여성 성기능장애의 호르몬 보충치료

윤하나 대한남성과학회 2012 The World Journal of Men's Health Vol.30 No.1

Female sexual function is highly complex and deeply influenced by hormonal and non-hormonal factors. As sexual dysfunction becomes a common and important problem for women of all ages with related quality of life issues, we need to understand more about the effect of sex steroid hormones in female sexual function. However, there are limited data about the correlation between the value of sex steroid hormones- testosterone, in particular-and female sexual function. In a certain type of female sexual dysfunction (FSD), hypoactive sexual desire disorder, for example, there is evidence that treatment with androgens or with estrogens is effective. To widen the therapeutic options of hormone replacement therapy in FSD, further research is needed as to the benefits and risks of hormonal treatments in both pre- and post-menopausal women. Although important unanswered questions still exist in hormonal treatment of FSD, new therapeutic strategies are being studied and many ongoing clinical trials are expecting favorable results leading to more successful treatment of FSD.

방광의 만성 질환: 과민성방광과 방광통증증후군/사이질방광염

윤하나 대한의사협회 2021 대한의사협회지 Vol.64 No.11

Background: Overactive bladder (OAB) and interstitial cystitis/bladder pain syndrome (IC/BPS) are debilitatingchronic bladder diseases that affect patients’ quality of life. Their etiologies and clinical phenotypes vary, and management strategies should be selected after excluding the possibilities of other pathological conditions with careful consideration of a multidisciplinary integrated approach to ensure optimal success. Current Concepts: OAB is a symptom complex characterized by urinary urgency and frequency and nocturia with or without urge incontinence, and its key symptom is urinary urgency. IC/BPS has symptoms similar to lower urinary tract symptoms (LUTS) associated with OAB but also has distinctly different symptoms, including the key symptom of an unpleasant sensation or pain perceived to be related to the urinary bladder associated with LUTS. Recent studies have revealed that these key symptoms of OAB or IC/BPS are also observed in some patients with other diseases. Patients showing no evidence of bacterial infection on urine culture and experiencing LUTS or pain for more than 6 weeks should be considered as having OAB or IC/BPS. Treatment strategies for OAB and IC/BPS focus on managing LUTS and bothersome pain. Noninvasive management should be considered initially, whereas surgical options should be considered only after conservative treatment failure. Discussion and Conclusion: OAB and IC/BPS symptoms overlap considerably in many patients. A more accurate differentiation of symptoms, including LUTS, would help achieve better treatment outcomes.

국소 침윤성 방광이행상피암(T3a/T3b)에서 M-VAC 항암화학요법의 효과

윤하나,채상균,전훈석,박원식,최학룡,윤희수 大韓泌尿器科學會 1998 Korean Journal of Urology Vol.39 No.12

Synthesis and Applications of Noble Metal and Metal Silicide and Germanide 1-Dimensional Nanostructures

윤하나,Youngdong Yoo,서관용,Juneho In,김봉수 대한화학회 2012 Bulletin of the Korean Chemical Society Vol.33 No.9

This review covers recent developments in our group regarding the synthesis, characterization and applications of single-crystalline one-dimensional nanostructures based on a wide range of material systems including noble metals, metal silicides and metal germanides. For the single-crystalline one-dimensional nanostructures growth, we have employed chemical vapor transport approach without using any catalysts, capping reagents, and templates because of its simplicity and wide applicability. Au, Pd, and Pt nanowires are epitaxially grown on various substrates, in which the nanowires grow from seed crystals by the correlations of the geometry and orientation of seed crystals with those of as-grown nanowires. We also present the synthesis of numerous metal silicide and germanide 1D nanostructures. By simply varying reaction conditions, furthermore, nanowires of metastable phase, such as Fe5Si3 and Co3Si, and composition tuned cobalt silicides (CoSi, Co2Si, Co3Si) and iron germanides (Fe1.3Ge and Fe3Ge) nanowires are synthesized. Such developments can be utilized as advanced platforms or building blocks for a wide range of applications such as plasmonics, sensings, nanoelectronics, and spintronics.

