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간경변증에 동반된 비기능 항진증의 치료에 있어서 부분적 비동맥 색전술의 장기적 평가
이기창(Kee Chang Lee),함준수(Joon Soo Hahm),이종철(Jong Chul Rhee),이민호(Min Ho Lee),최일영(Il Young Choi),박경남(Kyung Nam Park),기춘석(Choon Suhk Kee),서흥석(Heung Suk Seo) 대한내과학회 1994 대한내과학회지 Vol.46 No.2
Background: Partial splenic embolization (PSE) was performed in ten cirrhotic patients with hypersplenism. Since Maddison first used splenic embolization in the treatment of hypersplenism in 1973, Spigos introduced partial splenic embolization with only few serious complication. Methods: The splenic artery was selectively catheterized via a femoral approach, and the tip of the catheter was placed as distal as possible at intrasplenic artery and gelfoam was infused. In this study, the mean infarcted area of spleen was approximate 60% of spleen. Six cases of ten patients were followed up to 42 months. Results: 1) The platelet and WBC counts increased immediately after P.S.E. Maximal count was observed at one month and then decreased gradually but maintained within normal limit until 42 months. 2) The hemoglobin level was not increased rapidly after P.S.E. but increased gradually and maintained within normal limit for 42 months. 3) The fever, abdominal pain were observed in all cases and transient ascites, pleural effusion ware observed in a few case but no serious complication was observed. Conclusion: P.S.E. is an effective alternative therapy for hypersplenistn in patients with liver cirrhosis.
Dihydro-1,4-oxathiin 유도체의 가수분해 Mechanism과 반응속도론적 연구
이광일,곽천근,장병만,김영주,한호규,남기달,이기창,Lee, Kwang Il,Kwak, Chun Geun,Jang, Byung Man,Kim, Young Ju,Hahn, Hoh Gyu,Nam, Kee Dal,Lee, Ki Chang 대한화학회 1996 대한화학회지 Vol.40 No.2
Dihydro-1, 4-oxathiin 유도체의 가수분해 반응속도를 25.deg.C의 수용액에서 자외선 분광기를 사용하여 측정하고 넓은 pH범위에서 적용될 수 있는 반응속도식을 유도하였다. 가수분해 반응속에에 미치는 치환기 효과를 검토하기 위하여 Hammett plot한 결과 전자 끄는기에 의하여 반응속도가 촉진됨을 확인할 수 있었다. 가수분해 최종 생성물은 2-(2-hydroxyethylthio)acetoacetanilide enol형이었다. 가수분해 반응속도상수 측정실험과 반응식 유도과장, 일반염기 효과, 치환기 효과 및 최종 생성물의 결과로부터 dihydro-1, 4-oxathiin 유도체의 기수분해 반응 메카니즘을 제안하였다. pH3.5이하에서는 양서자가 첨가된 dihydro-1, 4-oxathiin의 2번 탄소에 물분자의 공격에 의해 진행되며, pH3.5 이상에서는 2번 탄소에 히드록시이온의 첨가에 의하여 진행됨을 알 수 있었다. pH4.0-9.0사이에서는 dihydro-1, 4-oxathiin에 중성의 물분자가 첨가되는 것이 속도결정단계임을 알았다. The kinetics of the hydrolysis of dihydro-1, 4-oxathiin derivatives were investigated by ultraviolet spectrophotometry in H2O at $25^{\circ}C.$ A rate equation which can be applied over a wide pH range was obtained. The substituent effects on the hydrolysis of dihydro-1, 4-oxathiin derivatives were studied and the rate of hydrolysis was shown to be accelerated by electron accepting groups. Final product of the hydrolysis was 2-(2-hydroxyethylthio)acetoacet-anilide enol form. On the basis of rate equations derived and judging from hydrolysis products obtained and from general base effect and substituent effects, plausible mechanism of the hydrolysis in various pH range have been proposed. Below pH 3.5, the hydrolysis was initiated by the protonation and followed by the addition of water to 2-carbon. Above pH 10.0, the hydrolysis was proceeded by the addition of hydroxide to 2-carbon. In the range of pH 4.0∼10.0, the addition of water to dihydro-1,4-oxathiin is rate controlling step.
