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대식세포에서 Pneumococcal Teichoicated Fragment 에 의한 분비성 및 세포성 활성화의 유도
곽장동(Jang Dong Kwak),박숙영(Suk Young Park),신재용(Jae Yong Shin),손은하(Eun Hwa Son),이용화(Yong Hwa Lee),인용희(Yong Hee In),이동권(Dong Kwan Lee),표석능(Suhk Neung Pyo) 한국응용약물학회 2000 Biomolecules & Therapeutics(구 응용약물학회지) Vol.8 No.3
Bacterial components and their derivatives have been reported to mediate various immunomodulating activities and to activate immune cells including macrophage. In this study, the secretory and cellular macrophage response to teichoicated fragments (TFs) from pneumococcal cell wall subcomponent were examined. Tumoricidal activity was measured by MTT assay and secretory molecules were assessed by biological assay. After stimulation of macrophages with various doses of TFs for 18hrs, secretion of TNF-α, nitrite and H₂O₂ were significantly increased as compared to medium-treated control. In addition, tumorcidal activity of TFs-treated macrophages was enhanced, whereas production of IL-1 and IL-6, and phagocytic activity were not induced. These data suggest that TFs is a potent inducer of macrophage secretory and cellular activities.