictory about asthmatic hypersensitiveness and o