손정일 ( Chong Il Sohn ),김명곤 ( Myeong Kon Kim ),이기창 ( Kee Chang Lee ),정성수 ( Sung Soo Jung ),이인홍 ( In Hong Lee ),배상철 ( Sang Cheol Bae ),유대현 ( Dae Hyun Yoo ),김성윤 ( Seong Yoon Kim ),정화순 ( Wha Soon Chung ) 대한류마티스학회 1994 대한류마티스학회지 Vol.1 No.1
Eosinophilia is usually accompanied by parasite infestation, allergic condition, drug, collagen disease, and idiopathic hypereosinophilic syndrome. In about 10 to 40% of rheumatoid arthritis patients, peripheral blood reveals eosinophilia. Of the rheumatic disease, eosinophilia may occur in rheumatoid arthritis, sarcoidosis, polyarteritis nodosa and other vascultis. Patient with eosinophilia must be carefully followed up due to possibility of progression to eosinophilic leukemia or myeloproliferative disease. We experienced a case of rheumatoid arthritis with severe eosinophilia for a period of more than one year in a 53 year-old female patient, eosinophil more than 85% in the peripheral blood, but in spite of careful laboratory study, there was no evidence of parasite infestation, allergic disease and malignant condition that may cause eosinophilia. Therefore we concluded that her severe eosinophilia was associated with rheumatoid arthritis itself, and now she is intensively followed up at the outpatient department. We have to look for any malignant transformation during her clinical course. Marked eosinophilia associated with rheumatoid arthritis is very rare, so we report this case with a review of literatures.
성인경(In Kyung Sung),강인구(In Ku Kang),심승철(Seung Chul Shim),김종필(Jong Pil Kim),이기창(Kee Chang Lee),손정일(Chong Il Sohn),정철헌(Chul Hun Jung),박동일(Dong Il Park),이종철(Jong Chul Rhee) 대한내과학회 1994 대한내과학회지 Vol.46 No.3
Objectives: It has been proposed that patients with non-ulcer dyspepsia can be classified into symptom subgroups. Subgroups were as follows; those with symptoms suggestive of peptic ulceration (ulcerlike dyspepsia), those with gastric stasis (dysmotilitylike dyspepsia), those with gastroesophageal reflux (refluxlike dyspepsia), and the remainder (unspecified dyspepsia). Methods: The study population consisted of 306 patients with non-ulcer dyspepsia admitted to or attending to Hanyang University Hospital from the beginning of Feb. 1990 to the end of August 1992. We evaluated the gastrointestinal symptoms and measured gastric emptying time for 150min using radionuclide scintiscan of an 99mTc-labeled chicken liver. Results: 1) A total of 306 patients with diagnosed to non-ulcer dyspepsia, 54% had dysmotilitylike dyspepsia, 16% had ulcerlike dyspepsia, 2% had refluxlike dyspepsia and 10% had unspecified dyspepsia. 2) A total of 148 non-ulcer dyspepsia patients with normal gastric emptying time, 48% had dysmotilitylike dyspepsia, 19% had ulcerlike dyspepsia, 2% had refluxlike dyspepsia and 10% had unspecified dyspepsia. 3) A total of 158 non-ulcer dyspepsia patients with delayed gastric emptying time, 61% had dysmotilitylike dyspepsia, 14% had ulcerlike dyspepsia, 2% had refluxlike dyspepsia and 9% had unspecified dyspepsia. 4) Dysmotilitylike dyspepia was more commonly present in patients with delayed gastric emptying time than in patients with normal gastric emptying time(p<0.05) 5) There was a slight female predominance (1:1.3 male-female ratio) in non-ulcer dyspepsia patients with normal gastric emptying and peak incidence was 40 to 49 years of age (40%). 6) There was a female predominance (1:1.9 male-female ratio) in non-ulcer dyspepsia patients with delayed gastric emptying and peak incidence was 40 to 49 years of age(42%). 7) A total of non-ulcer dyspepsia patients, 35% had irritable bowel symptoms and the frequency of accompanied irritable bowel symptoms was statistically significant difference between the patients with normal gastric emptying time (46%) and the patients with delayed gastric emptying time (26%)(p<0.01). Conclusion: Among the non-ulcer dyspepsia patients in Korean, dysmotilitylike dyspepsia was most common subgroup and the refluxlike dyspepsia was very rare and 35% had irritable bowel syptoms.