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윤희성 ( Hee Seong Yoon ),이시협 ( Si Hyub Lee ),염승돈 ( Seung Dohn Yeom ),한지영 ( Jeeyoung Han ),신정현 ( Jeonghyun Shin ),최광성 ( Gwang Seong Choi ),변지원 ( Ji Won Byun ) 대한피부과학회 2018 대한피부과학회지 Vol.56 No.9
Congenital hemangioma (CH) is a fully formed benign vascular tumor at the time of birth and do not proliferate in postnatal life. CH must be differentiated from infantile hemangioma. CH has three subtypes that are recognized based on their natural history: Rapidly involuting congenital hemangioma (RICH), non-involuting congenital hemangioma (NICH), and partially involuting congenital hemangioma (PICH). It is important to distinguish RICH from NICH because RICH spontaneously regresses but NICH does not. Herein, we report two patients diagnosed with RICH and NICH, respectively. We presented the clinical features as well as ultrasonographic and histologic findings to distinguish congenital from infantile hemangioma. (Korean J Dermatol 2018;56(9):556∼560)
안드로겐성 탈모증 환자에서 폴리감마 글루탐산 하이드로겔 나노입자에 포집한 혼합복합발효추출물 도포제의 임상시험
이선복 ( Seon Bok Lee ),황혜원 ( Hye Won Hwang ),허지혜 ( Ji Hye Heo ),이시협 ( Si Hyub Lee ),신현태 ( Hyun-tae Shin ),변지원 ( Ji Won Byun ),신정현 ( Jeonghyun Shin ),최광성 ( Gwang Seong Choi ) 대한피부과학회 2021 대한피부과학회지 Vol.59 No.2
Background: Androgenetic alopecia (AGA) is the most common cause of hair loss in adults. Topical application of the fermented extract of medicinal plants promoted hair growth through stimulation of the telogen to anagen transition in a mouse model. However, controlled studies are necessary to evaluate the efficacy of the topical application of the fermented extract solution in humans. Objective: We aimed to assess the efficacy and safety of topical poly-gamma glutamic acid hydrogel nanoparticlebased fermented extract of a medicinal plant solution (PGA solution) in terms of the clinical improvements in patients with AGA. Methods: This 24-week, randomized, double-blinded, placebo-controlled, single-center clinical trial enrolled 50 patients with AGA (36 men and 14 women); the participants were treated with either PGA solution or placebo twice daily for 24 weeks. Efficacy was evaluated by a phototrichogram (total hair count per 1 cm<sup>2</sup>), patient’s subjective assessments, and investigator’s subjective assessments of clinical improvements in overall hair regrowth. Any adverse reactions were reported during the study. Results: At week 24, compared with baseline, the PGA solution group showed a significantly increased hair density compared to the placebo group (7.24±2.52/cm<sup>2</sup> vs. 1.53±1.39/cm<sup>2</sup>, p<0.0001). The average hair density after 24 weeks was 129.90±23.04/cm<sup>2</sup> and 115.32±20.35/cm<sup>2</sup> in the PGA solution group and the placebo group, respectively. There was no adverse reaction over the 24-week period. Conclusion: PGA solution may provide a safe and effective adjunctive treatment for patients with AGA. (Korean J Dermatol 2021;59(2):81∼87)