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      • 미숙아의 제반사항 및 간호에 관한 임상적 고찰

        李君子 中央醫學社 1974 中央醫學 Vol.26 No.4

        This clinical study was done 85 premature infants among 803 new born babies delivered during three years from the January 1, 1971 to December 31, 1973 at the Department of Obstetrics and Gynecology of Inchon Provincial Hospital. The premature infants who weighed under 2500 gm were chosen as the subject ,of this study and as a result their related matters and considerations on clinical _nursing care were as follows. 1) The birth incidence of the premature infants was 10.6%. 2) The distinction of sex. in premature infants was 48 cases (56.5%) of female and 37 cases (43.5%) of male. 3) The birth weight of premature infants was 23 cases (27.0%) belong to the group of 2251-2500 gm which was the top, and the average birth weight was 1915.5 gm in male and 1898.4 gm in female, therefore their both average birth weight was 1907 gm. It showed that the male weighed more than, the female by 17.1 gin and as they weighed more their numbers increased. 4) The number-of the twins in. the premature infants was 14 cases (16.5%). 5) The birth length of premature infants was 48 cases (68.3%) were under 47 cm and the 7 cases (8.2%) were over 50 cm. 6) The gestation period of premature infants was 55 cases (64.7/) were under 37 weeks and 20 cases (23.5%) were over 40 weeks. 7) The mothers who gave birth to premature infants were from 26 to 30 years old and the number of them was topped by 30 cases (38.0%). 8) The mothers who had maternal diseases in the period of-pregnancy were 39 cases (49. 4%) and no problems or others were 40 cases (50.6%). Judging from what it revealed, toxemia was the greatest . in number by 15 cases (19.0%). 9) The parity of premature infants was the first babies were the greatest in number by 38 cases (44.7%'). It indicated that the higher in parity, the lower in number. 10) Monthly delivery number of premature infants was 28 cases (32.9%) topped in figure were born from March to May. 11) The delivery type of premature infants was .27 cases (31.88%) topped in number were extracted by vacuum. 12) The mothers who gave birth to, premature infants was 49 cases (62.0%) had not received prenatal care and 30 cases (38.00) had. 13) The dead of premature infants was 15 cases (17.7%).

      • 京畿道 地域에서 自動車事故로 인한 死亡 및 負傷

        李君子 서울大學校保健大學院 1975 公衆保健雜誌 Vol.12 No.2

        This study was aimed to disclose the magnitudes and trends of deaths and injuries from motor vehicle accidents with the relations to several factors such as population, number of vehicles, roads's conditions and size of area. Raw data were collected from the various available sources of local government. Main data related to incidence, deaths and injuries were obtained from the records of Department of Police in Gyung-gi Province for 4 years period from 1971 to 1974. The following was summary of the results made with the analysis of the data collected: 1. The total events of motor vehicle accidents in Gyung-gi area for 4 years were 18,140 cases. The annual average rates of incidence, death and njury per 100,000 population were 124.5, 13.6 and 160.6 repectively. The above rates were higher in the urban area than in the rural area. On the other hand, the rates of incidence, death and injury tend to decrease annually. 2. The age specific rates of deaths and injuries per 100,000 population were 10.0 and 79.2, respcetively in the ages under 14, whereas 15.8 and 209.8, respectively in the ages above 15. Among total numbers of death and injured, the age group of under 14 constituted 27.7% and 18.6%, respectively. 3. The everage incidence of motor vehicle accidents per 1,000 vehicles registered was 297.7 events and the number of the death and the injured were 32.4 and 383.5 persons per 1,000 vehicles, respectively. 4. The average incidence, death and injury per 100,000 meters of road's length were 105.1 cases, 11.5 and 135.6 persons, respectively. The above averages were higher in the urban than in the rural areas. 5. The average incidence, death and injury per 100km²of area were 41.4 cases, 4.5 and 53.4 persons, respectively. These averages also were larger in the urban than in the rural areas. 6. Setting the values in 1971 as baseline index 100, population, number of vehicles and population density were steadily increased, but both of events and rates per population of incidence, death and injury were decreased in cases and rate per 100,000 population, and there were no definite changes in road's length and size of area. 7. The average numbers of the death and the injured from motor vehicle accidents were 109.0 and 1,289 persons per 1,000 accidents, respectively. On the other hand death versus injury was average 1:11.8. 8. The daily average of motor vehicle accidents in incidence was 12.4 events, that of death and injured were 1.4 and 16.0 persons, respectively. It Showed that the number of accidents was the greatest in July and August. 9. There were no definite differences in the incidence of motor vehicle accidents by the week days, but they happened somewhat more on Sunday and Monday. 10. The motor vehicle accidents occurred most frequently in the 12:00-18:00 o'clock by time. 11. The causes of motor vehicle accidents were classified 95.1% of drivers fault, 2.9% of pedestrians faults, 2.0% of poor maintenance.

