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유익원,황호연,김태훈,이상학 대한이비인후과학회 2008 대한이비인후과학회지 두경부외과학 Vol.51 No.8
Spindle cell (sarcomatoid) carcinoma of the upper respiratory tract is a rare malignancy, and its diagnosis, treatment, and prognosis still remain controversial. Histopathologic examination of this uncommon tumor shows surface epithelialcarcinoma and an underlying spindle-shaped proliferation. In the head and neck region, it is found predominantly in the larynx and oral cavity. To our knowledge, spindle cell carcinoma of the paranasal sinus has been rarely reported. We report a 57-year-old woman with a spindle cell carcinoma originating from the maxillary sinus. She was treated with surgery and post operative radiotherapy. After 8 months of close follow-up, she shows no sign of recurrence or distant metastasis. We offer this case and a review of the related literature in an effort to increase awareness of this rare malignancy. (Korean J Otorhinolaryngol-Head Neck Surg 2008;51:747-50)
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1.5 cm 이하 크기의 갑상선 유두상암종의 임상적 양상
유익원,정은재,백승국,정광윤,김신곤 대한이비인후과학회 2009 대한이비인후과학회지 두경부외과학 Vol.52 No.7
Background and Objectives With the increasing use of high resolution sonography and fine needle aspiration biopsy, the proportion of newly diagnosed thyroid papillary carcinomas have increased. However, it is not entirely clear whether microcarcinomas detectable by the above technology the should be considered a threshold for risk evaluation. The purpose of this study is to evaluate the clinical behavior of papillary carcinomas smaller than 1.5 cm. Subjects and Method A retrospective chart review was conducted for 181 patients who underwent surgery for thyroid cancer and was proven to have papillary carcinoma smaller than 1.5 cm in size from 1997 to 2006. The patients were divided into 3 groups according to cancer size. The patient’s gender, age, surgical method, pathology, initial neck node and neck recurrence was analyzed by chi-square test, analysis of variance (ANOVA) test and multinomial logistic regression analysis. Results Progressively increasing frequency of signs of tumor aggressiveness (multifocal, bilateral, extracapsular spread) was observed with increasing size. The rate of lymph node metastasis increased also, but it did not reach a significant value. Despite the increasing rate of aggressiveness and lymph node metastasis, there was no significant difference in recurrence between these groups. Conclusion Although the long term outcome does not seem to directly depend on tumor size in these small thyroid cancers, a progressing frequency of aggressiveness with increasing cancer size at presentation is evident.
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전신성 홍반성 루푸스 환자의 양측 이하선에서 발생한 MALT 림프종
전형진,유익원,정광윤,백승국 대한이비인후과학회 2009 대한이비인후과학회지 두경부외과학 Vol.52 No.6
Malignant lymphoma of salivary gland is rare and takes 2-5% of all neoplasm of salivary glands. Mucosa-associated lymphoid tissue (MALT) lymphoma is known as a unique subtype of Non-Hodgkin’s lymphoma. Since MALT lymphoma tends to be an indolent and localized disease, complete surgical resection is able to be performed as a single treatment. In this article, we present a case of MALT lymphoma in both parotid glands of the patient with systemic lupus erythematosus, who underwent both superficial parotidectomy.
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Validation of a Korean Version of the Tinnitus Handicap Questionnaire
전형진,유익원,황선진,황순영 대한이비인후과학회 2015 Clinical and Experimental Otorhinolaryngology Vol.8 No.3
Objectives. The goal of the present study was to evaluate the reliability and validity of the Korean version of the tinnitus handicap questionnaire (THQ-K). Methods. A total of 60 patients were included in this study. Patients responded to the THQ-K, the tinnitus handicap inventory (THI), Beck’s depression index (BDI), and the visual analogue scale (VAS) for loudness and pitch, loudness match, and minimum masking level (MML) test were performed. Results. Internal consistency of the THQ-K was examined using Cronbach coefficient alpha. Cronbach alpha was 0.96. The THQ-K showed a significant correlation with THI, BDI, VAS for distress, and VAS for loudness, but no significant correlation with psychoacoustic measurement of tinnitus, such as loudness match, pitch match, and MML. Conclusion. The THQ-K is a reliable and valid test for evaluating the degree of handicap due to tinnitus for both research and clinical use.
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Sublingual Immunotherapy in Asian Children: 2-Year Follow-Up Results
한동열,박일호,신재민,유익원,조정선,이흥만 대한비과학회 2015 Journal of rhinology Vol.22 No.2
Backgrounds: House-dust mites are the main cause of allergic rhinitis in Asia, for which immunotherapy (SLIT) is a currently accepted treatment. However, few studies have evaluated the efficiency of SLIT on Asian children with allergic rhinitis for a period longer than one year. The aim of this study was to investigate the efficacy and safety of SLIT for Asian children with allergic rhinitis due to house-dust mites over a 2-year period. Materials and Method: This study included 65 patients who had allergic rhinitis due to Dermatophagoides pteronyssinus and Dermatophagoides farinae. All patients were treated with SLIT (StaloralⓇ). Symptom scores and quality of life were evaluated by using questionnaires over two years. The medication score was assessed monthly by a diary medication card and serologic tests were evaluated before and two years after the start of treatment. Adverse effects and dropout rates were also investigated. Results: All nasal and non-nasal symptoms and quality of life were significantly improved after two years of treatment. Furthermore, the total medication score decreased significantly and the serologic tests showed a significant change two years after the start of SLIT. Although minor adverse effects were reported, no systemic reactions were observed. The dropout rate was 40%. Conclusion: SLIT is an efficient and safe therapeutic tool for a period of two years in Asian children with allergic rhinitis to house-dust mites.
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조우성(Woo-Sung Cho),김우주(Woo-Joo Kim),유익원(Ik-One Yoo),황호연(Ho-Yeon Hwang),백승국(Seung-Kuk Baek),우정수(Jeong-Soo Woo),권순영(Soon-Young Kwon),정광윤(Kwang-Yoon Jung) 대한두경부종양학회 2007 대한두경부 종양학회지 Vol.23 No.2
Parathyroid gland tumor is an uncommon disease. The symptoms of parathyroid gland tumor appear in various features such as general weakness, renal stones, bone diseases and malignancies in some cases. We summarized the clinical features of 6 cases of parathyroid gland tumors with literatures.
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