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비부 기저세포암의 모즈 수술후 bilobed flap 을 이용한 재건술
오창근(Chang Keun Oh),장봉석(Bong Seok Jang),김문범(Moon Bum Kim),장호선(Ho Sun Jang),권경술(Kyung Sool Kwon) 대한피부과학회 2002 大韓皮膚科學會誌 Vol.40 No.9
N/A Background: The skin over the lower one third of the nose is less mobile and cannot be easily recruited for the closure of even small defects. In addition, the texture and color of the nose are so unique that neither distant nor nearby skin can always provide a good match, Therefore, when we reconstruct the surgical defect of lower one third of the nose, we must consider the reconstruction method, defect site or size, recurrence of the lesion such as basal ce11 carcinoma, patient age, general health state, and functional and cosmetic aspects. The bilobed flap is a useful tool for reconstruction of the nose but is occasionally complicated by pincushioning effect ax trapdoor deformity. Objective: The pro of this study was to evaluate the usefulness of a geometric design of bilobed flap for use in reconstructing defect on the lower one third of the nose. Methods: From February 1999 to March 2001, we reconstructed defects on the lower one third of the nose after Mohs surgery of basal cell carcinoma in 6 patients using the geometrical design of bilobed flap. Patients were reviewed for complications and cosmetic results. Results: Cosmetically acceptable results were seen in all patients. Significant pincushioning and trapdoor deformity were not presented postoperatively in any patients. Conclusion: The geometrical design of bilobed flap is an excellent choice for reconstruction of defects of the lower one third of the nose, particularly around the nasal tip, because of the good skin match and low incidence of complication, (Korean J Dermatol 2002;40(9) : 1064~1069)
Becker ` s Melanosis의 임상 및 병리조직학적 관찰
오창근(Chang Keun Oh),정태안(Tae Ahn Chung),하은희(Eul Hee Ha) 대한피부과학회 1994 大韓皮膚科學會誌 Vol.32 No.1
Background : Beckers melanosis is not an uncommon entity, and niany cases are probably not reported because the diagnosis is usually made clinically and the conditioii is benign with cosmetic significance only. The etiology remains obscure. Objective : Th
오창근(Chang Keun Oh),장봉석(Bong Seok Jang),김문범(Moon Bum Kim),권경술(Kyung Sool Kwon) 대한피부과학회 2002 대한피부과학회지 Vol.40 No.8
Large surgical defects of the face can often be difficult to repair. And so, extersive adjacent tissue transfer may be necessary and may result in significant scars and possible flap compromise. Often there may be less donor tissue available than is necessary to achieve closure. Four cases of malignant tumors on the face were removed by Mohs micrographic surgery, followed by reconstruction of large defects utilizing a purse-string suture and a full-thickness graft. This method enabled dermatologist to reconstruct large surgical defects of the face with a relatively small full-thickness graft. In our cases, there were no significant complications and the results were cosmetically acceptable.
흉골늑골쇄골간 과골증을 동반한 수장 족저 농포증 ( 농포성 관절골염 ) 3예
오창근(Chang Keun Oh),최석주(Suk Joo Choi),문두찬(Doo Chan Moon),권경술(Kyung Sool Kwon),정태안(Tae Ahn Chung) 대한피부과학회 1992 대한피부과학회지 Vol.30 No.5
Pustulotic arthro-osteitis is a rheumatic syndrome of unknovn cause, characterised by an inflammatory osteitis of the sternocostoclavicular region and pustuosis palmaris et plantaris. Although many ases of the disease have been reported in Japan, it, has not been reported in Korea so far. Three cases of pustulosis palmaris et plantaris associated i rith sternocostoclavicular hyperostosis or pustulotic arthro-osteitis are presented. (Kor J Dermatol 1992;30(5l:693-700)
한국인의 기저세포암에서 p53 유전자 돌연변이에 대한 분석
오창근(Chang Keun Oh),이준호(Jun Ho Lee),임재영(Jae Young Lim),김성준(Sung Jun Kim),김문범(Moon Bum Kim),장호선(Ho Sun Jang),권경술(Kyung Sool Kwon) 대한피부과학회 2002 대한피부과학회지 Vol.40 No.6
N/A Background : There were few data on the gend mutations involved in the development of basal cell carcinoma(BCC) in Korean. Objective : To gain insight into the role of p53 gene mutations of BCC in Koreans. Methods : Fifteen BCCs were screened for mutation of the p53 gene. Immunohistochemical staining was done on the paraffin sections using a labelled streptavidin-biotin-peroxidase complex method with the primary antibody against p53 protein. Analysis of p53 mutation was done by non-isotopic RNase cleavage assay and direct sequencing. Results : Mutation of p53 gene was found in 40%(6/15) of the cases, One case showed mutations in exon 6, one exon 6 and intron 8, two in exon 8, one in exon 9, and one in intron 5. But ultraviolet specific C-T change was detected in only one case, Immunohistochemical expression of p53 was seen in 40%(6/15). but its expression did not coincide with p53 gene mutation. Conclusion : Ultraviolet specific mutations of p53 were much less frequent in Korean than in Caucasian, suggesting other etiologies than ultraviolet radiation.