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      • KCI등재

        Comparison of the Effectiveness of Monitoring Cisplatin-Induced Ototoxicity with Extended High-Frequency Pure-Tone Audiometry or Distortion-Product Otoacoustic Emission

        유광규,최치호,안용휘,곽민영,공수정,윤상원,심현준 대한청각학회 2014 Journal of Audiology & Otology Vol.18 No.2

        Background and Objectives: To compare the effectiveness of monitoring cisplatin-induced ototoxicity in adult patients using extended high-frequency pure-tone audiometry (EHF-PTA) or distortion-product otoacoustic emission (DP-OAE) and to evaluate the concurrence of ototoxicity and nephrotoxicity in cisplatin-treated patients. Subjects and Methods: EHF-PTA was measured at frequencies of 0.25, 0.5, 1, 2, 3, 4, 6, 8, 9, 11.2, 12.5, 14, 16, 18, and 20 kHz and DP-OAE at frequencies of 0.5, 0.75, 1, 1.5, 2, 3, 4, 6, and 8 kHz in cisplatin-treated patients (n=10). Baseline evaluations were made immediately before chemotherapy and additional tests were performed before each of six cycles of cisplatin treatment. Laboratory tests to monitor nephrotoxicity were included before every cycle of chemotherapy. Results: Four of 10 patients showed threshold changes on EHF-PTA. Five of 10 patients showed reductions in DP-OAE, but one was a false-positive result. The results of EHF-PTA and DP-OAE were consistent in two patients. Only one patient displayed nephrotoxicity on laboratory tests after the third cycle. Conclusions: In our study, the incidence rate of cisplatin-induced ototoxicity was 40% with EHF-PTA or DP-OAE. Although both EHF-PTA and DP-OAE showed the same sensitivity in detecting ototoxicity, they did not produce the same results in all patients. These two hearing tests could be used to complement one another. Clinicians should use both tests simultaneously in every cycle of chemotherapy to ensure the detection of ototoxicity

      • KCI등재후보

        골도 및 기도 자극에 의한 경부 전정유발 근전위의 비교

        강현우,유광규,곽민영,진소영,윤상원,심현준,안용휘 대한이비인후과학회 부산,울산,경남 지부회 2013 임상이비인후과 Vol.24 No.2

        Backgrounds and Objectives:The aim of this study was to investigate the incidence of cervical vestibular-evoked myogenic potentials (cVEMP) responses induced by bone-conduction (BC) stimulation and to compare the characteristics of parameters of cVEMP using BC and air-conduction (AC) sounds in normal volunteers. Materials and Methods:Thirty seven normal subjects (74 ears) with normal hearing and no previous history of dizziness were included. cVEMP responses were recorded by surface electrodes on sternocleidomastiod muscles in response to AC and BC stimuli sequentially. Variances of parameters, including latencies, amplitudes, inter-latencies difference and inter-aural amplitude asymmetry, were analyzed and compared. Results:Responses of cVEMP by AC sounds were clearly observed in all 74 ears whereas those by BC sounds were detected in 41 ears (55.4%). There was no significant difference in latencies and inter-latencies intervals. Inter-aural amplitude asymmetry ratios showed no significant difference between the two tests, although amplitudes in BC-cVEMP testing were significantly smaller than those in AC-cVEMP testing. Conclusions:BC-cVEMP requires cautions in clinical application as compared with AC-cVEMP. An effective bone vibrator or high-intensity stimulation is needed to produce more reliable responses of BC-cVEMP

      • KCI등재

        어지럼증이 동반되지 않은 급성 저주파 감각신경성 난청의 고실 내 스테로이드 및 경구 이뇨제 병용 요법

        곽민영,유광규,강용경,윤상원,심현준,안용휘 대한이비인후과학회 2015 대한이비인후과학회지 두경부외과학 Vol.58 No.1

        Background and Objectives The effectiveness of intratympanic dexamethasone injections (ITD) alone is compared against the combination therapy of ITD and oral diuretics as treatments for acute low frequency sensorineural hearing loss (LFHL) without vertigo. Subjects and Method A total of 36 patients, with LFHL ≤500 Hz that had been developed within the last 1 month, were enrolled and then were retrospectively categorized into two groups: 1) those treated with ITD four times each day for 4 consecutive days (ITD only group; 19 patients) and 2) those treated with ITD in the same way and diuretics orally for 2 weeks (combination group; 17 patients). After 8 weeks, treatment outcomes were analyzed for LFHL using subjective improvement and audiometric change. Results Hearing thresholds at low frequencies ≤500 Hz were significantly reduced at 8 weeks after treatment in both ITD only and combination group (p<0.05). The cure rate of the combination group was higher than that of the ITD only group but was not statistically significant (52.9% vs. 42.1%, p>0.05). For subjective symptoms, there were no statistically significant differences in the improvement rate in either group (combination 58.8% vs. ITD only 63.2%, p>0.05). In pure tone audiometry, the improvement rate of the combination group was not significantly different from that of the ITD only group (76.5% vs. 73.7%, p>0.05). There was a significant correlation between the complete recovery rate and duration of symptoms. Conclusion ITD alone is an effective treatment modality for LFHL within 1 month after onset. Diuretics have no additive effect for the recovery of hearing in patients with acute LFHL without vertigo.

