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8년 동안 진행된 만성치열(Chronic anal fissure) 환자에게 치자시탕과 상담요법을 사용하여 호전된 치험 1례
이숭인,조민석,이성준,정종길,Lee, Soong-in,Cho, Min-seok,Lee, Sung-jun,Jeong, Jong-kil 대한한의학방제학회 2015 大韓韓醫學方劑學會誌 Vol.23 No.1
Objectives : This study is aimed to report the outcomes of the treatment of a patient with chronic anal fissure during a 8-year period. Methods : Basic patient’s data was analyzed as a CARE guideline. And related psychological state was measured with BAI, STAI-X-II test. Results : The treatment is based on Shanghanlun and the patient reported better outcomes. The main symptoms of the patient were chronic constipation, blood in the stool. The main clinical findings were that the patient’s symptoms got worse during the examination period because of the anxiety of the exam. And loss of appetite and digestive disorders are due to Jue-Yin-Bing(厥陰病) and the clue of bleeding can be found in article 375 in Shanghanlun. The main diagnoses was chronic anal fissure and main interventions were Chijasi-tang according to article 375 in Shanghanlun and counseling on anxiety. As a results bleeding has stopped after taking herbal medicine and constipation has been treated at the same time. After 6 months, the patient performed BAI, STAI-X-II test and scores got lowered indicating decreasing anxiety level. Conclusion : Chijasi-tang with counseling achieved valid positive results to the patient with chronic anal fissure.
비자 열수 추출물의 항산화 활성 및 뇌신경세포 보호효과 연구
이숭인,최찬헌,김정상,임성수,정현우,Lee, Soong-In,Choi, Chan-Hun,Kim, Jeong-Sang,Lim, Seong-Soo,Jung, Hyun-Woo 대한본초학회 2017 大韓本草學會誌 Vol.32 No.6
Objectives : This study was designed to estimate the antioxidative and neuroprotective effects of Torreyae Semen hot water extracts (TS). Methods : Torreyae Semen was extracted by hot water for 2 hours with a temperature of 105 degrees. Polyphenols and total flavonoid were measured and LC-MS/MS was used to certificate anticipated antioxidative compounds. The antioxidant activities of TS were measured as scavenging effects of 1,1-Diphenyl-2-picrylhydrazyl (DPPH) and Nitrite Oxides (NO). Cell viability and proliferation rate was measured MTT assay. The toxicities to thymocytes and splenocytes were evaluated by the proliferation rate of primary cultured cells of 7 weeks, male Balb/c mice. The antioxidant activities of TS on C6 mouse glioma cells were measured by the analysis of total glutathione contents variation. The neuroprotective effects against oxidative stresses were measured by MTT assay. Results : Polyphenols of TS was $92.00{\pm}1.24{\mu}g/mg$, and total flavonoids was $0.36{\pm}0.14{\mu}g/mg$. TS includes gallocatechin, epigallocatechin, gallocatechin gallate and epigallocatechin gallate. TS included gallocatechin, epigallocatechin, gallocatechin gallate, epigallocatechin gallate. TS showed DPPH and NO scavenging effects as dose-dependent manner at the concentrations of $0-10mg/m{\ell}$. In MTT assay, TS shows no significant toxicity to C6 cells, primary cultured thymocytes and splenocytes of Balb/c mice. TS increased the level of total glutathiones. TS increased cell viabilities of C6 cells against oxidative stresses such as $H_2O_2$, sodium nitroprusside (SNP), Rotenone at the concentrations of $0-0.063mg/m{\ell}$. Conclusions : TS shows the antioxidant and neuroprotecitive effects in these experiments.
『상한론(傷寒論)』 변병진단체계(辨病診斷體系)에 근거하여 소음병(少陰病) 오수유탕(吳茱萸湯)을 투여한 후 호전된 구진성·결절성 여드름 증례 1례
최재영 ( Jae-young Choi ),이숭인 ( Soong-in Lee ),이성준 ( Sung-jun Lee ) 대한상한금궤의학회 2020 대한상한금궤의학회지 Vol.12 No.1
Objective: In this study, we aimed to inform people that acne can be improved with Osuyu-tang (OSYT) based on the Shanghanlun disease pattern identification diagnostic system (DPIDS). Methods: We evaluated the progress of symptoms, patient compliance, and presence of side effects after the patient took OSYT. The progress of acne treatment was evaluated using the Korean Acne Grading System (KAGS), visual findings, and patient statements. Results: According to the DPIDS, the patient was diagnosed with provision 309 of soyinbing. After administration of OSYTfor 50 days, KAGS decreased from grade 3 to grade 1. Cold hands and feet improved significantly. Conclusions: Through this case study, we showed the possibility of the clinical interpretation and application of OSYT and suggested further case studies in the future.
