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비소세포암에서 C-erbB-2와 COX-2 발현의 면역조직화학적 관련성
유승진 외 중앙대학교 의과대학 의과학연구소 2010 中央醫大誌 Vol.35 No.1/2
Background & Purpose: The study for inhibitors of gene products participating in multistep carcinogenetic event of human cancer is important target relevant to chemoprevention or adjuvant therapy of cancer. This study was performed to search basic data for chemoprevention or adjuvant therapy of human non-small cell lung cancer and to evaluate coexpression of each gene product, the relationship between the expression of each gene product and clinicopathologic factor or prognosis. Method: The following formalin-fixed paraffin embedded surgical specimen was immunohistochemically stained by avidin-biotin complex method for C-erbB-2 and COX-2; 55 cases of squamous cell carcinoma and 29 cases of adenocarcinoma of lung. Results: Positive C-erbB-2 and COX-2 expression is more often seen in adenocarcinoma compared with squamous cell carcinoma. Correlation between early and advanced cancer was insignificant. Coexpression of C-erbB-2 and COX-2 expression is more often seen in adenocarcinoma compared with squamous cell carcinoma. Conclusion: These results suggested that degree of C-erbB-2 and COX-2 expression depended upon histologic type of non-small cell lung cancer. However, further studies are required for the determination of significant relationship in coexpression of two gene products and clinicopathologic indices.
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