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강정대 ( Kang Jeong Dae ),김소진 ( Kim So Jin ),윤녕훈 ( Yun Nyeong Hun ),박석돈 ( Park Seog Don ) 대한피부과학회 2003 대한피부과학회지 Vol.41 No.11
Cutaneous extramedullary plasmacytomas are rare in patients with multiple myeloma, they usually indicate a large tumor cell burden and fatal outcome. A 55-year-old man presented with multiple cutaneous tender nodules or masses on whole body. A biopsy specimen of cutaneous nodule showed dermal infiltration by well differentiated plasma cells. Many atypical and immature plasma cells were found in a bone marrow smear and biopsy. A serum protein electrophoresis revealed elevated quantities of Ig G-globulin with type 入 light chain. The patient was treated with VAD(vincristine, adriamycin, dexamethasone) chemotherapy, but died with pulmonary edema and acute respiratory distress syndrome. We report a fatal case of multiple myeloma first presenting as multiple extramedullary cutaneous plasmacytomas. (Korean J Dermatol 2003;41(11) : 1517∼1520)