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이신영,김근호,Lee, Sin-Yeong,Kim, Geun-Ho 대한흉부심장혈관외과학회 1986 Journal of Chest Surgery (J Chest Surg) Vol.19 No.1
At the Department of Thoracic and Cardiovascular Surgery, Hanyang university, from 1976 to 1984, 102 patients operated for isolated patent ductus arteriosus were studied. The correlation between the degree of left ventricular hypertrophy [LVH] and hemodynamic data, and postoperative changes of electrocardiographic findings were evaluated. The following results were obtained; [1] Of 102 patients with isolated patent ductus arteriosus, 78 patients [76.5%] were found to have LVH by EKG, preoperatively. [2] The patients with LVH had higher incidence of respiratory infection [79.4%] compared to patients without LVH. [3] Frequent physical findings in the patients with LVH were precordial bulging and P2 accentuation on auscultation. The typical continuous machinery murmur was not different in two group with or without LVH. [4] 66.1% of patients with LVH showed more than 56% of cardiothoracic ratio [CTR] on simple chest X-ray. 56.5% of patients without LVH showed less than 50% of CTR. [5] In the patients found to have LVH by EKG, the correlation between values of Svl+Rv6 and Qp/Qs in hemodynamic data was correlation coefficient 0.57 and between CTR and Qp/Qs was correlation coefficient 0.51. [6] In patent ductus arteriosus with LVH following surgery, the values of Svl+Rv6 was changed from preoperative 153.6$\pm$42.78% to 107.7$\pm$19.58% within 3 months and to 80.4$\pm$12.22%, which is within normal range of Svl+Rv6 on EKC, after 6 months.
이신영,강정호,지행옥,Lee, Sin-Yeong,Gang, Jeong-Ho,Ji, Haeng-Ok 대한흉부심장혈관외과학회 1987 Journal of Chest Surgery (J Chest Surg) Vol.20 No.1
The incidence of syphilitic aortic aneurysm was decreased now a day. We experienced a case of huge syphilitic ascending aortic aneurysm from just above portion of aortic annulus to about 1 cm below innominate artery without aortic insufficiency. Surgical correction was done by replacement of ascending aorta with woven Dacron graft under cardiopulmonary bypass. Postoperative course was uneventful and discharged 15 days after surgery with good condition.
이신영,최준복,천병익,Lee, Shin-Young,Choi, Jun-Bok,Chun, Byong-Ik 한국식품과학회 1985 한국식품과학회지 Vol.17 No.3
쌀보리와 겉보리전분의 희석 및 농후호화용액에 대한 리올로지적 성질을 여러 점도계를 사용하여 연구하였다. 희석전분액(0.05${\sim}$0.3%)의 점도특성은 Huggins식에 따르는 고유점도 및 해수에 의하여 설명할 수 있었으며, 농후전분용액(1${\sim}$5%)의 리올로지적 거동은 농도의 증가에 따라 시간의존성과 의가소성의 성질이 현저히 강해지는 특징을 나타내었다. 지수법칙을 적용하여 구한 점조도지수 값은 지수함수식에 따르는 농도 및 은도의존성을 나타내었다. 한편 이들 결과는 리올로지적 성질이 품종차이에 따라 크게 달라지는 경향을 보였다. 쌀보리전분은 겉보리전분보다 더 큰 고유점도값을 나타내었으며, 틱소트로픽성질이 더 강한 것으로 나타난다. 아울러 점조도지수 값의 농도 및 온도의존성도 더 높은 경향이었다. 그러나 보리전분은 다른 전분에 비하여 비교적 낮은 농도의존성과 높은 온도의존성을 갖는 특징을 보였다. The rheological studies on dilute and concentrate solutions of naked and covered barley starches were carried out with various viscosimeters. The rheology of dilute solutions (0.05-0.3%) were characterized by intrinsic viscosity and related parameter according to Huggins equation. Also, the rheology of the solutions of higher concentrations (1-5%) were characterized by time dependent characteristics and pseudoplastic behaviors. The values of consistency index according to the power equation were exponen tially dependent upon concentration and temperature. The results showed that the rheological properties could differ greatly due to difference in varieties. The naked barley starch exhibited higher intrinsic viscosity, more thixotropic behavior and more dependence of consistency index on concentration and temperature than the covered barley starch.
대동맥폐동맥중격결손과 좌상공정맥을 합병한 VSD의 치험
이신영,지행옥,Lee, Sin-Yeong,Ji, Haeng-Ok 대한흉부심장혈관외과학회 1986 Journal of Chest Surgery (J Chest Surg) Vol.19 No.4
A case of ventricular septal defect associated with aorticopulmonary septal defect, left superior vena cava, and pulmonary hypertension in 6 years old boy is presented. Teflon patch closure of ventricular septal defect through transtricuspital procedure and division and suture closure of aorticopulmonary window performed under cardiopulmonary bypass with cardioplegia. The postoperative course was uneventful and discharged with good general condition.
