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유봉규,Yu, Bong G. 한국임상약학회 2001 한국임상약학회지 Vol.11 No.2
Ziprasidone is equally effective as haloperidol in treating schizophrenia with fewer side effects and drug interactions. Ziprasidone is an atypical antipsychotic agent and works by blocking serotonin and dopamine receptors in the central nervous system, specifically 5-HT2A and D2 receptors. Low anticholinergic side-effects and low EPS would recommend the drug for use in the elderly. Ziprasidone inhibits reuptake of norepinephrine and serotonin at neurojunction sites in vitro, indicating a potential efficacy for depression and negative symptoms which often follow after exacerbation of schizophrenia. Patients with recent acute myocardial infarction and uncompensated heart failure are contraindicated to the drug due to a possibility of QT prolongation. Although ziprasidone is metabolized by cytochrome P450 3A4, there is no significant drug interaction with the drugs that induce or inhibit the isoenzyme. Ziprasidone is safe with coadministration of lithium and there has been no significant drug interaction reported with oral birth control pills.
유봉규(Bong G . Yu) 한국약제학회 2001 Journal of Pharmaceutical Investigation Vol.31 No.1
N/A The aggregation behavior of nystatin (NYS) in the presence of pluronic F127, triblock copolymer of poly (ethylene oxide) (PEO) and poly (propylene oxide) (PPO), was measured and correlated with hemolytic activity. Antifungal activity was also studied using Saccharomyces cerevisiae as a model strain. The critical aggregation concentrations (CAC) of the drug were 50.1, 108.0, 134.2, 154.3, and 217.9 μM at 0.1%, 0.5%, 1.0%, 1.5%, and 2.0% pluronic F127 solution, respectively. The levels of NYS required to start lysis of erythrocytes were about 80, 100, 125, 150, and 200 μM at 0.1%, 0.5%, 1.0%, 1.5%, and 2.0% pluronic F127 solution, respectively. It was 50 μM in the absence of the polymer. Minimal inhibitory concentration (MIC) and minimal fungicidal concentration (MFC) of NYS-pluronic F127 lyophilizate were same at 3 ㎍/㎖, while MIC and MFC of pure NYS are 3 ㎍/㎖ and 12 ㎍/㎖, respectively. By modulating the aggregation behavior of NYS, pluronic F127 was able to reduce the toxicity of the drug without compromising the MIC and MFC.
폴리에틸렌 옥사이드가 암포테리신 - B 의 응집 특성 및 독성에 미치는 영향
유봉규(Bong G . Yu) 한국약제학회 2001 Journal of Pharmaceutical Investigation Vol.31 No.1
N/A Amphotericin B (AmB) is a drug of choice for the treatment of systemic fungal diseases, but its use is considerably limited due to a high incidence of toxicity, particularly nephrotoxicity. It has been demonstrated that the toxicity of AmB is caused by self-aggregated species of the drug and that unaggregated (monomeric) drug is nontoxic but still expresses antifungal activity. Poly (ethylene oxide) (PEO) is a water-soluble polymer, which may impact the aggregation state of AmB. We have studied the aggregation state of AmB as a function of PEO molecular weight and concentration. At 3,000 and 8,000 g/mole, there was minimal or no change of critical aggregation concentration (CAC) of AmB regardless of the concentration of polymer. By contrast at 20,000 g/mole, the CAC of AmB strikingly increased to 24.3 and 37.5 μM at 5.0% and 10% w/v of polymer, respectively. The critical overlap concentration (COC) of PEO 20,000 g/mole was 5.5%. It appears that an interaction between monomeric AmB and polymer coil increases above the COC, competing with self-aggregation of the drug. Accordingly, the degree of aggregation of AmB stayed low and the toxicity became less. There was no such effect at 3,000 and 8,000 g/mole of PEO, owing perhaps to small dimensions in comparison to AmB. Based upon these findings, less toxic AmB formulation may be developed by a pharmaceutical technique such as solid dispersion system containing both AmB and PEO 20,000 g/mole.
연구논문 : 생명과학 ; 인간에서의 경구흡수를 촉진하는 투명 아세클로페낙 연질캅셀의 개발
용철순 ( Chul Soon Yong ),오유경 ( Yu Kyoung Oh ),이경희 ( Kyung Hee Lee ),박상만 ( Sang Man Park ),길영식 ( Young Sig Gil ),유창훈 ( Chang Hun Yu ),김종오 ( Jong Oh Kim ),유봉규 ( Bong Kyu Yoo ),이종달 ( Jong Dal Rhee ),김종국 ( 영남대학교 약품개발연구소 2005 영남대학교 약품개발연구소 연구업적집 Vol.15 No.-
관절염 치료 보조제로서 커큐민의 유효성 및 안전성에 대한 문헌고찰
심민지(Min Ji Sim),이은아(Eun Ah Lee),이인애(In Ae Lee),정수진(Soo Jin Jeong),조유진(Yu Jin Jo),유봉규(Bong Kyu Yoo) 대한약학회 2017 약학회지 Vol.61 No.6
Curcumin has excellent antioxidant and anti-inflammatory properties and is used for the prevention and treatment of various diseases. It has recently been developed as a health supplement and widely available worldwide. In particular, curcumin-containing preparations are used as health-functional foods for arthritis patients and semi-healthy persons, but detailed clinical data related to them are not well-recognized in Korea. In this article, data on the safety and efficacy of curcumin for joint and bone health-related efficacy were collected via Pubmed and Clinical Trials.gov databases, which are administered by the US National Library of Medicine. A total of 126 articles were searched in the Pubmed and Clinicaltrials. gov databases. Four records of the articles were clinically related with knee osteoarthritis. Three of the four clinical trials collected were phase 2 studies with a prospective randomized double-blind placebo-controlled trial, and one phase 3 study with a prospective randomized double-blind, active, comparator trial. Analysis of these four clinical trial data showed that introduction of curcumin as a preventive and therapeutic adjunct to osteoarthritis could be a treatment alternative for osteoarthritis patients. However, the clinical data published so far have not been enough to show the validity of the results. Therefore, a broader clinical trial for the efficacy and safety of curcumin as an adjuvant for treating osteoarthritis is warranted.
연구논문 : 생명과학 ; 퀴니졸리노카볼린 앙카로이드계인 루테칼핀의 일반신경약리에 관한 연구
장종선 ( Jong Sun Chang ),김대경 ( Da Qing Jin ),박병철 ( Byung Chul Park ),장영동 ( Yurng Dong Jahng ),유봉규 ( Bong Kyu Yu ),최한곤 ( Han Gon Choi ),용철순 ( Chul Soon Yong ),정태천 ( Tae Cheon Jeong ),김정애 ( Jung Ae Kim ) 영남대학교 약품개발연구소 2005 영남대학교 약품개발연구소 연구업적집 Vol.15 No.-