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      • KCI등재

        Clinical Characteristics of Multiple Primary Colorectal Cancers

        윤주원,이승현,안병권,백승언 대한암학회 2008 Cancer Research and Treatment Vol.40 No.2

        Purpose: Although multiple primary colorectal cancer has been recognized as a significant clinical entity, its clinical and pathological features and its prognosis are still controversial. The purpose of this study was to clarify clinical and pathological features of multiple primary colorectal cancer. Materials and Methods: Among 1669 patients who underwent surgery for primary colorectal cancer from January 1997 to June 2005, 26 patients (1.6%) with multiple primary colorectal cancer were identified. We reviewed clinical characteristics including diagnostic interval, lesions, operating methods, and TNM stage, and we defined the index lesion as the most advanced lesion among the synchronous lesions. For the purposes of the study, the colon and rectum were classified into three segments. The right-side colon included the appendix, cecum, ascending colon, hepatic flexure, and transverse colon, and the left-side colon included the splenic flexure, descending colon, and sigmoid colon. Results: Of the 26 patients with multiple primary colorectal cancers, nineteen patients were male and seven patients were female, with a mean age of 61.5 years. Nineteen patients had synchronous colorectal cancers and seven patients had metachronous colorectal cancers. In the metachronous cases, the mean diagnostic interval was 36.8 months. The site of the first lesion in metachronous colorectal cancers was the right colon in five cases (71.4%) and the left colon in two cases (28.6%), and the site of the second lesion was the rectum in six cases (55.5%), the right colon in three cases (33.3%), and the left colon in one case. The TNM stage of the second lesions in the metachronous colorectal cancers was stage II in four cases (57.1%), stage III in one case (14.3%), and stage IV in one case (14.3%). For the synchronous colorectal cancers, the operation methods were single-segment resection combined with endoscopic mucosal resection in five cases (26.3%), single- segment resection alone in six cases, two-segment resection in six cases, and total colectomy in two cases. Conclusion: In metachronous colorectal cancers, the secondary lesions were later-stage cancer. Therefore, careful postoperative follow-up is necessary for patients who have undergone surgery for colorectal cancers. Further study of therapeutic modalities is important for synchronous colorectal cancers.

      • KCI등재후보
      • KCI등재

        Effect of Coloring Agent on the Strength and Transmittance of Dental Zirconia Block

        윤주원,이충재,이명구 대한예방치과학회 2017 International Journal of Clinical Preventive Denti Vol.13 No.4

        Objective: The purpose of this study is to compare and evaluate the fracture resistance and transmittance of several types of zirconia for CAD/CAM. Four types of zirconia blocks including specimens with coloring agents were used for this study. Methods: Forty specimens were prepared in total, 5 pieces each. The biaxial flexural bending strength and transmittance measurement using D65 light source were compared to investigate its characteristics, and XRD and SEM images of each specimen were used to observe the phase change and microstructure. ISO 6872 is the current standard used for evaluating the physical and mechanical properties of zirconia dental materials is. In the biaxial flexural strength test, the block specimen diameter was 20 mm and the specimen thickness was measured with a precision of 1 mm. Results: The transmittance of the prepared specimens was lowered by an average of 10% after applying the coloring agent, but not by block. In this axial flexural strength test, the increase of 80 to 100 MPa was observed in the other zirconia blocks excluding the Trans Blocks. Conclusion: There was no statistically significant difference between the materials. It was found to be statistically significant only in High Shine Blocks.

      • KCI등재

        The Analysis of the Effects of Physical Activity on Impaired Fasting Glucose in Adults Over 20 Years of Age

        윤주원 대한통합의학회 2023 대한통합의학회지 Vol.11 No.2

        Purpose : The purpose of this study was to investigate the effects of physical activity on impaired fasting glucose in adults aged 20 years or older. Methods : This study utilized raw data from the 8th National Health and Nutrition Examination survey (2019~2021). The subjects of this study were 5,344 adults aged 20 years or older who were confirmed to be free of diabetes. The control variables in this study model are health behavior characteristics (subjective health status, smoking, drinking), anthropometric characteristics (body mass index), and personal background characteristics (gender, age, income level, education level, marital status). As for the analysis method, the degree of physical activity was made into a dummy variable, and a probit model was used. Results : As a result of this study, compared to quartile 1 of the relative grip strength value obtained by dividing the grip strength by the body mass index (body mass index, ㎏, ㎡), fasting blood glucose levels were significantly higher in quartile 2 (.05, p<.01), quartile 3 (.04, p<.01), and quartile 4 (.04, p<.01). It was found that the probability of belonging to the normal category was higher than that of impaired fasting glucose. In addition, in the group of adults aged 20 or older who had a lot of aerobic and anaerobic physical activity, fasting blood sugar was more likely to be in the normal category. Conclusion : Based on the results of this study, it was suggested that diabetes should be managed through physical activity in the pre-diabetic stage, as prevention is important as well as treatment. From a practical point of view, muscle strength, such as grip strength, can be identified as a reliable indicator for identifying impaired fasting glucose.

      • KCI등재

        Panel Data Analysis of Lifestyle Factors, Metabolic Syndrome Risk, and Dementia in Aging Koreans

        윤주원 한국보건복지학회 2023 보건과 복지 Vol.25 No.3

        This study explored the link between metabolic syndrome risk factors and dementia in Korea using national aging panel data from the 8th Korean Longitude Study of Ageing. With a sample of 341 individuals, a structural equation model assessed the relationship between BMI, health behavior, subjective health status, high blood pressure, diabetes, and dementia levels. Significant associations were found between physical measurements, health behavior, subjective health status, high blood pressure, diabetes, and dementia levels, with high blood pressure and diabetes acting as mediators. Managing these conditions through lifestyle improvements and treatment is crucial for reducing dementia risk. The study's use of representative data enhances generalizability, but limitations include missing variables and observational constraints, emphasizing the need for future research integrating multiple data sources for a comprehensive understanding of the metabolic syndrome-dementia relationship.

      • KCI등재

        광역동 치료가 Streptococcus Mutans Biofilm에 미치는 효과에 관한 메타분석

        윤주원 한국콘텐츠학회 2023 한국콘텐츠학회논문지 Vol.23 No.3

        본 연구의 목적은 메타분석(meta analysis)을 통해 광역동 치료가 뮤탄스 연쇄상구균(Streptococcus mutans)에 미치는 효과 차이를 살펴보기 위함이다. 이를 통해, 광역동 치료에서 광감각제를 선택할 때 기준이 될 수 있는 정보를 제공하고자 하였다. 본 연구 방법은 R software 4.1 version의 “netmeta” 패키지를 활용하여 메타분석을 시행하였다. 본 연구의 주요 연구 결과는 커큐민(Curcumin), 메틸렌 블루(Methylene blue), 톨루이딘 블루 오르토(Toluidine blue ortho), 인도시아닌 그린(Indocyanine green), 에리트로신(Erythrosine) 순으로 뮤탄스 연쇄상구균에 대한 사멸 효과가 다름을 파악할 수 있었다. 이를 통해, 본 연구는 광역동 치료가 뮤탄스 연쇄상구균에 미치는 효과에 대하여 안정적이고, 신뢰성 있는 결과를 제시함으로써, 추후 다양한 광감각제에 따른 광역동 치료 개발에 유용한 기준과 방향을 제시하였다.

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