      • Mitomycin C투여에 의한 공막의 조직병리학적 연구

        이군자 서울保健大學 1996 論文集 Vol.16 No.1

        익상편 수술 후 재발 방지를 위하여 사용되고 있는 MMC를 안구의 성장이 활발한 어린 흰쥐에게 점안한 후 나타나는 공막의 조직학적 및 조작 화학적인 변화를 관찰하여 다음과 같은 결과를 얻었다. 1) 저농도(0.04mg/mL)의 MMC를 점안한 공막에서는 조직학적인 변화를 관찰할 수 없었으나, 고농도(0.1mg/mL) 의 MMC를 3일간 점안한 실험군과 7일간 점안한 실험군에서는 공막실질의 아교섬유의 간격이 상당히 벌어졌으며 이러한 조직 손상은 MMC 점안을 중지한 후에도 완전히 회복되지 않았다. 2) 고농도(0.lmg/mL)의 MMC를 점안한 실험군의 공막실질에서 alkaline phosphatase 활성은 약간 감소하였으며, MMC 투여 후 7일이 경과한 경우에도 효소활성이 회복되지 않았다. 3) 저농도(0.04mg/mL) 및 고농도(0.lmg/mL)는 MMC를 점안한 실험군의 공막실질에서 섬유모세포와 제I형 아교질 항체에 대한 반응은 대조군에 비하여 감소하였으며, MMC 점안 후 7일이 경과한 실험군에서도 제I형 아교질항체에 대한 반응은 회복되지 않았다. 4) 저농도의 MMC를 1회 점안한 실험군, 3일간 점안한 실험군, 접안 후 7일 경과군 및 고농도의 MMC를 1회 투여한 실험군의 공막실질에서는 Cu, Zn-SOD 활성이 관찰되었으나, 고농도의 MMC를 장기간 점안한 실험군과 점안 후 7일이 경과한 실험군에서는 활성이 관찰되지 않았다. 이상과 같은 결과로 MMC를 점안한 흰쥐의 공막실질에서는 일시적으로 Cu, Zn-SOD 의 활성이 증가하여 MMC에 의한 조직독성을 일부 줄일 수 있을 것으로 생각되나, MMC를 계속 점안한 경우에는 alkaline phosphatase 활성이 감소하고 아교섬유의 합성능력이 감소하여 공막실질의 아교섬유가 정상적인 판(lamella) 을 형성하지 못하여 공막괴사 등의 부작용이 나타나는 것으로 생각되며, 고농도의 MMC를 점안한 경우에는 점안을 중지한 후에도 공막에 조직독성이 나타나는 것으로 생각된다. Mitomycin C(MMC), widely used as an adjunct in the surgical treatment of pterygium, was instilled to the young rats to evaluate the histologic and histopathologic toxicity of the sclera. 1. Significant histologic changes were not detected in the lower dose of MMC(0.04mg/mL) treated groups, but lamella structure of sclera was irregular in the higher dose of MMC(0.1mg/ mL) treated groups. These structural changes were not recovered within 7days after ceasation of MMC instillation. 2. Alkaline phosphatase activity was decreased in the higher dose of MMC treated groups, and it was not recovered within 7 days after ceasation of MMC instillation. 3. Type I collagen and type I collagen synthetic activity of fibroblast were decreased in the lower and higher dose of MMC treated groups, and these changes were not recovered within 7 days after ceasation of MMC instillation. 4. Cu, Zn-SOD activity was increased in the lower dose of MMC treated groups and single application of higher dose of MMC, but Cu, Zn-SOD activity was not detected in the other higher dose of MMC treated groups. These results indicate that increase of Cu, Zn-SOD activity may reduce the MMC toxicity temporarily, but repeated MMC treatment changes the sclera irregular by decreasing biosynthesis of collagen in the fibroblast. These irregular lamella structure may lead to necrotizing scleritis.

