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김용기(Yong Kee Kim),남석우(Suk Woo Nam),박승희(Seung Hee Park),유세근(Se Geun Yoo),홍성렬(Sung Youl Hong),이향우(Hyang Woo Lee) 대한약학회 1994 약학회지 Vol.38 No.1
Nitric oxide(NO) synthase was identified and characterized by determining the L-citrulline formed in the NO-Arg pathway in pancreatic tissues. NO synthase activities in chicken pancreas were dependent upon the concentration of L-Arg which is the substrate molecule for the NO synthase, the amount of the enzyme protein used, and linearly on the incubation time. NO synthase in mouse pancreas was found to be constitutive, not induced by lipopolysaccharide treatment. In vitro NO synthase activities of chicken pancreas were inhibited 36%, 21%, 12% and 44% by 200mcM of MMA, DMA, D''MA and NAME respectively. These results suggest the presence of NO and NO synthase in the pancreas.
당뇨병 유발쥐혈청내 methylated amino acid의 함량 변화
김용기,유세근,남석우,이향우 성균관대학교 약학연구소 1993 成均藥硏論文集 Vol.5 No.1
In order to investigate the relationship between methylated amino acids and diabetes, we investigated the changes of serum concentration of methylated amino acids in serum of the experimentally induced diabetic rats. The diabetic symptom was induced by injectly alloxan 100 mg/kg intraperitoneally. The serum content of N^G-monomethylarginine(MMA), N^G, N^G-dimethyl-arginine(DMA) and N^G, N^G-dimethylarginine(D'MA) were analyzed by HPLC. The results are as followings ① There was no change in serum content of MMA in the diabetic group. ② But it was observed that the amounts of DMA and D'MA were increased remarkably in the diabetic group. Specifically, D'MA content was increased about 7 times in comparision to that of the control group. ③ However, the concentration of trimethyllysine in RBC was decreased slightly in diabetic group but not significant statistically.