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이동권(Dong Kwon Rhee),임창진(Chang Jin Lim),김두하(Doo Ha Kim),홍순근(Soon Keun Hong),박은희(Eun Hee Park),한용남(Yong Nam Han) 大韓藥學會 1982 약학회지 Vol.26 No.4
Acute toxicities of purified ginseng saponin (PGS) in mice, and subacute toxicities of PGS in rats were investigated. Average lethal doses (LD50) of PGS in male mice were 270mg/kg (i.v.), 342mg/kg (i.p.), 505mg/kg (i.m.), 950mg/kg (s.c.), and more than 5,000mg/kg (p.o.), respectively. Results of subacute toxicity of PGS was as follows. Body weight was markedly increased by administration of PGS 7.7mg/kg but side effects were shown by administration of 77mg/kg and above dose. Especially administration of PGS 240mg/kg caused a marked decrease of albumin/globulin ratio, and 28% increase of urea nitrogen in serum, as well as 33% increase of liver weight/body weight ratio.
Schima wallichii sp. liukiuensis 로 부터 분리된 β-Sitosterol Glycoside 항균물질의 안정성 및 돌연변이원성
이동권(Dong Kwon Rhee),최명석(Myung Suk Choi),신금(Keum Shim),권오웅(Oh Woung Kwon),손성호(Sung Ho Son) 한국응용약물학회 1999 Biomolecules & Therapeutics(구 응용약물학회지) Vol.7 No.3
Stability of the β-sitosterol glycoside from Schima wallichii sp. liukiuensis at various physical conditions were investigated, mutagenecity of the steroid saponin was determined by Ames test. When exposed in pH 3 to pH 8, the β-sitosterol glycoside was stable on antimicrobial activity against yeasts. The antimicrobial activity of the β- sitosterol glycoside also stable in high temperature, N₂, O₂ gas and light exposure, and metal ion. Ames test result revealed that (β-sitosterol glycoside did not have any mutagenic activity. These results suggest that the β-sitosterol glycoside might be a promising candidate as a natural antimicrobial compound.
혈청 농도가 다제내성 억제제 BIBW 22 의 nucleoside 수송에 미치는 영향
이동권(Dong Kwon Rhee),(Hong Xing Chen),(Uwe Bamberger),(Yung Chi Cheng) 한국응용약물학회 1995 Biomolecules & Therapeutics(구 응용약물학회지) Vol.3 No.2
Some multidrug resistance inhibitors have been known to be influenced by the serum concentration. In this study, effect of serum concentration on inhibition of nucleoside transport by BIBW22, a new multidrug resistance inhibitor derived from dipyridamole (DPM), was studied. When 5% or 100% (v/v) of fetal bovine serum (FBS) was contained in the culture, DPM dose for which nucleoside transport was inhibited by 50% (ID_(50)) was 0.42μM or 1.17μM, respectively. BIBW22 also showed the same trend as DPM did in response to increase of FBS concentration. However, ID_(50) value for DPM in the absence or presence of human plasma was 0.007μM or 1.02μM respectively showing 145times increase of ID_(50) value. ID_(50) value for BIBW22 in the presence of human plasma was 0.028μM showing only 5times increase in ID_(50) value. This result suggests that potency of BIBW22 was much less affected by the plasma concentration and BIBW22 could be a good candidate for a clinical use in multidrug resistance treatment.
이동권(Dong Kwon Rhee),문은이(Eun Yi Moon),표석능(Suhk Neung Pyo) 한국응용약물학회 1996 Biomolecules & Therapeutics(구 응용약물학회지) Vol.4 No.2
Aflatoxin B1 (AFB1) has been reported to directly suppress the immune responses. In the present study, the effect of AFB1 on immune functions was investigated. Splenic lymphocytes were treated with various doses of the mitogens (lipopolysaccharide, concanavalin A) in the presence of AFB1. AFB1 pretretment decreased the number of plague forming cells (PFC) in a dose-dependent manner. Antibody production of IgM and IgG class was significantly decreased in AFB1-treated splenic cells. In addition, when animals were exposed to AFB1, the susceptibility of bacterial infection as well as the growth of tumor cells was increased. These data suggest that AFB1 affected the immune function and humoral immunity impaired by AFB1 treatment contributed to pathological process.
