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광간섭 단층 영상기술을 이용한 생체 내 microneedle삽입 구조 영상
김훈 ( Hun Kim ),허정 ( Jung Heo ),이강주 ( Kang Ju Lee ),유수호 ( Su Ho Ryu ),유원형 ( Won Hyoung Ryu ),주철민 ( Chul Min Joo ) 정보저장시스템학회 2013 정보저장시스템학회논문집 Vol.9 No.1
Optical coherence tomography (OCT) allows non-invasive, cross-sectional optical imaging of biological tissue with high spatial resolution and acquisition speed. In principle, it is analogous to ultrasound imaging, but uses near-infrared light instead of ultrasound, measuring the time-delay of back-scattered light from within biological tissue. Compared to ultrasound imaging, it exhibits superior spatial resolution (1∼10 um) and high sensitivity. Therefore, OCT has been applied to a wide range of applications such as cellular imaging, ophthalmology and cardiology. Here, we describe a novel application of OCT technology in visualizing microneedles embedded in tissue that is developed to deliver drugs into the dermis without the injection mark in the human skin. Detailed three-dimensional structural images of microneedles and biological tissues were obtained. Examining structural modification of microneedles and tissues during insertion process would enable to evaluate performance of various types of microneedles in situ.