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우영균(Young Kyun Woo),최석원(Suck Won Choi),박기화(Ki Hwa Park) 대한자원환경지질학회 1991 자원환경지질 Vol.24 No.4
Field and microscopic evidence, XRD, EPMA and chemical data suggest that parent rock of talc ore deposits of Yesan district was originated from ultramafic igneous rock. Parent rock can be divided into serpentinized dunite, serpentinized peridotite, metagabbro, amphibolite and hornblende schist. The ore deposits are highly sheared, and show many evidences of hydrothermal alteration and metamorphism at the greenschist and albite-epidote amphibolite facies. The process of steatitization is variable depending upon the composition, and the degree of alteration and metamorphism of the parent rocks. Steatitization can be divided into two processes with or without serpentinization. The parent rocks with serpentinization are serpentinized dunite, serpentinized peridotite and metagabbro, showing the following alteration process; olivine→serpentine→talc. The rocks without serpentinization are amphibolite and hornblende schist showing the following sequence; hornblende→chlorite→talc. Formation of talc deposits is summarized as following six stages; 1) Intrusion of ultramafic rocks, 2) autometamorphism, 3) metamorphism at greenschist and albite-epidote-amphibolite facies, 4) brittle deformation, 5) hydrothermal alteration, 6) purification of low-grade talc by late dyke intrusion.
슬관절 전방십자인대 신연 손상에 따른 기질 금속 단백 분해 효소(MMP)-2의 발현
우영균(Young Kyun Woo),송석환(Seok Whan Song),권순용(Soon Yong Kwon),이화성(Hwa Sung Lee),김영훈(Young Hoon Kim) 대한정형외과학회 2006 대한정형외과학회지 Vol.41 No.4
목적: 조직 재형성 과정은 손상된 조직의 자연 치유에 필수적이다. 세포외 기질 분해에 관여하는 기질 금속단백 분해효소(matrix metalloproteinase, MMP)가 이 과정에서 중요한 역할을 하는데, 본 연구는 전방십자인대의 손상에 따른 MMP-2의 발현을 알아보고자 하였다. 재료 및 방법: MMP-2의 지속적인 발현 여부를 파악하기 위해 쥐에서 대퇴골-전방십자인대-경골 복합체를 얻어 신연 손상을 가한 후 1주일간 관찰하였다. 그 후 인대 복합체를 세 군으로 나누어, 제1군은 5 N 및 12 N으로 10, 30, 60분 동안, 제2군은 5와 15 N의 힘으로 5, 10, 30, 60 및 120분 동안, 제3군에서는 5, 8, 10, 12 및 15 N 하에 각각 30 및 60분 동안 손상을 주었다. MMP-2의 발현은 0.05% gelatine zymography를 이용하여 검사하였다. 결과: 인대 손상 후 MMP-2의 지속적인 분비를 관찰할 수 있었으며, 발현 강도는 손상 받은 시간이나 가해진 힘의 크기에 비례하여 증가하였다. 인대 조직 자체의 검사에서는 배양액의 결과보다 전구형의 발현 강도는 미약했으나, 활성형은 더욱 뚜렷이 나타났으며, 손상 시간 및 크기에 따라 발현 정도는 역시 증가하였다. 결론: MMP-2는 인대 손상 후에 즉각적으로 발현되었으며, 강도는 손상 시간이나 가해진 힘에 비례하여 증가하였다. MMP-2의 발현이 인대 손상 후 진행되는 조직 재형성기 과정에서 중요한 역할을 할 것으로 생각된다. Purpose : Tissue remodeling is essential for the natural healing of damaged tissue. The matrix metalloproteinases (MMPs) that degrade the extracellular matrix to play a central role in this process. This study was designed to examine the basic relationship between MMP-2 and anterior cruciate ligament (ACL) injury. Materials and Methods : After the femur-ACL-tibia complex was harvested from rats, the continuous release of MMP-2 in the stretch group was evaluated. The complexes were divided into three groups. To stretch the complexes, in group I, 5 and 12 N weights were used for 10, 30, and 60 minutes. In group Ⅱ, 5 and 15 N weights were used for 5, 10, 30, 60, and 120 minutes. And in group Ⅲ, 5, 8, 10, 12, and 15 N weights were used for 30 and 60 minutes. MMP-2 activity was evaluated using 0.05% gelatin zymography. Results : MMP-2 was expressed and the signal intensity was increased according to the stretch duration and magnitude. In the tissue analysis, active MMP-2 was markedly present and the expression was increased in response to the stretch in the supernatant samples. Conclusion : MMP-2 was released immediately after ligament injury and its activity was increased in proportion to the stretch duration and magnitude. It is believed that MMP-2 expression plays an important role in the remodeling process after an ACL injury.