      • KCI등재후보

        인후두역류증이 의심되는 환자에서 비디오투시법의 역할

        이승주,유광규,곽민영 대한이비인후과학회 부산,울산,경남 지부회 2014 임상이비인후과 Vol.25 No.2

        Backgrounds and Objectives:The aim of this study was to investigate the value of videofluoroscopy (VF) inpatients with laryngopharyngeal reflux (LPR) suspected on the basis of reflux symptom index (RSI) and refluxfinding score (RFS). Materials and Methods:The patients with RSI >13 and RFS >7 were enrolled. The VFwas conducted in all patients, who were divided into the reflux and the no reflux group. Proton pump inhibitor(PPI) was prescribed to all patients for more than 8 weeks. Results:Sixty-six patients were followed for 8 weeks. On VF, 32 patients (48.5%) had reflux and 34 patients had no reflux. The two groups showed no significant differ -ences in demographic data, baseline characteristics, the mean changes in RSI and RFS after treatment. There wasno correlation between the presence or absence of reflux and the effectiveness of PPI treatment. Conclusions:Among our patient population, a subgroup including about half of the patients was found to have reflux on VF. Therefore, at least in this subgroup, VF may have a role to support the diagnosis of the patients with suspectedLPR.

      • KCI등재

        한국인의 특성에 맞춘 매부리코의 교정

        김지선,유광규 대한이비인후과학회 2014 대한이비인후과학회지 두경부외과학 Vol.57 No.12

        The Korean hump nose often differs from Caucasian hump nose in that the size of the nasal hump is not prominent and the hump is frequently associated with a low nasal dorsum and radix with under-projected nasal tip. Therefore, typical reductive rhinoplasty techniques are not effective in managing the characteristic anatomy of the Korean hump nose. Because Korean hump nose patients have all kinds of nasal deformity including low dorsal profile, abnormal tip projection, tip rotation and deviation, surgeons should be skilled at various techniques of rhinoplasty. Removal of hump should be performed gradually considering the balance of nasal tip and nasal dorsum and radix. Small hump with low radix can be corrected by radix augmentation. If the hump is big, the hump should not be remained by too conservative removal of the hump. Most hump in Korean nose may be corrected well by using nasal tip and dorsal augmentation with the appropriate hump removal. The strengthening and augmentation of nasal structure using autologous cartilage may accomplish the balanced correction of hump nose aesthetically and functionally with tailored removal of hump in Korean patients. Korean J Otorhinolaryngol-Head Neck Surg 2014;57(12):815-20

      • KCI등재

        Frontoethmoidal Cells on Computed Tomographic Analysis: The Prevalence and Relationship to Frontal Sinus/Recess Mucosal Thickening

        이승주,강현우,유광규 대한비과학회 2014 Journal of rhinology Vol.21 No.1

        Objectives : To determine the prevalence of frontoethmoidal cells (FECs) in patients with and without frontal sinus/recess mucosal thickening and to establish the relationship between the FECs and the frontal sinus/recess mucosal thickening. Materials and Methods : We retrospectively reviewed 245 consecutive ostiomeatal CT scans (490 sides). The normal and frontal sinus/recess mucosal thickening groups were categorized based on these images. The latter group was sub-categorized into the frontal sinus mucosal thickening group (FS group) and the frontal recess mucosal thickening group (FR group). Results : Types 1, 2, 3 and 4 frontal cells were found in 17.5, 6.7, 8.3 and 0%of 326 normal sides, respectively. The prevalence of agger nasi, suprabullar, frontal bullar,supraorbital ethmoid and interfrontal sinus septal cells was 85.6, 43.3, 4.9, 4.3 and 17.2% of the same 326 normal sides, respectively. Type 3 frontal cells, frontal bullar cells and suprabullar cells were more prevalent in the FS and FR groups than in the normal group. All types of cells were more prevalent in the FS group, but only the suprabullar cells were more prevalent in the FR group than in the normal group. Conclusion : These findings suggest that type 3 frontal cells, frontal bullar cells and suprabullar cells may have a significant association with frontal sinus/recess mucosal thickening.

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