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        홍삼 비사포닌 분획물의 항불안 및 항우울에 대한 효과

        이범준 ( Beom Joon Lee ),김정우 ( Jung Woo Kim ),지은영 ( Eun Young Ji ),윤승연 ( Seung Youn Yun ),이상명 ( Sang Myung Lee ),류재환 ( Jae Hwan Lew ) 대한본초학회 2009 大韓本草學會誌 Vol.24 No.4

        Objectives: Anxiety and depression are stress-related disorders. Their prevalence are increasing rapidly. Ginseng is the root of Panax ginseng C.A. Meyer (Araliaceae) which has been used for many centuries in asian region. Anxiolytic effect is one of the popular effects of ginseng. Several studies reported saponin fraction of ginseng, including ginsenoside, is a major ingredient of anxiolytic effect. In present study, we investigated anxiolytic-like and antidepressant-like effect of non-saponin fraction in mice. Material and Method: Mice were divided into five groups. Experimental groups were administered non-saponin fractions (25 mg/kg; nsp25, 50 mg/kg; nsp50, 100 mg/kg; nsp100) respectively once a day in the morning at 9am for 1 week. Then, we performed elevated plus-maze (EPM) test for investigating the anxiolytic-like effect and forced swimming test (FST) for investigating the antidepressant-like action. Results: Non-saponin fraction 50 mg/kg group increased frequency and time spent (p<0.05) in open arm on EPM test and decreased immobility time (p<0.05) on FST compared with control group. Conclusions: We suggest that non-saponin fraction has anxiolytic-like effect and antidepressant like effect in mice.

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