이신영,손동섭,김창호,Lee, Sin-Yeong,Son, Dong-Seop,Kim, Chang-Ho 대한흉부심장혈관외과학회 1986 Journal of Chest Surgery (J Chest Surg) Vol.19 No.2
We have experienced two cases of ascending aorta aneurysm with aortic regurgitation in Marfan`s syndrome. There were abnormal findings in cardiovascular system associated with abnormalities of skeletal systems. They had total replacement of the ascending aorta and aortic valve with Bjork-Shiley`s aortic valve composite graft and reimplantation of coronary ostia on the graft. Their postoperative courses were uneventful and discharged with good clinical results for follow up.
The Relaxing Effect of α-Defensin 1 on the Adrenergic Responses of Rat Bladder
이신영,Don-Kyu Kim,Kyung Do Kim,명순철,Moo Yeol Lee 대한약리학회 2011 The Korean Journal of Physiology & Pharmacology Vol.15 No.3
Defensins, cysteine-rich cationic polypeptides released from neutrophils, are known to have powerful antimicrobial properties. In this study, we sacrificed 30 rats to investigate the effects of α-defensin 1 on detrusor muscle contractions in isolated rat bladder. From the experiments we found relaxing effects of α-defensin 1 on the contractions induced by phenylephrine (PE) but not by bethanechol (BCh) in the detrusor smooth muscles. To determine the mechanisms of the effects of α-defensin 1, the changes of effects on PE-induced contraction by α-defensin 1 pretreatment were observed after pretreatment of Rho kinase inhibitor (Y-27632), protein kinase C (PKC) inhibitor (Calphostin C), potent activator of PKC (PDBu; phorbol 12,13-dibutyrate), and NF-κB inhibitors (PDTC; pyrrolidinedithiocarbamate and sulfasalazine). The contractile responses of PE (10−9∼10−4 M) were significantly decreased in some concentrations of α-defensin 1 (5×10−9 and 5×10−8 M). When strips were pretreated with NF-κB inhibitors (PDTC and sulfasalazine; 10−7∼10−6 M), the relaxing responses by α-defensin 1 pretreatment were disappeared. The present study demonstrated that α-defensin 1 has relaxing effects on the contractions of rat detrusor muscles, through NF-κB pathway. Further studies in vivo are required to clarify whether α-defensin 1 might be clinically related with bladder dysfunction by inflammation process.
대동맥판 폐쇄부전이 동반된 심실중격결손에서 대동맥판성형술
이신영,김창호,Lee, Sin-Yeong,Kim, Chang-Ho 대한흉부심장혈관외과학회 1993 Journal of Chest Surgery (J Chest Surg) Vol.26 No.4
Aortic valve insufficiency with ventricular septal defect is usually treatment by plication of prolased cusps. We have performed the aortic valvuloplasty by the Trusler`s method in 14 patients of ventricular septal defect associated with aortic insufficiency. The reoperations were performed in the 4 cases[29%] due to recurrent aortic insufficiency after aotic valvuloplasty. Two patients underwent aoritc valvular replacements for the tears of repaired aortic cusps after primary aortic valvuloplasty for aortic insufficiency. The other two patients had aortic valvuloplasties again. Death occured in one case of aortic valvular replacements. The cause of death was low cardiac output syndrome soon after aortic valvular replacement for recurrent aortic insufficiency .
10 kg 이하의 활로4징증 환자에서 완전교정술에 관한 임상적 고찰
이신영,김창호,Lee, Sin-Yeong,Kim, Chang-Ho 대한흉부심장혈관외과학회 1991 Journal of Chest Surgery (J Chest Surg) Vol.24 No.6
The surgical management of symptomatic tetralogy of Fallot in infants is debatable. From November 1986 to August 1990, 21 infants under 10 kg of the body weight with tetralogy of Fallot underwent primary repair. Mean body weight was 8.6$\pm$1.40kg. All the patient were clubbing and there were cyanotic except for 1 patient. Transannular patch was laid down in 8 patients. Right ventricular outflow patch was used with Goretex but pericardial patch was utilized in 3 patients at the initial period of operation. Incidence of the complications following total correction of tetralogy of Fallot was more frequent in the patients placed with transannular patch compared to the patients with right ventricular outflow tract patch. Two deaths occurred in the 21 patients, Hospital mortality was 9.4%, but there were no operative deaths in the patients who transannular patch was laid down. Causes of deaths were low cardiac output.