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유한동,심우영,허충림 대한화학요법학회 1992 대한화학요법학회지 Vol.10 No.2
Terbinafine is an allylamine antifungal agent with a primarily fungicidal action in vitro. Its spectrum includes dermatophyte, filamentous, dimorphic and dermaticaceous fungi and some yeast species. Terbinafine inhibits squalene epoxidation. The treated fungi accumulate squalene while becoming deficient in ergosterol, and essential component of fungal cell membrane. The cidal activity of terbinafine is closely related with the increased intracelluar squalene concentraion. But in the case of candida albicans, growth inhibition with terbinafie apperars to result from ergosterol deficiency. We experienced a patient with onychomycosis of fingernail caused by candida albicans. He was treated with terbinafine 250㎎ daily for 8 weeks. After completion of therapy, fingernail showed complete recovery and we could not see any laboratory abnormalities or adverse reactions.
유년기에 발생한 Porokeratotic eccrine ostial and dermal duct nevus 1 예
유한동 대한피부과학회 2000 대한피부과학회지 Vol.38 No.7
Porokeratotic eccrine ostial and dermal duct nevus is considered to be a rare congenital hamartoma of eccrine duct origin. Histopathologic studies showed multiple cornoid lamella-like parakeratotic columns, which were associated with hyperplastic eccrine ostia and distal sweat ducts. I describe the case of a 20-year-old man with childhood-onset porokeratotic eccrine ostial and dermal duct nevus. He had a 10-year history of multiple keratotic papules and comedo-like pits on the thenar area and thumb of the right hand. But in my case, immunohistochemical studies for carcinoembryonic antigen showed no association with eccrine ostium and adjacent cornoid lamella-like structures.