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비스포스포네이트 제제 관련 관절통 및 근육통에 대한 지역 약국 약사 및 환자 능동적 모니터링
송정우,박소희,윤동원,이모세,이정민,김나영,김영욱,이주연,신주영,Song, Jung-woo,Park, So-Hee,Yoon, Dongwon,Lee, Mo-Se,Lee, Jung-Min,Kim, Na-Young,Kim, Young-Wook,Lee, Ju-Yeun,Shin, Ju-Young 한국임상약학회 2021 한국임상약학회지 Vol.31 No.3
Objective: We investigated arthralgia and myalgia associated with the use of oral bisphosphonate (BP) by conducting a survey of patient. Methods: The pharmacists conducted a survey between 1 Oct 2019 and 30 Sep 2020 among patients who were dispensed BP in community pharmacies to assess their demographic and medical characteristics, and their experiences with, and process for pain. Logistic regression analyses were performed to find the risk factors associated with the pain, and the odds ratios (OR) and 95% confidence intervals (CI) were determined. Results: A total of 160 patients who used BP participated in the survey (74 [46.3%] used risedronate; 61 [38.1%] used alendronate; 23 [14.4%] used ibandronate), and 20 (12.5%) of them experienced pain. Significant statistical differences of the characteristics between patients who experienced pain or not were observed regarding menopause, and parity. Compared with women who had one or two parity, women who had more than three parity were associated with the decreased risk of pain (OR, 0.24; 95% CI, 0.04-0.98). Moreover, steady exercise was associated with the decreased risk of pain compared to less exercise (OR, 0.37; 95% CI, 0.14-0.98). Conclusion: Our findings suggest that the risk of pain in BP-treated patients might be different regarding the different ingredients of BP, and dosing frequency. This survey highlights a need for a further safety research to understand the factors influencing the pain associated with the BP treatment.
인플릭시맵 바이오시밀러 도입 이후 TNF-α 억제제 사용 변화 및 지출 영향 분석
노윤하(Yunha Noh),윤동원(Dongwon Yoon),신주영(Ju-Young Shin) 대한약학회 2020 약학회지 Vol.64 No.1
Tumor necrosis factor α (TNF-α) inhibitor, biologics for immunosuppression, is widely used for various kinds of autoimmune disease and it has contributed to improving patients’ prognosis. With the expiration of its patent, biosimilars have emerged since September 2012 in South Korea. The competitive cost of biosimilars can lead to significant impact on national health insurance finance. Thus, we aimed to estimate budget impact of the introduction of infliximab biosimilar. Overall trends of utilization and expenditure among TNF-α inhibitors were presented using the National Health Insurance Service-National Sample Cohort database, between May 2011 and December 2013. We conducted segmented regression of interrupted time series analysis to evaluate impact of biosimilar introduction. Utilization and expenditure of TNF-α inhibitor had generally increased during study period. Both quantitative usage and drug expenditure of infliximab biosimilar have significantly increased, while those of etanercept have decreased, since the introduction of infliximab biosimilar. The estimated expenditure savings due to the introduction of infliximab biosimilar was about 52 billion won, which greatly contributed to the reduction of the price of the infliximab original rather than the reduction from the use of infliximab biosimilar. In conclusion, the introduction of biosimilar presented substantial savings of expenditure. Further study will be needed to assess comprehensive impact of other biosimilars introduction.
수치해석적 방법에 의한 국내⋅외 기준에 따른 지하공동구 배연기류 적정성 평가
김동규(Kim, Dongkyu),윤동원(Yoon, Dongwon),안병천(Ahn, Byungcheon) 한국방재학회 2017 한국방재학회논문집 Vol.17 No.3
지하공동구의 화재는 지상화재에 비해 인명구조, 피난, 연소 확대 방지 등 소방대원의 소방 활동에 많은 제약을 받게 되며, 연기의 확산은 지상의 계단 방향으로 흐르므로 피난 방향과 동일하여 인명피해가 많이 발생 가능성이 매우 높다. 따라서 본 연구에서는 지하공동구 화재발생 시, 연기확산 시나리오의 검토와 국내⋅외의 기류속도 설계기준과의 비교 분석과 컴퓨터 시뮬레이션을 이용한 지하공동구의 배연성능을 위한 시뮬레이션 연구 등이 이루어졌다. 연구 결과로서 컴퓨터 시뮬레이션을 통해 중간지점 화재 시 기류속도에 따른 대상 지하공동구의 기류속도와 비교한 결과, 대상 지하공동구의 설계 풍량에 따른 기류속도는 설비구 0.45m/s와 전력구 0.54m/s로 국내기준 2.5m/s와 국외기준 2.0m/s에 크게 못 미치는 것으로 나타났다. A fire in the underground tunnel gives significant restrictions to the fire-fighting activities of fire fighters such as the rescue of human lives, evacuation and prevention of combustion spread in comparison to a fire on the ground, and smoke spreads in the direction of stairs on the ground which is same as the evacuation direction so that there is a high possibility that many casualties may occur. Therefore, this study was carried out in order to review a scenario to spread fire inside the underground utility tunnel in the event of a fire and also the assesment of ventilation performance of underground tunnel with the domestic and international standards was done by using computer simulation. As a result, the design airflow velocity criterion of domestic and external underground tunnels was investigated and compared. The design airflow velocity of an underground tunnel for utility pipe and power cable tunnels was 0.45m/s and 0.54m/s respectively, which are far below the domestic standard of 2.5m/s and the international standard of 2.0m/s??.
김보라(Bora Kim),윤동원(Dongwon Yoon),신주영(Ju-Young Shin) 대한약학회 2021 약학회지 Vol.65 No.5
As vaccines are administered to many people, the management of adverse reactions to vaccines should be a priority. This study aims to detect signals of adverse events following immunization to provide information on the events requiring attention. The Korean Adverse Event Reporting System database from 2010 to 2019 was used. Time series, status, and signal analyses were performed. The number of adverse events following immunization from 2010 to 2019 was determined. A comparison group was established considering the main vaccination targets for each vaccine. Signal information was detected that satisfies all four signal detection methods: proportional reporting ratio, reporting odds ratio, information component, and TreeScan. From 2010 to 2019, the number of adverse events following immunization reported was 37,688. The vaccines having the most reported adverse events were influenza (17,290 cases, 45.9%). Because of identifying the signal information of the top-10 vaccines based on adverse events, 74 adverse events were identified in 6 vaccines. The results are expected to contribute to the prevention of adverse events by providing information on adverse events following immunization requiring attention.