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Fabrication of CTC-capturing Hydrogel Microparticle via Degassed Mold Lithography
이낙준,맹세정,황기태,봉기완 한국공업화학회 2019 한국공업화학회 연구논문 초록집 Vol.2019 No.1
Circulating tumor cell (CTC) detection technology is essential for isolating CTC, which is important biomarker of cancer, from blood by liquid biopsy. Since applying hydrogel microparticles in CTC detection has advantages in the point of customization, biocompatibility and cell culture, we optimize microparticles covered with optimized concentration of antibody against epithelial cell adhesion molecule to capture CTC. Improving previously published work, we introduce porositytuned, amplified-reaction site microparticles via controlling prepolymer composition and applying new fabrication technique called degassed mold lithography. Optimized micropariticles have optimal porosity and reactive terminal bonds for conjugating antibodies. Also, they capture CTC effectively with high affinity compared to previous works.
두경부 재건술 후 중환자실 환자 관리에 있어 미다졸람 기반의 진정 프로토콜과레미펜타닐 기반의 진정 프로토콜의 비교
이낙준,장전엽,최성용,박기남,백정환,박준서,박숙현,정한신 대한이비인후과학회 2014 대한이비인후과학회지 두경부외과학 Vol.57 No.3
Background and Objectives In head and neck reconstructive surgery, the stability of vital signs is important for patient recovery and flap outcome. We aimed to determine the better sedation protocol by comparing two protocols, namaely, midazolam/morphine (MM)-based and remifentanil (RF)-based sedation protocols, in the immediate postoperative settings of head and neck reconstructive surgery. Subjects and Method We retrospectively reviewed the medical data of patients who underwent reconstructive surgery after the ablation of head and neck cancer involving MM sedation (n=34) or RF sedation (n=28). Parameters related to vital signs, flap outcomes, occurrence of delirium, length of stay and nursing burden were compared between the groups. Results The length of stay at the intensive care unit and flap outcomes were similar in the two groups. However, blood pressure as measured by frequency of variation was more stable in the RF group than in the MM group. In addition, the number of medical calls from the attending nurse due to the fluctuation of vital signs was less in the RF group than in the MM group. Conclusion RF-based sedation for the postoperative intensive care unit care after head and neck reconstructive surgery is more effective in cases where vital signs are less stable. This type of sedation may decrease the nursing burden for these patients. Korean J Otorhinolaryngol-Head Neck Surg 2014;57(3):172-7
이낙준,조정규,김한결,윤영선,손영익,Lee, Nak-Joon,Cho, Jungkyu,Kim, Han-Kyeol,Yun, Young-Sun,Son, Young-Ik 대한후두음성언어의학회 2014 대한후두음성언어의학회지 Vol.25 No.2
Background and Objectives : Arytenoid adduction procedure is one of the main surgical options addressed for the correction of glottal incompetence in patients with unilateral vocal cord paralysis. Traditionally, a midline approach is used for identifying and suturing around the muscular process, which often needs over-traction of the thyroid cartilage and results in patient's discomfort as well as surgeon's distress. The authors investigated the advantage of a modified procedure, lateral approach, in which the arytenoid cartilage is exposed through the space between strap muscles and sternocleidomastoid muscle. Materials and Methods : Retrospective chart review was performed for 66 patients who received arytenoid adduction surgery at Samsung Medical Center, between the year 1997 and 2014. Operation time, types of anesthesia, voice outcomes and complications were compared between the midline (n=22) and the lateral (n=44) approach group. Results : Operation time was shorter in the lateral approach group ($125{\pm}24min$) than in the midline group ($144{\pm}24min$). Arytenoid adduction was proceeded under local anesthesia in 66% (n=29/44) and 14% (n=3/22) of patients with lateral and midline approach group, respectively. Voice outcomes and complication rates were comparable between the two groups. Injection laryngoplasty in conjunction with arytenoid adduction resulted in more favorable voice outcomes. Conclusion : A lateral approach for the arytenoid adduction procedure showed comparable voice outcomes and similar complication rates with those of a midline approach. However, lateral approach provided less discomfort to the patients and less distress to a surgeon, and therefore, shorter operation time was needed and local anesthesia could be more frequently applied for this modified procedure.
NOA microfluidic device fabrication via serial replica modling technique
이낙준,노윤호,정현욱,봉기완 한국공업화학회 2019 한국공업화학회 연구논문 초록집 Vol.2019 No.0
Although the polydimthylsiloxane (PDMS) microfluidic devices are frequently utilized in microfluidic applications, these devices have several problems such as short-term modified surface condition, swelling in the presence of organic solvents and deformation under high pressure. To solve these problems, Norland Optical Adhesive (NOA) has been presented as alternative material for microfluidic device to replace PDMS. Here, we introduce a practical protocol for the fabrication of NOA microfluidic devices via a serial molding process. By using indirect molding of NOA on positive-pattered wafers, we were able to prevent damage to the wafers and reduce fabrication cost of wafers. We test the performance of NOA devices in oil-in-water droplet production using organic solvents and confirmed that the devices fabricated by step-wise replica molding showed same performance compared with the devices fabricated with other methods.
Poly(N-vinyl caprolactam) hydrogel microparticle for controlled thermos-responsive drug release
이낙준,노윤호,김현웅,홍은지,심민석,봉기완 한국공업화학회 2019 한국공업화학회 연구논문 초록집 Vol.2019 No.0
For the realization of therapeutic efficacy, controlled drug delivery system is important. Here, we introduce Poly(N-vinyl caprolactam) (PVCL) microparticles for temperature-responsive drug delivery. PVCLbased microparticles were synthesized via Stop Flow Lithography (SFL) process. Polymer network in microparticles are contracted above certain temperature known as lower critical solution temperature (LCST) behavior. After setting the LCST close to body temperature by adding hydrophilic component, we conducted the drug release test using doxorubicin as a model drug. As a result, we revealed that the releasing rates of doxorubicin were significantly higher at above LCST. Using SFL, we fabricated multicompartmental PVCL microparticles and showed that more than two modes of drug release profile can be accomplished. Also, we carried out in vitro experiments and clarified the significantly increased anticancer activity according to the temperature difference.
이낙준,김영봉 釜慶大學校 1999 釜慶大學校 論文集 Vol.4 No.1
GIS often uses digital elevation model(DEM) to get three dimensional geographic information. For a three dimensional information from ordinary contour maps, several related works have been focused on recovery of disconnected contour segments by characters, digits, symbols and so on. Yang[2] suggested a method to connect the disconnected contour segments by setting up various axes starting from the center and analyzing the relationships between axes and contour segments. However, this method is quite inefficient because it makes many unnecessary axes. Thus, we propose an efficient method for recovering the contour segments using a fewer unmber of axes.