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히스티딘 중합체가 일차배양 기도 상피세포에서의 뮤신 유리에 미치는 영향
전병규(Byeong Kyou Jeon),윤인대(In Dae Yun),이재우(Jae Woo Lee),이충재(Choong Jae Lee) 대한약학회 2010 약학회지 Vol.54 No.5
We investigated whether poly-L-histidine (PLH) significantly affect mucin release from cultured airway epithelial cells. Confluent primary hamster tracheal surface epithelial (HTSE) cells were metabolically radiolabeled with 3H-glucosamine for 24 hr and chased for 30 min in the presence of PLH to assess the effect on 3H-mucin release. PLH 9,850 and PLH 6,700 specifically inhibit mucin release from airway goblet cells without significant cytotoxicity. This finding suggests that poly-L-histidine might function as an airway mucoregulative agent.