흰쥐의 혈청 콜레스테롤 및 중성지방 수준에 미치는 인삼 총 사포닌의 영향
임창진,박은희,이동권,이송재,홍순근,Lim, Chang-Jin,Park, Eun-Hee,Rhee, Dong-Kwon,Lee, Song-Jae,Hong, Soon-Keun 생화학분자생물학회 1981 한국생화학회지 Vol.14 No.3
콜레스테롤을 과량 투여한 흰쥐에 정제된 인삼 총 사포닌을 용량별 및 경로 별로 투여하여 혈청 총 콜레스테롤 및 중성지방 수준에 마치는 영향을 검토하였다. 정상적인 흰쥐에서는 정제 총 사포닌의 투여 용량에 비례하여 혈청내 콜레스테롤이 감소되는 경향이 있었으며, 콜레스테롤을 과량 투여한 흰쥐에서는 총 사포닌 15 mg/kg을 경구 투여 함으로써 혈청내의 콜레스레롤양이 증가되었는데, 총사포닌 150 mg/kg을 경구투여 시에는 반대로 감소되었다. 콜레스테롤을 과량 투여한 흰쥐에 총 사포닌 15 mg 및 50 mg/kg을 복강내로 투여했을 때의 혈청내 콜레스테롤 함량은 같은 용량을 경구 투여했을 때의 콜레스테롤 함량과 비슷하였다. 콜레스테롤과 사포닌의 부분 가수분해 산물인 프로사포계닌 50 mg/kg을 경구 투여 했을 때의 혈청 콜레스테롤 수준은 콜레스테롤과 총 사포닌을 각각 500 mg/kg, 15 mg/kg을 동시에 경구 투여 및 복강내 주사 할 때와 유사하였다. 콜레스테롤과 총 사포닌을 동시에 투여한 흰쥐의 혈청내 중성지방수준은 콜레스테롤 단독 투여군에 비하여 다소 감소하였으나, 용량에 따른 차이는 인정되지 않았다. Effects of administration route and dose of ginseng total saponin on the levels of serum cholesterol and triglyceride in normal and cholesterol-administered rats were studied. The results are as follows: 1. In normal rats, serum cholesterol was decreased in proportion to the administered dose of purified total saponin. 2. In high-cholesterol administered rats, administration of total saponin 15 mg/kg (p.o.) increased serum cholesterol, but total saponin 150 mg/kg decreased it. And it was also observed that administration of prosapogenin 50 mg/kg had about the same effect as oral administration of total saponin 15 mg/kg. 3. Serum triglyceride was slightly decreased by administration of total saponin, but there was no correlationship between administered total saponin dose and serum triglyceride level.
손은화,박재현,김경란,김병오,이동권,표석능,Son, Eun-Wha,Park, Jae-Hyun,Kim, Kyung-Ran,Kim, Byung-O,Rhee, Dong-Kwon,Pyo, Suhk-Neung 한국생약학회 1998 생약학회지 Vol.29 No.1
The effects of Bezoar Bovis on immune responses of ICR Mice were studied. In the present study, the Jerne hemolytic plaque assay (PFC) was used to evaluate the humoral immune response to sheep red blood cells, and macrophage regulatory function was measured by quantitating the production of molecules secreted by macrophages. Bezoar Bovis was given in single daily p.o doses for short term (1, 2 days) or long term (7, 14 days). PFC response for taken 3 days after short term exposure to Bezoar Bovis was increased. The production of nitirc oxide in macrophages was also stimulated. In contrast, long term exposure to Bezoar Bovis resulted in inhibitory effect of Bezoar Bovis on nitirc oxide, $TNF-{\alpha}$and IL-6 production in macrophages. These findings suggest that treatment with Bezoar Bovis may result in differential immunological effect depending on treatment schedule.