      • KCI등재

        콘택트렌즈 착용자가 사용하는 식염수의 세균오염 상태

        이군자 대한시과학회 2003 대한시과학회지 Vol.5 No.1

        콘택트렌즈 관리용액의 세균오염은 안과질환을 유발할 수 있다고 보고되었다. 우리 나라에는 용량이 큰 식염수를 콘태트렌즈 관리에 사용하고 있어 방부제가 포함된 식염 수 1 종과 무방부제 식염수 2종을 대상으로 안전성을 조사하였다. 콘택트렌즈 착용자 120명을 대상으로 식염수를 3일에서 3주 동안 사용하도록 지시 한 후 사용한 식염수의 일부를 취하여 BHI 배지에서 배양하였다. 배양된 세균의 16S rRNA는 중합효소반웅(PCR) 과 자기염기서열분석기를 이용해 분석하였으며, nucleotide database의 BLAST program올 이용하여 비교 분석하여 동정하였다. 실험에 사용한 120 병의 식염수 중 오염된 식염수는 49병으로 (45%) 나타났고, 오염 도는 방부제가 포함된 식염수에서는 최고 66,000 CFU/ml, 무방부제 식염수에서는 최 고 180,α)()CFU/ml로 나타났다. 오염 된 균주는 Achromobacter xylosoxi따15, Alcaligenes sputorum, Pseudomonas huttiensis. Stap따locoCiα'Js epidermidis, Pseudomonas huttiensis, Achromobacter xylosoxidαIS 맞 Pseudomonas aeruginosa 둥 총 27 개 균종이 검 출되 었다. 식염수는 방부제 포함 유무에 상관없이 개봉 후 오염되기 시작하여 시간이 경과하 면 오염도가 급격히 증가하는 것으로 나타났으며, 오염된 세균은 대부분 기회감염 또 는 병원감염에 관련된 세균으로 결막염, 각막염, 각막궤양, 안내염올 유발하는 균주로 조사되었다. Ocular infection has been reported in contact lens patients using contarninated contact lens care solutions. Contact lens wearers use large volume saline solutions in Korea, we investigated the contarnination of one preserved and two unpreseπed saline solutions after use. One hundred twenty subjects participated in this study. Saline solutions had been used for 3 days to 3 weeks. Control and test saline solutions were placed on a BHI media and cultured at 37'C for 48 hrs. We used PCR method to obtain 16S rRNA base sequence of the bacteria, and compared nucleotide sequence by using BLAST prograrn to identify the contaminated bacteria in the test saline solutions. Contamination of the test saline solutions occurred in 49 of the 120 bott1es tested (45%) , and the level of contarnination of these bott1es ranged up to 66,000 CFU/ml in the preserved saline solution and 180,000 CFU/ml in the unpreserved saline solution. We identified total 27 different bacteria including Achromobacter xylosoxidans, Alcaligenes sputorum, Pseudomonas huttiensis, Stap버lococcus epidermidis, Pseudomonas huttiensis, Achromobacter xylosoxidans and Pseudomonas aeruginosa in the contaminated saline solutions. We concluded that preserved and unpreserved saline solutions could be contaminated after opening and bacterial contarnination could be increasing with the using period. And contaminated bacteria in the test saline was infectious. and opportunistic infectious bacteria that are associated with microbial conjuntivitis, keratitis, comeal ulcer and endophthalmitis.

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