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염산 피오글리타존과 HPMC의 고체분산체에 의한 용출율 조절
김원 ( Won Kim ),이은용 ( Eun Yong Lee ),김대성 ( Dae Sung Kim ),정수현 ( Su Hyun Jung ),안식일 ( Sik Il Ahn ),박종학 ( Jong Hak Park ),오재민 ( Jae Min Oh ),김윤태 ( Yun Tae Kim ),이영현,이동원 ( Dong Won Lee ),이종문 ( John M Rhee 한국조직공학·재생의학회 2009 조직공학과 재생의학 Vol.6 No.4
This study was carried out to find the formation of solid dispersion for overcoming initial burst of pioglitazone HCl. We prepared pioglitazone HCl solid dispersion as contents of polymeric material as hydroxypropyl methylcellulose(HPMC). HPMC is the most important hydrophilic carrier used for the preparation of oral controlled drug delivery systems. One of its most important characteristics is the high swellability, which has a significant effect on the release kinetics of an incorporated drug. We analyzed surface of solid dispersed sample by scanning electron microscope(SEM) and X-ray diffraction(XRD) was used to analyze the crystallinity. Also the change of structure and crystallinity characteristic of solid dispersion tablet were analyzed by fourier-transform infrared spectoscopy(FT-IR). We prepared tablet with solid dispersion by direct compression and observed in vitro release behavior of solid dispersion from tablets in gastric juice(pH 1.2). The result was compared with release behavior of commercial drug(Actos(R)) and solid disperesd pioglitazone HCl.
염산 트라마돌을 함유하는 PLGA 미립구의 제조 및 방출거동
박종학 ( Jong Hak Park ),엄신 ( Shin Eom ),안식일 ( Sik Il Ahn ),김대성 ( Dae Sung Kim ),김원 ( Won Kim ),이동원 ( Dong Won Lee ),유일수 ( Il Sou Yoo ),이종문 ( John M Rhee ),강길선 ( Gil Son Khang ) 한국조직공학·재생의학회 2009 조직공학과 재생의학 Vol.6 No.4
Tramadol HCl(TH)-loaded poly(L-lactide-co-glycolide)(PLGA) microspheres were prepared by O/O solvent evaporation method for sustained release. We investigated the release behavior according to PLGA molecular weight and concentration. TH-loaded PLGA microspheres were characterized on the surface and cross-section morphology by SEM. TH-loaded PLGA microspheres had smooth surfaces and various pores in internal structure. As the PLGA molecular weight and PLGA concentration increased, the release rate of TH decreased. The behaviors of degradation was decreased according to increased PLGA molecular weight. These results showed that the release behaviors can be controlled by various of molecular weight and concentration of PLGA.
PVP의 분자량에 따른 시부트라민 고체분산체의 방출거동에 대한 영향
이준희 ( Jun Hee Lee ),양재찬 ( Jae Chan Yang ),이영현 ( Young Hyun Lee ),김대성 ( Dae Sung Kim ),김원 ( Won Kim ),박종학 ( Jong Hak Park ),안식일 ( Sik Il Ahn ),김윤태 ( Yun Tae Kim ),이동원 ( Dong Won Lee ),이종문 ( John M Rhee 한국조직공학·재생의학회 2009 조직공학과 재생의학 Vol.6 No.1
The aim of this study was designed to evaluate properties and dissolution rates of sibutramine solid dispersions by spray drying. Sibutramine as appetite depressant for obesity treatment is soluble in low pH but insoluble in high pH. To improve bioavailability, it should be improve dissolution rate in pH 6.8 because sibutramine is absorbed at the small intestinal track. PVP has various molecular weights according to K values. We investigated effect of molecular weights of PVP on the release behavior of solid dispersion. DSC and XRD were used to analyze the crystallinity of the sample. It was found that sibutramine is amorphous in the solid dispersions. FT-IR was used to analyze the salt formation by hydrogen bond between sibutramine and PVP. As a result of in vitro release behavior, solid dispersion using PVP K30 is obtained good possibility of orally pharmaceutical formulation. This study proposed that this solid dispersion system controlled the release behavior according to molecular weights.
