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1P-253 Reinforced Tissue Adhesiveness of Cyclodextrin Incorporated Gelatin Bioglues
이시민,( Thai Thanh Hoang Thi ),이윤기,박경민,박기동 한국공업화학회 2017 한국공업화학회 연구논문 초록집 Vol.2017 No.1
Bioglues are becoming promising materials in diverse clinical applications. However, to satisfy clinical requirements, the adhesiveness and biocompatibility have to be improved. In this study, Cyclodextrin (CD) incorporated gelatin-hydroxyphenyl (GH) hydrogels as a bioglue were developed to enhance the tissue adhesion property. The tissue adhesive strength of GH/CD hydrogels were significantly increased by incorporating CD into GH hydrogels via supramolecular forces. At GH 5 wt% and CD 5 wt%, the composite hydrogels exhibited maximum adhesive strength (36.5 kPa), which was nearly 3.3 and 8 times higher than that of GH hydrogels and fibrin glue as a control, respectively. Through in vitro cell study, we also confirmed that the GH/CD composite hydrogels have an excellent cytocompatibility. This shows an emerging potential as a promising tissue adhesive material.
Hyaluronic Acid Microgel for Sustained Delivery of Therapeutic Proteins
이시민,박기동,손주영 한국공업화학회 2019 한국공업화학회 연구논문 초록집 Vol.2019 No.1
Short half-life and fast clearance of protein drugs induce frequent administration for therapeutic efficiency, causing physiological burdens and bacterial infections. To achieve long term delivery of therapeutic proteins, a novel injectable protein loaded hyaluronic acid microgel (HA microgel) via thiol-ene click chemistry was developed. The crosslinking density (0.4~12.6 kPa) and gelation time (41~165 sec) of HA hydrogels could be controlled at various polymer concentration. The spherical shape and size (2.5~4 μm) of HA microgel were analyzed by DLS and FE-SEM. The extended release pattern of a model protein from HA microgels was evaluated; 62.3% for 1 month with burst release. Moreover, this carrier was cytocompatible against hDFBs by WST-1. From the obtained results, we can suggest a novel promising microgel as a long term sustained delivery carrier for a variety of protein drugs. <sup>**</sup> Acknowledgements: 2018M3A9B5021319, NRF-2018R1A2B2004529
스털링 기관용 재생기에 관한 기초 연구 (III) - 복합메쉬 철망을 축열재로 한 재생기의 전열 및 유동손실 특성 -
이시민,김태한,Lee S. M.,Kim T. H. 한국농업기계학회 2005 바이오시스템공학 Vol.30 No.4
The output of Stirling engine is influenced by the regenerator effectiveness. The regenerator effectiveness is influenced by heat transfer and flow friction loss of the regenerator matrix. In this paper, in order to provide a basic data for the design of regenerator matrix, characteristics of heat transfer and flow friction loss were investigated by a packed method of matrix in the oscillating flow as the same condition of operation in a Stirling engine. As matrices, several kinds of combined wire screen meshes were used. The results are summarized as follows; The packed meshes with high mesh no. in the side of heater part of regenerator showed effective than the packed meshes with low mesh no. in the side of cooler part of regenerator. The temperature difference and pressure drop of the regenerator were not made by the specific surface area of wire screen meshes but by the minimum free-flow area to the total frontal area. Among the No. 150 single screen meshes, 200-60 combined meshes, the 200-150-100 combined meshes showed the highest in effectiveness.