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천선아,최병기,정춘식,이대위,이은방,Cheon, Seon-Ah,Choi, Byung-Kee,Jeong, Choon-Sik,Li, Da-Wei,Lee, Eun-Bang 한국생약학회 2000 생약학회지 Vol.31 No.2
From our previous report, the water extract of Pulsatilla koreana root was found to have potent anti-inflammatory and analgesic actions in intravenous administration in animals. Among chloroform, ethyl acetate, butanol and water fractions which were obtained through successive fractionation of the extract, only the water fraction was found to have the antiinflammatory and analgesic actions. The fraction did not affect normal body temperature at the effective doses in mice and showed low acute toxicity of which $LD_{50}$ was less than 500 mg/kg i.v. in mice. It is interesting that its anti-inflammatory action might be attributed in part to inhibition of cyclooxygenase-1 and -2.
이은방(Eun Bang Lee),조성익(Sung Ig Cho),이대위(Da Wei Li),현진이(Jin Ee Hyun) 한국응용약물학회 2001 Biomolecules & Therapeutics(구 응용약물학회지) Vol.9 No.3
N/A DKY is an oriental drug preparation composed of 17 natural products and is known to have antihyperglycemic action at 100 ㎎/㎏ po in animal tests. The general pharmacological properties of DKY preparation were investigate in mice, rats, guinea pigs and rabbits. This preparation did neither show any effects on central nervous system, nor effects on algesia, nor epilepsia at the large doses of 3000 ㎎/㎏ po in mice or rats. However, the preparation showed hypothermic action at the doses of 330 and 1000 ㎎/㎏ po. In the guinea pig ileum, rat fundus strip and estrogenized rat uterus, DKY did not influence their tension at a concentration of 3 X 10^(-3) g/㎖, and the spasmogenic actions produced by histamine, ACh and 5-HT were not blocked in the presence of DKY at 3 × 10^(-3) g/㎖. The blood pressure and respiration were not considerably influenced at 10㎎/㎏ iv of DKY in rabbits. It did not influence the intestinal propulsion of mice and the normal gastric secretion of rats. These results may suggest that DKY preparation have little effects on central nervous, autonomic and gastrointestimal systems, except hypothermic action.