한국 여성의 성생활 양태 및 성기능 장애의 양상

윤하나,정우식,홍재엽,박영요,유은희,김종현 大韓泌尿器科學會 2001 Korean Journal of Urology Vol.42 No.1

사회부과 완벽주의와 이상섭식행동의 관계: 인지왜곡을 통한 마른 이상적 체형 내면화의 조절된 매개효과

윤하나,김은정 한국청소년학회 2021 청소년학연구 Vol.28 No.8

The purpose of the current study was to investigate whether cognitive distortion would mediate the relationship between socially prescribed perfectionism and abnormal eating behavior, and if such mediating effect would differ depending on the level of thin-ideal internalization. A total sample of 217 female undergraduate students completed measures assessing for socially prescribed perfectionism, cognitive distortion, abnormal eating behavior and thin-ideal internalization. The data was analyzed using SPSS Macro. The main results were as follows. First, cognitive distortion had a full mediating effect on the relationship between socially prescribed perfectionism and abnormal eating behavior. Second, thin-ideal internalization moderated the association between socially prescribed perfectionism and cognitive distortion. That is, as thin-ideal internalization increased, the effect of socially prescribed perfectionism over cognitive distortion increased. Third, the moderated mediating model was supported in that the mediating effect of cognitive distortion on the relationship between socially prescribed perfectionism and abnormal eating behavior increased as thin-ideal internalization increased. Limitation and future directions were discussed. 본 연구는 여자 대학생을 대상으로 사회부과 완벽주의와 이상섭식행동의 관계에서 섭식관련 인지왜곡이 매개하는지, 마른 이상적 체형 내면화가 이러한 매개효과를 조절하는지 알아보기 위해 SPSS를 활용하여 조절된 매개모형을 분석하였다. 217명의 여자 대학생을 대상으로 사회부과 완벽주의, 섭식관련 인지왜곡, 이상섭식행동, 마른 이상적 체형의 내면화를 측정하였다. 그 결과, 첫째, 인지왜곡은 사회부과 완벽주의와 이상섭식행동 간의 관계를 완전 매개하였다. 둘째, 사회부과 완벽주의와 이상섭식행동의 관계에서 마른 이상적 체형의 내면화의 조절효과가 나타났다. 즉, 마른 이상적 체형에 대한 사회문화적 기준을 내면화할수록 사회부과 완벽주의가 이상섭식행동에 미치는 영향이 증가하였다. 셋째, 조절된 매개효과가 나타났는데, 마른 이상적 체형의 내면화 수준이 높은 사람은 사회부과 완벽주의 수준이 높을수록 인지왜곡을 발달시켜 이상섭식행동에 취약해지지만, 내면화 수준이 낮은 사람은 사회부과 완벽주의 수준이 높더라도 인지왜곡을 발달시키지 않아 이상섭식행동에 취약하지 않다는 것이다. 끝으로 본 연구의 의의, 제한점 및 후속연구를 위한 제언에 대해 논의하였다.

Effect of Stress on the Expression of Rho-Kinase and Collagen in Rat Bladder Tissue