Site - directed Mutagenesis 에 의한 대장균 치오레독신 유전자의 번역시작 돌연변이체 제조 : 대장균 치오레독신 유전자 번역의 또다른 시작
임창진,임은주,김영덕,이동권,홍순주 ( Chang Jin Lim,Eun Joo Lim,Young Deug Kim,Dong Kwon Rhee,Sun Joo Hong ) 생화학분자생물학회 1991 BMB Reports Vol.24 No.5
The mRNA produced from the E. coli thioredoxin gene (trxA) contains two potential translational initiation sites, one of which could initiate the synthesis of a protein 19 amino acids longer than the E. coli well-known thioredoxin of 108 amino acid residues. However, the expression of extended thioredoxin was not yet confirmed. To dissect translations from two initiation codons, the second ATG codon was converted to CTG by site-directed mutagenesis. The initiation-mutant thioredoxin gene lacking the second ATG codon could produce only the extended thioredoxin, which prove another translational initiation from the first ATG codon of an E. coli trxA mRNA. In vivo characteristics of the extended thioredoxin were examined in the several aspects. Just like the well-known thioredoxin, the extended thioredoxin is able to serve as a subunit of T7 DNA polymerase. In contrast, it doesn`t act as a cofactor for methionine sulfoxide reductase.
84 - kDa 의 폐렴구균 열충격단백질 CipL 의 Cloning 및 면역특성에 관한 연구
권혁영(Hyog Young Kwon),김용환(Yong Hwan Kim),최혜진(Hye Jin Choi),박연진(Youn Jin Park),표석능(Suhk Neung Pyo),이동권(Dong Kwon Rhee) 한국응용약물학회 2001 Biomolecules & Therapeutics(구 응용약물학회지) Vol.9 No.2
Heat shock proteins serve as chaperone by preventing the aggregation of denatured proteins and promote survival of pathogens in harsh environments. In this study, heat shock gene encoding a 84-kDa (p84) protein, which is one of the three major heat shock proteins in S. pneumoniae, was cloned and characterized. PCR with a forward primer derived from N-terminal amino acid sequence of the p84 and a reverse primer derived from the conserved second ATP-binding region of Clp family was used for amplification of the gene encoding the p84 and subsequently the PCR product was used for sequence determination. Sequence analysis of the p84 gene demonstrated that it is a member of ClpL. The deduced amino acid sequence of pneumococcal C1pL shows homology with other members of the Clp family, and particularly, even in variable leader region, with bovine Clp-like protein and L. lactis ClpL. S. pneumoniae clpL is the smallest clp member (701 amono acids) containing the two conserved ATP-binding regions, and hydrophilic N-terminal variable region of pneumococcal Clp ATPase is much shorter than any known Clp ATPases. Histidine tagged ClpL was overexpressed and purified from E. coli. Immunoblot analysis employing antisera raised against pneumococcus p84 demonstrated no cross-reactivity with Clp analog in Eschericha coli, Staphylococcus aureus and human HeLa cells. Preimmunization of mice with ClpL extended mice life partially but did not protect them from death.
권혁영(Hyog Young Kwon),이종호(Jong Ho Lee),이동권(Dong Kwon Rhee) 한국응용약물학회 1997 Biomolecules & Therapeutics(구 응용약물학회지) Vol.5 No.3
Since the advent of chemotherapy, certain types of cancer have been particularly resistant to chemotherapeutic treatment. One of the most well-studied types of resistance is resistance to multiple structurally dissimialr hydrophobic chemotherapeutic agents, or multidrug resistance (MDR). We found that MDR cells (KBV20C, KB7D) being highly resistant to colchicine, etoposide, and vincristine were found to have very low level of putrescine and low level of spermidine than the drug sensitive parental cells (KB) but they had almost same level of spermine as the drug sensitive cells. Although both MDR and drug sensitive cells had almost same rate of polyamine uptake, MDR cells were much more sensitive to an inhibitor of polyamine synthesis, methylglyoxal-bis guanylhydrazone (MGBG), suggesting that MDR cells might be defective in polyamine synthesis. These results also suggest that MGBG can be used for treatment of MDR in vivo.