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만성 비세균성 전립선염 환자의 전립선액에서 interleukin-1β의 변화
윤하나,이동현 대한요로생식기감염학회 2011 Urogenital Tract Infection Vol.6 No.1
Purpose: To measure changes in prostate cytokine secretion in chronic non-bacterial prostatitis (NBP) patients and examine the clinical usefulness of these changes in differentiating the pathophysiologic mechanism of NBP and subsequent selection of treatment modalities. Materials and Methods: Sixty male patients were diagnosed with chronic NBP, and a control group comprised of 30 male patients without clinical evidence of NBP were enrolled in this study. Prostate secretion (centrifuged VB3) was analyzed at the initialdiagnosis and 8 weeks after treatment initiation. Patients who showed more than 10 white blood cells (WBCs)/high power field (HPF) 8 weeks after treatment initiation were categorized into group A. Group B patients had less than 3 WBCs/HPF. Group B was further subclassified into two groups according to presence of symptoms after treatment: Bp (symptom-persisted) and Br (symptom-resolved). IL-1β, C3, C4, IgG were measured and the results were analyzed. Results: There were significant differences in the IL-1β level in the control group compared to group A, Bp and Br (p<0.05). C3, C4, IgG showed higher levels in groups A and B than in the control group, albeit without statistical significance (p>0.05). Conclusions: Elevated IL-1β in group Bp suggests that chronic NBP patients who did not respond to treatment could exhibitclinical manifestations of autoimmune reactions rather than infection of external origin. We suggest that a more advanced diagnostic technique using cytokine at the initial stage of disease manifestation tohelp clinicians avoid unnecessary antibiotic treatment and manage the condition more effectively.
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윤하나,박광성 대한의사협회 2016 대한의사협회지 Vol.59 No.2
In female sexual dysfunction (FSD), psychological and contextual factors significantly influence organic components of sexual response and behavior. The hormonal environment also affects FSD. Therefore, a tailored medical approach to each individual’s sexual symptom is inevitable. This paper reviews currently available pharmacological treatment of FSD including the most recent advances and future targets in pharmacotherapy. In hormonal therapies for FSD, efficacy of estrogens and androgens on the treatment of vaginal atrophy, low sexual desire, and small subsets of genital arousal disorder, respectively, have been demonstrated. However, we need more data regarding long-term safety. There are two non-hormonal agents approved by the US Food and Drug Administration. Flibanserin has shown marginal benefit over placebo for the treatment of hypoactive sexual desire disorder. Ospemifen has shown beneficial effect on vulvovaginal pain from hormone related atrophy although it requires a longer period data to assess safety in other female genital organs, such as uterus and ovaries. Controversies still remain regarding hormonal therapies for FSD. Besides, some of the developing drugs still require more reliable safety and efficacy data. However, pharmacologic treatment of FSD is a promising field yet to be explored.
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한부모가족과 재혼가족에 대한 태도 연구 : 성별, 연령, 미디어 장르 요인을 중심으로
윤하나,이강형,김수정 한국소통학회 2021 한국소통학보 Vol.20 No.3
다양한 가족 형태가 등장하고 규범적 핵가족 관념이 해체되면서 ‘가족 다양성’ 수용 이 한국사회의 중요한 시대적 과제로 부상하고 있다. 그러나 다문화가족을 제외하고는 다양한 형태의 가족 연구를 찾아보기 힘든 실정이다. 이에 본 연구는 성별, 연령, 그리 고 미디어 장르에 따라, 한부모가족과 재혼가족에 대한 개인들의 태도(인식, 정서, 행 동)에 어떠한 차이가 나타나는지를 2000명의 온라인 서베이 조사를 통해 알아보았다. 연구 결과, 성별, 연령, 미디어 장르에 따라 두 가족 유형에 대한 태도는 차이를 보였다. 구체적으로 살펴보면, 첫째, 남성은 한부모가족과 재혼가족에 대해 여성보다 더 부정적 인 인식과 정서를, 행동의도에서는 더 긍정적인 태도라는 양가적 결과를 나타냈다. 둘 째, 연령에서는, 10-20대가 30-60대에 비해 한부모가족과 재혼가족에 대해 긍정적 인식 과 정서를 보였다. 셋째, 미디어 장르의 영향에서는, 예능 장르는 재혼가족에만, 다큐멘 터리·교양은 재혼가족과 한부모가족 모두에 ‘사회 부적응성’이라는 부정적 인식 효과 를 나타냈다. 정서에 미치는 효과에서는, 드라마·영화가 한부모가족에 대한 ‘불편감’을 다소 감소시키는 반면, 예능 장르는 한부모가족과 재혼가족 모두에 대해 부정적 정서를 증가시켰다. 행동의도에서는, 다큐멘터리·교양이 한부모가족과 재혼가족에 대한 사회 적 조력 동참의도를 증가시키는 반면, 예능은 관계 맺기나 사회적 조력 측면 모두 부정적 영향을 보였다. 한편, 뉴스·시사 장르에 노출은 한부모가족에 대해 관계맺기 회피 와 사회조력 행위 동참의향을 동시에 강화하는 이중적 결과를 보였다. 미디어 장르 효 과에서, 연령과 성별의 조절효과는 극히 일부만 유의미한 결과를 나타냈다. The acceptance of ‘family diversity’ has become an important contemporary task in times that various types of family appear and that the normative conception of the nuclear family gradually breaks down. Unfortunately however, there is little research on that issue except for the case of multicultural families. This study examined how individual attitudes(perceptions, emotion, behavior) toward single-parent families and remarried families vary according to variables of sex, age, and media genre, based on a survey of 2,000 individuals via online. The findings are as follow. First, toward both types of families. male respondents show more negative perception and emotion while more positive behavioral intention more than female ones Second, compared to respondents in their 30s, respondents in their teenagers and 20s more positive perception and emotion toward two types of families. Third, as for the variables of the media genres, the entertainment genre has negative effects on the perception of single-parent families while documentary genres on that of both types of family. With regard to emotion, the drama genre reduces ‘uncomfortable feeling’ toward on-parent families while the entertainment genre has negative effects toward both types of families. As for behavioral intention, the documentary genre increases the intention of social aid participation toward both types of families while the entertainment genre has negative effects on that of social relationship as well as social aids. As for news and current affair genres reveal ambivalent results of strengthening the intentions of both the avoidance of social relationship and the social aids.
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