상한론에 근거하여 소화기 이상을 동반한 지루성 피부염 환자에 대한 적석지우여량탕 치험 1례
이성준,윤혜지,이숭인,Lee, Sung-Jun,Yoon, Hye-ji,Lee, Soong-In 대한한의학방제학회 2016 大韓韓醫學方劑學會誌 Vol.24 No.1
objective The purpose of this case report is to review the possibility of utilizing Jeokseokji-uyeoryang-tang as a therapy of seborrheic dermatitis, and to consider clinical using possibility of Shanghanlun.method Patient's Diagnosis and progress of seborrheic dermatitis was evaluated based on the patient's chart and picture. And diagnosis based on Shanghanlun was organized by table.results When analyzing the patient's history and symptoms, it can be found in article No. 159 in Shanghanlun. The area and intentsiy of erythema were reduced when viewed photos findings, so diagnosis and therapies used in this case showed valid results in seborrheic dermatitis.conclusion Jeokseokji-uyeoryang-tang is efficient to patient of this case report as a treatment.
상한론에 근거하여 오수유탕을 이용하여 호전된 건선 치험 1례
이성준,서희애,이숭인,Lee, Sung-Jun,Seo, Hee-ae,Lee, Soong-In 대한한의학방제학회 2016 大韓韓醫學方劑學會誌 Vol.24 No.1
Objective The object of this case report is to evaluate the possibility of utilizing Osuyu-tang as a new therapy of psoriasis.Method Diagnosis and Psoriasis' progress was evaluated based on the patient's chart and picture. Diagnosis based on Sanghanlun was organized by graph. The severity of psoriasis' progress was evaluated by Psoriasis Area Severity Index(PASI) and visually analyzed through picture.Results On PASI and picture, we could confirm psoriasis’s area was decreased from hairline to middle of forehead and redness, thickness, scale of psoriasis also got better.Conclusion Osuyu-tang is efficient to patient of this case report as a treatment.
천마가미방이 Scopolamine으로 유발된 흰쥐의 해마 손상에 미치는 영향
박은혜 ( Eun Hye Park ),이숭인 ( Soong In Lee ),정종길 ( Jong Kil Jeong ),김경옥 ( Kyeong Ok Kim ),김정상 ( Jeong Sang Kim ) 대한본초학회 2015 大韓本草學會誌 Vol.30 No.3
Objectives : This study investigated the neuroprotective effect of Gastodia Rhizoma-gamibang (GG) water extracts against scopolamine-induced neurotoxicity in the hippocampus of male Sprague-Dawley rats. Methods : The animals were divided into five different groups with six animals per each group. The normal group (Nor) was administered with saline, while the control group (Con) was administered with saline after scopolamine treatment. The experimental group (Exp) was administered orally GG extracts at doses of 200 ㎎/㎏ (GG1 group), 400 ㎎/㎏ (GG2 group), 1000 ㎎/㎏ (GG5 group) for 30 day after scopolamine treatment. Results : From a light microscopy study, the nuclei of neurons and glial cells in the hippocampus were more shrunken or condensed in the 30 day control group compared with normal group. In the experimental groups, proportional to the dose, recovered from neurotoxicity induced by scopolamine. The control group, the density of hippocampal neurons were reduced 17-20% compared to normal group. The densities of neurons from the CA1, and CA3 area of the hippocampus in the GG1, GG2 and GG5 groups significantly increased compared with the Con. In the experimental group, neuronal cells are recovered from scopolamine-induced damage. A number of glial cells are observed increase from GG2 and GG5 groups. The PAS-positive materials in the tissues hippocampus), was lower in the Exp than the Con. Conclusions : The present study demonstrates that Gastodia Rhizoma-gamibang extract reduces neuronal damage in the hippocampus of scopolamin-induced impairment mice.
대승기탕의 사하작용(瀉下作用)에 대한 약리학적 연구 분석
변성희,허신철,배정혜,조강문,이숭인,Byeon, Sung-Hee,Hur, Shin-Chul,Bye, Jeong-Hye,Jo, Gang-Mun,Lee, Soong-In 대한한의학방제학회 2018 大韓韓醫學方劑學會誌 Vol.26 No.1
Objective : This study's purpose was to review the Daeseunggi-tang as the typical purgative. Method : We searched papers about Daeseunggi-tang about the gastrointestinal dysfunction caused by constipation, surgery and MODS. In total, 31 papers were analyzed in this study. Results : In matter of subject, researches on the gastrointestinal dysfunction caused by constipation were 16 cases, researches on the gastrointestinal dysfunction caused by surgery were 8 cases, researches on gastrointestinal dysfunction caused by MODS were 7 cases. Conclusion : In conclusion, the traditional use of Daeseunggi-tang on constipation, frequent flatus, and stomachache has proven to have sufficient evidences through the experimental and clinical evidences.
