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이병무,Lee, Byung-Mu 한국독성학회 1992 Toxicological Research Vol.8 No.2
Fifty chemicals are currently classified as human carcinogens based on epidemiologic and animal data. Humans are daily exposed to them from various sources of exposure via inhalation, dermal contact and oral ingestion. To reduce cancer risk to man, these human carcinogens should be appropriately regulated and monitored environmentally or biologically for routine human cancer risk assessment. A number of mathematical risk assessment models have been introduced, but any realistic and relevant model system is not available for humans. A mechanistic process for human cancer risk assessment was comprehensively reviewed and problems were also discussed. Here, a new conceptual approach using epidemiology and biological human monitoring was suggested for the most relevant method to study human cancer risk assessment.
이병무(Byung Mu Lee),최설민(Seul Min Choi),조현(Hyun Cho),안병옥(Byoung Ok Ahn),김원배(Won Bae Kim) 한국독성학회 2001 Toxicological Research Vol.17 No.2
The anti-emetic effect of a 5-HT₃receptor antagonist, Ondaron, was compared with that of the approved ondansetron agent, Zofran® in the ferrets. Emesis was induced by single intraperitoneal injection of cisplatin 10 mg/kg, and Ondaron or Zofran® was injected intraperitoneally in a dose of 1.0 mg/ kg, respectively. Ondaron and Zofran® effectively antagonised the emetic response for 4 hours after injection. They significantly reduced the number of vomiting and retching, and prolonged the latency to the first episode. The anti-emetic effect of Ondaron was almost the equal to that of Zofran®. These results suggest that Ondaron is an effective anti-emetic agent against cisplatin-induced emesis, and its anti-emetic potency is similar to that of 5-HT₃receptor abtagonist, ZoJran®.
Genotoxicity and Skin Penetration of Silver Nanoparticles in Hairless Mice After Dermal Exposure
이병무 ( Byung Mu Lee ),( Dong Eun Jang ),( Eun Hwa Kwak ),( Seung Jun Kwack ),( Jea Yeon Jung ),( Mi Jung Kwon ),( Eun Young Han ),( Il Young Ahn ),( Jung Yun Bae ),( Seong Kwang Lim ),( Dong Hyun Kim ) 한국피부장벽학회 2010 한국피부장벽학회지 Vol.12 No.1
Silver nanoparticles have been used for a variety of consumer products which may directly contact the skin. This study aims to investigate genotoxicity in vitro and skin penetration of silver (Ag) nanoparticles of varying sizes in male SKH1-hairless mice. Dorsal skin of six-week-old hairless mice was treated with 5-10, 100, and 160 nm silver nanoparticles at 1, 10, and 100 mg/kg body weight for 1 month. After dermal exposure of size-dependent silver nanoparticles for 4weeks, blood, urine and organ distribution of silver nanoparticles was measured by ICP-MS (inductively coupled plasma mass spectrometry) analysis. In case of 5-10nm silver nanoparticle treatment, silver concentrations were increased in a dosedependent manner at all measured organs and body fluid. Silver nanoparticles were absorbed through the skin and distributed in the body. The concentrations of silver nanoparticles were highest in the liver among various organs measured and followed by kidney, heart, and brain (liver>kidney>heart> urine>brain>blood in order). In 100 nm and 160 nm silver nanoparticles treatment groups, silver concentrations in the organs and body fluids were also increased in a dose-dependent manner. Blood biochemistry showed that GOT (glutamic oxaloacetic transaminase), ALP (alkaline phosphatase), TG (triglyceride), and BUN (blood urea nitrogen) values were significantly increased in the sera from high-dose group (5-10nm). Mutagenicity tests showed that Ag nanoparticles alone are not genotoxic, but genotoxic in combination of Fe++ or Cu++. These results suggest that silver nanoparticles, dependent on particle size and concenration, are able to be absorbed through the skin and may produce hepatotoxicity in vivo and genotoxicity in the presence of metal ions such as Fe++ or Cu++
LD<sub>50</sub> 산출방법에 있어서 수리 · 통계학적 특성
김세기,김근종,이병무,Kim Se Ki,Kim Keun-Chong,Lee Byung Mu 한국독성학회 2004 Toxicological Research Vol.20 No.4
Lethal dose 50% ($LD_{50}$) has been commonly used as a parameter for the estimation of acute toxicity not only in animal experiment, but also in human study. Several methods to estimate $LD_{50}$ had been introduced, but Spearman-Karber and Berens-Karber method have been widely used due to their relative convenience and accuracy. However, $LD_{50}$ values estimated from the two methods showed inconsistency and variation depending on the characteristics of mortality data. In this study, the two methods were comparatively investigated in terms of accuracy and stability for the estimation of $LD_{50}$.
