http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
서비스디자인 관점에서 본 이해관계자의 취업지원이 비자발적 퇴직자의 구직활동에 미치는 영향
이숙경(Lee Suk Kyoung),구유리(Yoori Koo) 한국HCI학회 2018 한국HCI학회 학술대회 Vol.2018 No.1
비자발적 퇴직자의 중장년층 재취업을 위해서는 이해관계자(고용센터담당자, 전직지원컨설턴트, 직업상담사, 훈련교사, 인사담당자, 인적네트워크 등)의 취업지원이 구체적 구직활동에 긍정적 영향을 미치고 있다는 것에 그 중요성이 있고, 비자발적 퇴직자의 취업 성공 여정을 정리 함으로써 재취업에 어려움을 겪고 있는 비자발적 퇴직자의 성공취업에 기여하고자 한다.
조병식 ( Byoung Sik Cho ),곽승기 ( Seung Ki Kwok ),서영일 ( Young Il Seo ),민도준 ( Do June Min ),김완욱 ( Wan Uk Kim ),이숙경 ( Suk Kyoung Lee ),박성환 ( Sung Hwan Park ),조철수 ( Chul Soo Cho ),김호연 ( Ho Youn Kim ) 대한류마티스학회 2001 대한류마티스학회지 Vol.8 No.4
Rheumatoid arthritis(RA) is occasionally associated with variable extra-articular involvement and the chronic inflammatory process can affect the gastrointestinal system. The gastrointestinal involvement in RA may present in many causes: drug induced colitis, vasculitis and amyloidosis involved in the gut, association with certain bowel diseases such as collagenous colitis or infectious colitis. Ulcerative colitis(UC) is a chronic inflammatory bowel disease and is commonly associated with peripheral joint disease which correlates with the disease activity and extent of the bowel inflammation. The arthritis is usually presented in pauciarticular, generally asymmetric, transient, and nondestructive pattern. However, the chronic and destructive peripheral arthritis has been reported in a few cases and RA has not been observed in association with UC. We experienced a case of RA patient with recurrent abdominal pain, hematochezia, and tenesmus who was diagnosed as UC by endoscopic and histologic finding. We herein report the case with literature.
HSV-TK 유전자를 암호화하는 EBV 유래 플라스미드를 이용한 유전자 치료
오상택,민경아,김종국,이숙경 한국약제학회 2003 Journal of Pharmaceutical Investigation Vol.33 No.4
Herpes simplex virus (HSV) thymidine kinase (TK) has been widely used for suicidal gene therapy in combination with nucleoside analogs such as ganciclovir (GCV). The use of HSV-TK is limited due to the side effect of GCV at high concentraions. Previous studies showed that stable transfectants of mustant HSV-TK with enhanced affinity to GCV were killed at lower GCV concentrations. In this study, we tested whether mutant HSV-TK can provide enhanced suicidal effect when trasiently transfected with Epstein-Barr virus (EBV)-based plasmid. EBV-based plasmid which contains Orip and EBNA-1 sequence is well known for a stable espisomal maintenance in human cells. Optimal transfection condition was assessed for SNU-638 gastric cancer cell line using polyethylenimine (PEI). Maximum transfection efficiency was achieved when DNA:PEI was 1:3 (w/v). Cytotoxicities of mutant and wild type HSV-TK were compared before and after partially selecting transfected cells. The were sensitive to 100?/ml hygromycin. Following GCV treatment, more cells were killed after hygromycin selection than before selection. The mutant HSV-TK showed enhanced cytotoxicity compared with the wild type HSV-TK. Our results suggest that the EBV-based plasmid encoding mutant HSV-TK may be useful to treat the diseases caused by uncontrolled cell proliferation such as cancer and rheumatoid arthritis.