윤하나,이동현,전계민,윤현석,유재영 대한비뇨의학회 2010 Investigative and Clinical Urology Vol.51 No.2

Purpose: We examined the effect of stress on the pathophysiology of bladder stability in terms of enzyme levels, Rho-kinase, and bladder relaxation. Materials and Methods: A total of 48 female Sprague-Dawley rats were studied in scheduled stress environments for 7, 14, and 28 days; 24 rats were in the control group and 24 rats were in the test (stressed) group. Results: Estrogen decreased significantly whereas testosterone and dopamine increased significantly in the stress group (p<0.05). Rho-kinase was significantly increased in the rats exposed to stress stimuli for 14 days (p<0.05). Collagen types I and III in the bladder tissue were significantly higher in rats exposed to stress for 14 days and 28 days (collagen type I in the 14-day group, p<0.01; collagen type I in the 28-day group, p<0.05; collagen type III in the 14-day and 28-day groups, p<0.05). Voiding frequency increased significantly as the duration of stress exposure was prolonged, in addition to a significant decrease in volume per voiding (p<0.05). Conclusions: The changes observed in micturition pattern, factors that contribute to smooth muscle contraction, and relaxation in the female rat bladder support the hypothesis that stress affects bladder stability. Purpose: We examined the effect of stress on the pathophysiology of bladder stability in terms of enzyme levels, Rho-kinase, and bladder relaxation. Materials and Methods: A total of 48 female Sprague-Dawley rats were studied in scheduled stress environments for 7, 14, and 28 days; 24 rats were in the control group and 24 rats were in the test (stressed) group. Results: Estrogen decreased significantly whereas testosterone and dopamine increased significantly in the stress group (p<0.05). Rho-kinase was significantly increased in the rats exposed to stress stimuli for 14 days (p<0.05). Collagen types I and III in the bladder tissue were significantly higher in rats exposed to stress for 14 days and 28 days (collagen type I in the 14-day group, p<0.01; collagen type I in the 28-day group, p<0.05; collagen type III in the 14-day and 28-day groups, p<0.05). Voiding frequency increased significantly as the duration of stress exposure was prolonged, in addition to a significant decrease in volume per voiding (p<0.05). Conclusions: The changes observed in micturition pattern, factors that contribute to smooth muscle contraction, and relaxation in the female rat bladder support the hypothesis that stress affects bladder stability.

여성 성기능장애의 약물치료

윤하나,박광성 대한의사협회 2016 대한의사협회지 Vol.59 No.2

In female sexual dysfunction (FSD), psychological and contextual factors significantly influence organic components of sexual response and behavior. The hormonal environment also affects FSD. Therefore, a tailored medical approach to each individual’s sexual symptom is inevitable. This paper reviews currently available pharmacological treatment of FSD including the most recent advances and future targets in pharmacotherapy. In hormonal therapies for FSD, efficacy of estrogens and androgens on the treatment of vaginal atrophy, low sexual desire, and small subsets of genital arousal disorder, respectively, have been demonstrated. However, we need more data regarding long-term safety. There are two non-hormonal agents approved by the US Food and Drug Administration. Flibanserin has shown marginal benefit over placebo for the treatment of hypoactive sexual desire disorder. Ospemifen has shown beneficial effect on vulvovaginal pain from hormone related atrophy although it requires a longer period data to assess safety in other female genital organs, such as uterus and ovaries. Controversies still remain regarding hormonal therapies for FSD. Besides, some of the developing drugs still require more reliable safety and efficacy data. However, pharmacologic treatment of FSD is a promising field yet to be explored.