추한나 ( Han-na Choo ),이숭인 ( Soong-in Lee ),김정상 ( Jeong-sang Kim ),정종길 ( Jong-kil Jeong ) 대한본초학회 2015 大韓本草學會誌 Vol.30 No.4
Objectives: Clerodendron trichotomum Thunberg grows wild fields and mountains in South Korea and China. They have been used for anti-hypertension disease. This study was performed in order to observe the effects of Clerodendron trichotomum Thunberg tea on anti-hypertension. Methods: For the study of Clerodendron trichotomum Thunberg tea, we had divided male SHR (Spontaneously Hypertensive Rat) to ten groups. Control group is SHR. The treatment group is SHR which is administered tea extract at dose of 200 mg/kg/day and 500 mg/kg/day orally for 8 weeks. We measured systolic blood pressure, diastolic blood pressure, number of pulse, body weight, total cholesterol and triglyceride from blood serum. Results: The level of systolic and diastolic blood pressure were significantly decreased by 12.5% and 44.9% in Clerodendron trichotomum Thunberg tea groups than control group. Heart rate of Clerodendron trichotomum Thunberg tea groups, 24.5%, was significantly lower than control group. We found that treatment with the water extract from Clerodendron trichotomum Thunberg leave and flower significantly decreased weight of body, total cholesterol and triglyceride to 20.4% and 27.7% compared to untreated control group, significantly ( P< 0.05). Conclusions: These results suggest that leaf and flower tea of Clerodendron trichotomum Thunberg tea is effective in prevention and treatment of hypertension and decreasing cholesterol. Long term consumption of Clerodendron trichotomum Thunberg leaf and flower tea can be help in lowering high systolic and blood diastolic pressure, heart rate and blood serum in SHR.
『상한론(傷寒論)』 변병진단체계(辨病診斷體系)에 근거하여 대황황련사심탕(大黃黃連瀉心湯) 투여 후 혈압이 안정된 고혈압 증례 보고
최재영 ( Choi Jae-young ),이숭인 ( Lee Soong-in ),이성준 ( Lee Sung-jun ) 대한상한금궤의학회 2018 대한상한금궤의학회지 Vol.10 No.1
Objective : The purpose of this study is to review a case of hypertension. The patient was 41 years, a male. We stabilized blood pressure after administration of Daehuanghuanglianxiexin-tang. In this paper, we review the interpretation of Shanghanlun by analyzing the patient’s progress, diagnosis, treatment. Methods : Blood pressure changes have been monitored during the period. Additionally, We have observed the patients’ compliance and accompanied symptom by the timeline analysis. Results : According to Shanghanlun disease pattern identification diagnostic system, Wediagnosed a Greater yang disease. The patient was treated with Daehuanghuanglianxiexin-tang for 2 months. Daehuanghuanglianxiexin-tang was able to control blood pressure to under 120mmhg / 80mmhg. During the treatment period, the accompanied symptom Stiffness and pain in posterior neck has improved, patient’s compliance was good, and symptoms improved without significant complication Conclusions : Taking of the Daehuanghuanglianxiexin-tang makes patient’s blood pressure controlled to safe and stable range and eases the discomfort of posterior neck pain
『강평상한론(康平傷寒論)』 15자행(字行) ‘결흉(結胸)’의 진단적 의미 고찰
하현이 ( Ha Hyun-yee ),이성준 ( Lee Sung-jun ),이숭인 ( Lee Soong-in ) 대한상한금궤의학회 2018 대한상한금궤의학회지 Vol.10 No.1
Objectives : Purpose of this study is to suggest a diagnostic definition of Chest bind(結胸) in GangpyeongShnghanlun 15 letters provision. Methods : Using The Etymology Dictionary of Chinese Characters, we interpreted the meaning of Chest bind(結胸) and symptoms on 134th provision of Shanghanlun. Results : The meaning of Chest bind is endurance of worries. Symptoms on 134th provision can be interpreted as follows. Worrywart person whose behavior is dilatory, who suffer from an inferiority complex, feel pressure on chest, feel heavy with worries, unstable, talkative, suffer from a feeling of anger, think himself as fallen into a trap, feel always nervous and is stubborn can be in a situation of Chest bind. Conclusions : Chest bind is one of the Names of disease in Shanghanlun. The Name of disease has its own meaning that can be used as diagnostic evidence. Further studies are needed to verify a hypothesis of diagnostic definition of Chest bind.