안식일 ( Sik Il Ahn ),엄신 ( Shin Eom ),김용기 ( Yong Ki Kim ),김대성 ( Dae Sung Kim ),김원 ( Won Kim ),전나리 ( Na Ri Jeon ),이동원 ( Dong Won Lee ),이종문 ( John M Rhee ),강길선 ( Gil Son Khang ) 한국조직공학·재생의학회 2009 조직공학과 재생의학 Vol.6 No.4
There are two methods to treating onychomycosis. They are oral therapy and topical therapy. In this study we investigated the topical therapy. Penetration enhancer is necessary for effective topical dose of nail. KOH, NaOH and NaBH4 that have a potentiality as a penetration enhancer were dissolved in distilled water at 3% w/v concentration. And then nails are treated with penetration enhancers. The nail swelling rate(%) is calculated by using the nail weight of before and after experiment. The nails treated with penetration enhancer are fully dried and then we observed the surface of nails by using SEM and AFM. The three potential penetration enhancers showed high nail swelling rate and the surface of nails was more lifted than non-treating group or control group. So three penetration enhancers as enhancing the drug penetration are excellent.
만성 실질환 환자에서 허혈성 심질환에 대한 좌심실 이완기능 장애의 영향
최보경 ( Bo Kyung Choi ),이경남 ( Kyung Nam Lee ),황인혜 ( In Hye Hwang ),김일영 ( Ii Young Kim ),이하린 ( Ha Rin Rhee ),성은영 ( Eun Young Seoung ),송상헌 ( Sang Heon Song ),이동원 ( Dong Won Lee ),이수봉 ( Soo Bong Lee ),곽임수 대한내과학회 2012 대한내과학회지 Vol.83 No.3
Background/Aims: Cardiovascular complications are commonly seen in patients with chronic kidney disease (CKD). Recently, the prevalence of left ventricular diastolic dysfunction (LVDD) has increased, and the importance of LVDD has emerged in patients with CKD. The objectives of this study were to identify diagnostic criteria for LVDD related to ischemic heart disease (IHD) and evaluate the prognostic impact of diastolic dysfunction in patients with CKD. Methods: A total of 71 patients with CKD who were evaluated between January 2005 and May 2010 were included in this study. These patients were evaluated by conventional echocardiography and tissue Doppler imaging (TDI) for diastolic dysfunction. Results: Diagnostic cutoff values for LVDD related to IHD were E/E` = 15.55 (sensitivity: 100%, specificity: 64.7%, p = 0.005) and E/A = 0.79 (sensitivity: 84.6%, specificity: 55.9%, p = 0.006), Group I consisted of 19 patients with an E/E` > 15.55 and E/A > 0.79. Group II consisted of the remaining patients. Factors contributing to LVDD were age, history of ischemic heart disease, anemia, and high low-density lipoprotein (LDL) level. Factors contributing to IHD were LVDD, smoking, high LDL level, and high parathyroid hormone (PTH) level. The disease-free survival for IHD was significantly lower in group I compared to group II (p= 0.001). However, there was no significant difference in overall survival between groups I and II (p = 0.177). Conclusions: Our study showed that moderate LVDD (E/E` > 15.55 and E/A > 0.79) in patients with CKD is positively associated with IHD.
수용성 고분자에 따른 실로스타졸 고체분산체의 특성화 및 조절된 방출거동
박종학 ( Jong Hak Park ),김세호 ( Se Ho Kim ),오재민 ( Jae Min Oh ),안식일 ( Sik Il Ahn ),김윤태 ( Yun Tae Kim ),정수현 ( Su Hyun Jung ),최진희 ( Jin Hee Choi ),이동원 ( Dong Won Lee ),유일수 ( Il Sou Yoo ),이종문 ( John M Rhee ) 한국조직공학·재생의학회 2009 조직공학과 재생의학 Vol.6 No.4
The aim of this study was to improve dissolution rate and controlled release of poorly water-soluble drug, cilostazol, using general water soluble polymers. We prepared solid dispersed cilostazol with hydrophilic polymer, Poly-N-Vinylpyrolidone(PVP), Plasdone S630, Hydroxypropylmethylcellulose(HPMC), PEG 6000, Eudragit E100, and surfactant, Poloxamer 407. Characterization of cilostazol solid dispersion analyzed by scanning electron microscope(SEM), differential scanning calorimeter(DSC) and infrared spectrometry(FT-IR). SEM and DSC were found that amorphous in solid dispersion. Particle size analyzer was used to investigate size of cilostazol in solid dispersion. The in vitro release behavior of solid dispersion presented at simulated gastric fluid(pH 1.2). The release behavior of cilostazol was controlled release with hydrophilic polymers and solid dispersed cilostazol with hydrophilic polymers was sustained release behavior than initial burst release of commercial drug(Pletal(R)). This studies suggest that this solid dispersion system with hydrophilic polymers controlled poorly water-soluble drug, cilostazol, release behaviors.