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백내장 마우스의 유전적 연쇄지역 D14Mit86의 physical map과 candidate 유전자 탐색
김은민(Eunmin Kim),이상달(Sang Dal Rhee),이형남(Hyoungnam Lee),양승돈(Sung-Don Yang),Masaaki Okumoto,송창우(Chang-Woo Song),김성주(Sung-joo Kim) 한국실험동물학회 2004 한국실험동물학회 학술발표대회 논문집 Vol.2004 No.-
백내장 모델 동물인 CXSD 마우스는 백내장이 상염색체 열성으로 유전되는 모델 마우스로써, 5 주령부터 백내장의 첫 증상이 나타나기 시작하며 10 주령까지 모든 마우스에서 백내장이 유발되는 완전 침투도를 나타낸다. CXSD 마우스의 원인 유전자인 lens rupture 2 (Ir2)를 positional cloning를 통하여 탐색하고자 D14Mit86 부위의 마우스 genomic DNA를 insen로 가지고 있는 BAC 클론들과 YAC 클론들의 Sequence Tagged Site (STS) content를 결정하여 physical map을 작성하였다. 유전자 표식자인 D14Mit86 지역을 기준으로 physical map을 작성한 결과 40중의 BAC 결론과 4종의 YAC 클론으로 29종의 STS의 순서를 결정하였으며, 이 STS map은 5종의 유전자 표식자, 18종의 clone-end markers, 6종의 gene specific EST markers로 구성되어 있다. 본 논문의 physical map에 mapping 된 유전자는 총 6종으로써, Adam 7, Decysin, Adam28, Sic, Nkx3-1과 LAP70이며, 마우스와 인간 사이에 존재하는 homology에 의해 탐색된 유전자들이다. 이 유전자들 중 Adam 7, Decysin, Adam28은 그 위치에 의거하여 Ir2 환인 유전자로서의 가능성이 있다. A recessive cataractous mouse, CXSD, showed the first clinical symptom of cataract at 5 weeks old and the penetrance was complete. Toward the identification of lens rupture 2 (Ir2)gene causing cataract by positional cloning, we constructed an sequence tagged site (STS)-content map of the region around D14Mit86 that was shown to be linked to Ir2 genetically. We determined the physical order of 29 STSs that were dispersed among 4 YAC clones and 40 BAC clones. The markers included 5 genetic, 18 clone-end, 6 gene specific EST markers. The genes include Adam 7, Decysin, Adam28, Sic, Nkx3-1 and LAP70 and Nkx3-1 was known to map to the human chromosome 8p21. Therefore, this map represents the part of mouse genome synteny to that of the human genome. The current map would provide groundwork for identification of Ir2 gene.
고지방식이 수컷 micro-pig에서 경신강지환(經身降脂丸) (GGEx)의 고지혈증 개선효과
양유인,정양삼,이희영,이상달,김병출,김종훈,석화준,유재상,윤기현,조주흠,김훈,김경철,신순식,Yang, Yoo-In,Jung, Yang-Sam,Lee, Hee-Young,Rhee, Sang-Dal,Kim, Byoung-Chul,Kim, Jong-Hoon,Seok, Hoa-Jun,Yoo, Jae-Sang,Yoon, Ki-Hyeon,Jo, Ju-Heum,Kim, 대한한의학방제학회 2006 大韓韓醫學方劑學會誌 Vol.14 No.2
Objectives : We evaluated anti-hyperlipidemia effect of Gyeongshinganjeehwan (GGEx) in high fat induced obese male micro-pigs. Methods : 7 month-old micro-pigs are fed with normal (n = 3) or high fat diet (n = 18) for 12 weeks. The pig revealed obesity in high fat diet were divided into 2 groups (n = 5 each) and vehicle (OMP) and Gyeongshingangjeehwan (GGEx, 616.7 mg/kg/day) were administrated for 1 month. We monitored the changes in body weight and measured plasma cholesterol, triglyceride, free fatty acid, GOT and, GPT after 1 month. The visceral fat were measured with computerized tomography and weights of various organs were measured after sacrifice. Results : 1. GGEx group had significantly reduced body weight gain than obese control group in statistics. 2. GGEx group didn't significantly differ from obese control group in blood total cholesterol, blood LDL-cholesterol, blood triglyceride. but it's data were similar to normal control group. 3. GGEx group had prominantly reduced visceral fat than obese control group in computerized tomography. 4. Blood GOT and GPT didn't differ from between groups. The organ weight were not significant different. And it is normal in size and colour of visceral organs. Conclusions : It is concluded that GGEx has anti-hyperlipidemia effect by improving visceral fat and access to security.