한부모가족과 재혼가족에 대한 태도 연구 : 성별, 연령, 미디어 장르 요인을 중심으로

윤하나,이강형,김수정 한국소통학회 2021 한국소통학보 Vol.20 No.3

다양한 가족 형태가 등장하고 규범적 핵가족 관념이 해체되면서 ‘가족 다양성’ 수용 이 한국사회의 중요한 시대적 과제로 부상하고 있다. 그러나 다문화가족을 제외하고는 다양한 형태의 가족 연구를 찾아보기 힘든 실정이다. 이에 본 연구는 성별, 연령, 그리 고 미디어 장르에 따라, 한부모가족과 재혼가족에 대한 개인들의 태도(인식, 정서, 행 동)에 어떠한 차이가 나타나는지를 2000명의 온라인 서베이 조사를 통해 알아보았다. 연구 결과, 성별, 연령, 미디어 장르에 따라 두 가족 유형에 대한 태도는 차이를 보였다. 구체적으로 살펴보면, 첫째, 남성은 한부모가족과 재혼가족에 대해 여성보다 더 부정적 인 인식과 정서를, 행동의도에서는 더 긍정적인 태도라는 양가적 결과를 나타냈다. 둘 째, 연령에서는, 10-20대가 30-60대에 비해 한부모가족과 재혼가족에 대해 긍정적 인식 과 정서를 보였다. 셋째, 미디어 장르의 영향에서는, 예능 장르는 재혼가족에만, 다큐멘 터리·교양은 재혼가족과 한부모가족 모두에 ‘사회 부적응성’이라는 부정적 인식 효과 를 나타냈다. 정서에 미치는 효과에서는, 드라마·영화가 한부모가족에 대한 ‘불편감’을 다소 감소시키는 반면, 예능 장르는 한부모가족과 재혼가족 모두에 대해 부정적 정서를 증가시켰다. 행동의도에서는, 다큐멘터리·교양이 한부모가족과 재혼가족에 대한 사회 적 조력 동참의도를 증가시키는 반면, 예능은 관계 맺기나 사회적 조력 측면 모두 부정적 영향을 보였다. 한편, 뉴스·시사 장르에 노출은 한부모가족에 대해 관계맺기 회피 와 사회조력 행위 동참의향을 동시에 강화하는 이중적 결과를 보였다. 미디어 장르 효 과에서, 연령과 성별의 조절효과는 극히 일부만 유의미한 결과를 나타냈다. The acceptance of ‘family diversity’ has become an important contemporary task in times that various types of family appear and that the normative conception of the nuclear family gradually breaks down. Unfortunately however, there is little research on that issue except for the case of multicultural families. This study examined how individual attitudes(perceptions, emotion, behavior) toward single-parent families and remarried families vary according to variables of sex, age, and media genre, based on a survey of 2,000 individuals via online. The findings are as follow. First, toward both types of families. male respondents show more negative perception and emotion while more positive behavioral intention more than female ones Second, compared to respondents in their 30s, respondents in their teenagers and 20s more positive perception and emotion toward two types of families. Third, as for the variables of the media genres, the entertainment genre has negative effects on the perception of single-parent families while documentary genres on that of both types of family. With regard to emotion, the drama genre reduces ‘uncomfortable feeling’ toward on-parent families while the entertainment genre has negative effects toward both types of families. As for behavioral intention, the documentary genre increases the intention of social aid participation toward both types of families while the entertainment genre has negative effects on that of social relationship as well as social aids. As for news and current affair genres reveal ambivalent results of strengthening the intentions of both the avoidance of social relationship and the social aids.

만성 비세균성 전립선염 환자의 전립선액에서 interleukin-1β의 변화

윤하나,이동현 대한요로생식기감염학회 2011 Urogenital Tract Infection Vol.6 No.1

Purpose: To measure changes in prostate cytokine secretion in chronic non-bacterial prostatitis (NBP) patients and examine the clinical usefulness of these changes in differentiating the pathophysiologic mechanism of NBP and subsequent selection of treatment modalities. Materials and Methods: Sixty male patients were diagnosed with chronic NBP, and a control group comprised of 30 male patients without clinical evidence of NBP were enrolled in this study. Prostate secretion (centrifuged VB3) was analyzed at the initialdiagnosis and 8 weeks after treatment initiation. Patients who showed more than 10 white blood cells (WBCs)/high power field (HPF) 8 weeks after treatment initiation were categorized into group A. Group B patients had less than 3 WBCs/HPF. Group B was further subclassified into two groups according to presence of symptoms after treatment: Bp (symptom-persisted) and Br (symptom-resolved). IL-1β, C3, C4, IgG were measured and the results were analyzed. Results: There were significant differences in the IL-1β level in the control group compared to group A, Bp and Br (p<0.05). C3, C4, IgG showed higher levels in groups A and B than in the control group, albeit without statistical significance (p>0.05). Conclusions: Elevated IL-1β in group Bp suggests that chronic NBP patients who did not respond to treatment could exhibitclinical manifestations of autoimmune reactions rather than infection of external origin. We suggest that a more advanced diagnostic technique using cytokine at the initial stage of disease manifestation tohelp clinicians avoid unnecessary antibiotic treatment and manage the condition more effectively.