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원진형(Jin Hyoung Won),안성구(Sung Ku Ahn),김수찬(Soo Chan Kim),이승헌(Seung Hun Lee) 대한피부과학회 1992 대한피부과학회지 Vol.30 No.4
Neurocutaneous melanosis is a rare congenital syndrome characterized by the presence of large or multiple congenital pigmented nevi and a benign or maigrant pigment cell tumor of the leptomeninges. The s ndrome is thought to represent an erroi in the morphogenesis of the embryonal neuroectoderm. Even in the absence of melanorra, symptomatic neurocut.aneous melanosis has extremely poor prognosis. We report a case of neiirocutaneous melanosis in 38-year-old male. He was noted at birth to have a giant pigmented nevus on the bathing trunk area. He presneted with severe headache. Brain CT sca n was performed and 4 x 4cm sized well demarcated contrast enhanced mass was seeii in the right frontal lobe. Histopatho.ogically, the tumor was composed of malignant melanoma cells. Multiple skin biopsies werperformed on the giant pigmented nevus and small nevi. All of the specimens revealed patterns typical of cornpound nevi. Dermatologists following patients with large or multiple congenial pigmented nevi should be aware of this condition to aid in prompt diagnosis. (Kor J Dermatol 1992;30(4):558-563)
말초 신경아세포종 ( peripheral neuroblastoma )
허원(Won Hur),원진형(Jin Hyoung Won),안성구(Sung Ku Ahn),이원수(Won Soo Lee),이승헌(Seung Hun Lee),최수임(Soo Imm Choi) 대한피부과학회 1993 대한피부과학회지 Vol.31 No.2
A case of peripheral neuroblastoma of a 33-year-old male, which was located on the left buttock, is presented. Histologcally, this tumor demonstrated smaliound cell infiltrations which were arranged in a characteristic rosette pattern and the tumor cells were positively stained with neuron specific enolase. We review the clinical, histopathological ultrastructural and immunohisto chemical characteristics of this rare tumor, as well as the differential diagnosis with other small round cell tumors. (Kor J Dermatol 1993; 31 (2): 253-257)
원진형,허원,안성구,이승헌,이경주 ( Jin Hyoung Won,Won Hur,Sung Ku Ahn,Seung Hun Lee,Kyung Joo Lee ) 대한피부과학회 1991 대한피부과학회지 Vol.29 No.6
Rifampin-induced thrombocytopenia has been recognized as an immunological reaction associated with intermittent high-dose therapy, although rarely seen with daily low-dose regimens. Our patient was a 33-year-old male who was given rifampin 600㎎/day po for the treatment of pulmonary tuberculosis. His platelet count dropped to 16,000/㎟ after 20 doses of rifampin. Purpura were present over the whole body without the presence of other bleeding sites. Rifampin was discontinued. His platelet count returned to normal three days after discontinuation of therapy. With the increasing use of rifampin for the treatment of tuberculosis, clinicians should recognize the possibility of this drug causing such serious immunological reactions as thrombocytopenia, hemolytic anemia, acute renal failure, and shock with daily or intermittent therapy.
이승헌,이성낙,강진수,강원형 대한피부과학회 1981 大韓皮膚科學會誌 Vol.19 No.6
Median raphe cyst is not a cornmon disease and represents a defect in the embryologic development of male genitalia. It occurs most commonly near the glans penis, but may occur anywhere from the urethral meatus to the anus, and is lined by entodermal or ectodermal epithelium. Surgical excision is the treatment of choice. Recently we observed a 29-year-old male patient who had had a typical median raphe cyst since childhood on the ventral aspect of the glans penis. On histological examination, the cyst was lined by stratified columnar epithelium varied from four to eight cells in thickness.