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원태혁,이동초,오경재 원광대학교 대학원 2008 論文集 Vol.40 No.-
The palmoplantar keratoses comprise a heterogenous group of disorders of keratinization, which can be subdivided into hereditary and acquired forms. Epidermolytic palmoplantar keratoderma (EPPK) is an autosomal dominant disease which presents as abnormal thickening of the palms and soles with epidermolytic hyperkeratosis pathologically. We report a 18-month-old female baby showing the clinical and histologic features of EPPK without family history. She has been treated intermittently with topical urea and oral isotretinoin for 2 years, but the lesions remain unchanged.
원태혁,김보석,서필승,박석돈 圓光大學校 醫科學硏究所 2008 圓光醫科學 Vol.23 No.2
Familial benign chronic pemphigus is a rare autosomal dominant disease characterized by recurrent vesicobullae on intertriginous areas. It's very hard to treat, so there's many kind of treatment such as steroid, antibiotics, retinoid, operation, phototherapy, laser ablation. We report 2 cases of familial benign chronic pemphigus that showed good improvement with treatment of antibiotics
원태혁 ( Tai Hyok Won ),서필승 ( Phil Seung Seo ),박석돈 ( Seok Don Park ) 대한피부과학회 2009 大韓皮膚科學會誌 Vol.47 No.3
Background: Exposure to Rhus (Japanese lacquer) can cause many adverse effects such as contact dermatitis, pruritus, rash and even hepatitis in human, and these effects can be caused by contact or ingestion of Japanese lacquer. Many Koreans currently eat Japanese lacquer boiled with chicken although it has many side effects. Koreans believe that Rhus will improve their health. However, they don`t known its adverse effects, and there is no experimental report on this topic. Objective: The principle objective of this study was to gather evidence on the toxicity and negative effects of Japanese lacquer through an experimental study with rats. Methods: A total of 60 Sprague-Dawley rats were included in the study; 30 rats (experimental group) were given 0.1 ml of Japanese lacquer sap extract, water and food, and 30 rats (control group) were given only food and water. The WBC, the Hgb, ALT, AST, BUN and creatinine levels, the presence of pruritis and skin eruption, the skin biopsy findings and the liver biopsy findings were all checked at 5, 10, and 15 days. Results: The rats that were given Japanese lacquer sap showed a higher WBC and higher ALT and AST levels and only these rats demonstrated erythroderma (5th day: 30%, 10th day: 40%, 15th day: 70%). In addition, they exhibited frequently scratching behavior. On histological examination of the skin of the rats given Rhus, dermal edema and mild inflammatory cell infiltration were found. On histological examination of the liver of the rats given Rhus, there was no significant change as compared with the rats that weren`t given lacquer. Conclusion: In this experimental study, it was proven that Rhus could induce pruritis, erythroderma, skin inflammation and hepatotoxicity. (Korean J Dermatol 2009;47(3):251∼258)