Quinone계 화합물의 발암성 조기검색법에 관한 연구
조대현,홍진태,박정식,홍연탁,진강,정명희,이병무,Cho, Dae-Hyun,Hong, Jin-Tae,Park, Jeong-Sik,Hong, Youn-Tack,Chin, Kang,Jung, Myung-Hee,Lee, Byung-Mu 한국독성학회 1992 Toxicological Research Vol.8 No.2
To investigate a short term screening method for carcinogenic quinone compounds, 8-hydroxydeoxyguanosine (8-OHdG), an oxidative DNA damage, was determined in the kidney and liver DNA isolated from Sprague-Dawley rats after i.p.injection of 7 mg/kg adriamycin (AM), 7mg/kg tetrahydropyranyladriamycin (THP), and 10mg/kg daunomycin (DM) by HPLC-electrochemical detector system. 8-OHdG was also determined from rat hepatocvtes and calf thymus DNA exposed to AM, DM and THP. When rats were treated with DM and THP, 8-OHdG was significantly increased in the kidney compared to control group, and remained at high level (7.9~9.0, 8-OHdG/dG${\times}10^4$)at the end of experiments (48hr after treatment). 8-OHdG level in cultured hepatocyte exposed to AM, DM and THP was 1.5~2 fold higher than control at all time points. (1,2,3,4hr after treatment). From calf thymus DNA exposed to AM, DM and THP, 8-OHdG was 2.5 fold higher than of control. These results suggest that quantitation of 8-OHdG may provide a useful marker for identifying target organ in oxidative chemical carcinogenesis and for short term screening of free radical generating carcinogens.
프로스타글란딘 유도체의 합성과 그의 생물학적 활성에 관한 연구 2. 위궤양과 위산분비에 대한 프로스타글란딘 유도체의 효과
조태순(Tai Soon Cho),이선미(Sun Mee Lee),함원훈(Won Hun Ham),이병무(Byung Mu Lee),김경례(Kyoung Rae Kim),지상철(Sang Cheol Chi),고준일(Jun Ill Ko),박인(In Park),오창영(Chang Young Oh),박호군(Ho Koon Park),김형자(Hyoung Ja Kim),이향우(H 한국응용약물학회 1995 Biomolecules & Therapeutics(구 응용약물학회지) Vol.3 No.1
The antiulcer effects of newly synthesized prostaglandin derivatives were investigated in various experimental ulcer models and on gastric secretion in rats. HK-3 and HK-4, PGE₂ derivatives, prevented the formation of acute gastric ulcer induced by ethanol or aspirin in pylorus-ligated rats. The ulcer formation was moderately inhibited by HK-1 and HK-2, PGF_(2α) derivatives, and aggravated by SK-1, SK-2 and SK-3, PGF_(2α) derivatives. HK-3 and HK-4 reduced the volume, acid output and pepsin output of gastric juice in pylorus-ligated rats. The gastric perfusion with physiologic saline(pH 6.0) showed relatively constant acid secretion and indomethacin increased the acid secretion. The acid secretion was markedly decreased by PGE₂ but PGF_(2α) caused little change. Prostaglandin derivatives, especially HK-3 and HK-4, significantly inhibited the acid secretion induced by indomethacin. The results show that, PGE₂ derivatives, HK-3 and HK-4, inhibit acid secretion and also have protective effects on gastric ulceration induced by ethanol or aspirin.