우영균(Young Kyun Woo),이화성(Hwa Sung Lee),김주영(Ju Young Kim) 대한정형외과학회 2006 대한정형외과학회지 Vol.41 No.4
목적: 슬관절 전치환술 시 슬개골 치환 유무에 따른 임상적, 방사선학적 결과를 비교하여 효용성 여부를 알고자하였다. 대상 및 방법: 2002년 1월부터 2003년 6월까지 양측 슬관절 치환술을 동시에 시행한 환자들 중 무작위로 한측만 슬개골 치환술을 시행한 환자 20명을 대상으로 전방 슬관절 통증의 유무와 knee society clinical rating system, patellar score, patient-satisfaction score, 슬개-대퇴 관절 일치성(patellofemoral congruency)을 조사하였다. 결과: 전체적인 knee society knee score나 patellar score에서 슬개골 치환술을 시행한 군과 하지 않은 군 사이에 통계적으로 의미 있는 차이는 없었으며, patient-satisfaction score에서도 술 후 전방 슬관절 통증이 있던 4예 중 2예서만이 불만족스러운 결과를 보였고, 슬개-대퇴 관절 일치성에서는 슬개골 비치환군과 치환군에서 각각 98.8%, 98%의 일치성을 보였다. 결론: 슬관절 전치환술 시 슬개골 치환 여부가 임상적, 방사선학적으로 결과에 영향을 미치지 않았으며, 수술전 관찰되는 전방 슬관절 통증이나 슬개골 병적 상태, 슬개골 정렬 상황, 수술 기법 등을 고려하여 판단해야 할 것으로 생각된다. Purpose : This study evaluated the clinical and radiological results of a randomized clinical trial of patella resurfacing. Materials and Methods : A blinded, prospective study was carried out for 20 patients who underwent bilateral TKA with one patellar side being resurfaced from Jan. 2002 to Jun. 2003. The clinical results were assessed using the knee society clinical rating system, patellar score and patient-satisfaction score. Radiologically, patellofemoral congruency was assessed by measuring the patellar displacement in the skyline view. Results : There were no significant differences between the resurfaced and non-resurfaced knees with respect to the overall knee society knee scores or the patellar scores. In the patient-satisfaction scale, 2 out of 4 knees with anterior pain postoperatively were unsatisfactory to the patients. The average patellar congruency in the non-resurfacing/resurfacing group was 98.8%/98%. Conclusion : The clinical and radiological results after TKA were not associated with patellar resurfacing. It appears that a variety of factors such as preoperative anterior knee pain, pathological lesion and alignment of patella, and the surgical technique are related to the postoperative results.
우영균 ( Young Kyun Woo ),장주해 ( Ju Hai Chang ),김용식 ( Yong Sik Kim ),권순용 ( Soon Yong Kwon ),김기원 ( Ki Won Kim ),김양수 ( Yang Soo Kim ) 대한고관절학회 1995 Hip and Pelvis Vol.7 No.1
We took a retrospective assessment about the relationships to steroid therapy with 12 patients of AVN in SLE, comparing with the control cases which were composed of 25 patients of SLE followed up more than 5 years but free from evidence of AVN, who had been treated at Catholic University Medical College from 1986 to 1992. Based on results of above assessment, we carried out comparative analysis of above 2 groups to delineate the statistical significance between AVN and steroid therapy in SLE using Student's t-test, and its each items of statistical analysis were as follows; initial cumulative dosage on 1, 3, 6 months, average monthly dosage, average monthly dosage of pulse therapy and average monthly dosage of maintenance therapy throughout follow up period. In addition, we also reported the author's clinical experience in the orthopaedic management of 12 AVN patients in SLE with a respect of age & sex distribution, interval between diagnosis of SLE and AVN, involvement sites, radiologic stage especially in femoral head, treatment method and complication of treatment. This retrospective study was relatively fragmentary but shows that both initial higher steroid therapy and average dosage per months seem to be related with eventual development of AVN in SLE. In addition, the average monthly dosage of pulse therapy seems to have an influence on development of AVN in SLE also. But, the more distinct cause of AVN and the role of steroid in SLE may be elucidated through the further prospective attempt with an elaborate plan in concert with medical doctors.