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Veronica incana 추출물의 생물학적 활성 평가
신미래 ( Mi-rae Shin ),윤미영 ( Mi Yeong Yoon ),김민주 ( Min Ju Kim ),정일하 ( Il-ha Jeong ),안희연 ( Hui Yeon An ),정지원 ( Ji-won Jung ),노성수 ( Seong-soo Roh ) 대한본초학회 2024 大韓本草學會誌 Vol.39 No.3
Objectives : The aim of this study is to evaluate the potential biological activity of Veronica incana extracts (VIE) through in vitro, ex vivo, and in vivo experiments. Methods : In vitro, we conducted analyses on the total polyphenol (TP) and total flavonoid (TF) levels, alongside DPPH and ABTS radical scavenging activities. Ex vivo evaluations on adipose tissue measured glycerol release as a marker of lipolysis. In LPS-induced RAW 264.7 cells, we quantified nitric oxide (NO) production. Following H2O2 induction in U2OS cells, we performed mitochondrial assays such as MitoSox and MitoTracker. Moreover, Bodipy assays were conducted in 3T3-L1 cells. In vivo, we performed anti-osteoarthritis effect of VIE against monosodium iodoacetate (MIA)-induced osteoarthritis in rats. Results : The results presented encompass a myriad of models, from cell culture to animal experiments as well as ex vivo studies. VIE demonstrated high TP and TF contents, potent DPPH and ABTS scavenging activities, and regulated glycerol release. Moreover, the inhibition of NO production in LPS-induced inflammation was notably confirmed and the reduction of lipid droplets was distinctly shown. Furthermore, in H<sub>2</sub>O<sub>2</sub>-induced U2OS cells, MitoSox was effectively reduced while MitoTracker noticeably increased. In vivo assays confirmed a significant increase in hindpaw weight distribution (HWD) decreased by MIA after VIE treatment. Additionally, VIE inhibited serum inflammatory cytokines (TNF-α, IL-6, and IL-1β) and MDA levels in joint tissue. Conclusion : In conclusion, Veronica incana exhibited various pharmacological effects including antioxidant, anti-obesity, and anti-inflammatory properties.
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모발염색제 성분인 초산납에 대한 어성초 추출물의 항산화 및 미백효과
정재윤 ( Jai Yun Jung ),오영희 ( Young Hee Oh ),박신희 ( Shin Hee Park ),윤미영 ( Mi Young Yoon ),표애자 ( Ae Ja Pyo ),김선주 ( Sun Ju Kim ),유영월 ( Yeong Wol Yu ),정인주 ( In Ju Jung ) 대한미용학회 2014 대한미용학회지 Vol.10 No.2
To evaluate the antioxidative and whitening effects of Houttuynia cordata Thunb (HCT) extract on lead acetate (LA), hair dye component, cell viability was measured by colorimetric assay after NIH3T3 fibroblasts were cultured in media containing various concentrations of LA. And also, the effect of antioxidant, vitamin E on LA-induced cytotoxicity was analysed. For the protective effect of HCT extract on LA-induced cytotoxicity, NIH3T3 fibroblasts were pretreated with 110 or 130 μg/mL of HCT extract for 2 h before the treatment of LA. And also, the antioxidative and melanogenic effects of HCT extract were assessed by superoxide dismutase (SOD)-like activity, total amount of melanin and tyrosinase activity. In this study, LA significantly decreased cell viability in dose-dependent manner. And the XTT50 value was calculated at 48.3 μM of LA. In the effect of antioxidant, vitamin E, it effectively prevented LA-induced cytotoxicity by the significant increase of cell viability. In the protective effect of HCT extract on LA-induced cytotoxicity, HCT extract significantly increased cell viability which was decreased by the cytotoxicity induced by LA, and also it showed the antioxidative effect by SOD-like activity. In the melanogenesis, HCT extract showed the decreased of amount of melanin and tyrosinase activity. From these results, it is suggested that the cytotoxicity of LA is involved in oxidative stress, and HCT extract effectively prevented the cytotoxicity and the melanogenesis induced by LA.
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피부염 유발제인 삼산화크롬(CrO3)으로 손상된 배양 NIH3T3 섬유모세포에 대한 조개나물 추출물의 항산화 효과
정재윤 ( Jai Yun Jung ),오성균 ( Seung Kyun Oh ),박신희 ( Shin Hee Park ),윤미영 ( Mi Young Yoon ),유영월 ( Yeong Wol Yu ),임요섭 ( Yo Sup Rim ),정인주 ( In Ju Jung ) 대한미용학회 2014 대한미용학회지 Vol.10 No.1
This study was to evaluate the protective effect of Ajuga multiflora BUNGE(AMB) extract on the cytotoxicity induced by chromium trioxide (CrO3), dermatitis inducer. For this study, the cytotoxicity induced by CrO3 was assessed by colorimetric assay after NIH3T3 fibroblasts were cultured in media containing various concentrations of CrO3. And also, the effect of vitamin E was assessed on the CrO3-induced cytotoxicity. For the protective effect of AMB extract on CrO3- induced cytotoxicity, NIH3T3 fibroblasts were pretreated with 60 or 80 μg/mL of AMB extract for 2 hours, and also, antioxidative effects of ABM extract were analysed via electron donating ability (EDA) and lactate dehydrogenase (LDH) activity. In this study, CrO3 significantly decreased cell viability in a dose-dependent manner, and the XTT50 value was calculated at 28.4 μM. In the effect of vitamin E, it significantly increased cell viability decreased by CrO3-induced cytotoxicity. In the protective effect of AMB extract on CrO3-induced cytotoxicity, it significantly increased cell viability which was decreased by CrO3-induced cytotoxicity, and also it showed EDA and LDH inhibitory activity. From these results, it is suggested that the cytotoxicity of CrO3 is involved in oxidative stress, and also, AMB extract effectively prevented CrO3-induced cytotoxicity by the antioxidative effect. Conclusively, the natural plant component like AMB may be a putative agent for the prevention of the cytotoxicity induced by dermatitis inducer correlated with oxidative stress.
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