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감태(甘苔)에서 추출한 Dieckol 성분이 쥐의 인지능력에 미치는 영향
오재근 ( Jae Keun Oh ),송기재 ( Ki Jae Song ),지무엽 ( Mu Yeop Ji ),윤진호 ( Jin Ho Yoon ) 대한본초학회 2014 大韓本草學會誌 Vol.29 No.6
Objectives : The purpose of this study aimed to investigate that dieckol - isolated from Ecklonia cava - supplementation can improve cognitive ability in mice. Methods : 48-male mice(6 weeks old) were divided into four groups; High-Dieckol group(n=12), Low-Dieckol group(n=12), Placebo group(n=12), Control group(n=12) and they were administered orally 5 days per week for 4 weeks at the same time. We performed Morris water maze test, Passive avoidance test, Blood serotonin analysis. And there was examined on neurogenesis in dentate gyrus of hippocampus using 5-bromo-2`-deoxyuridine (BrdU) to label proliferating cells. Results : The results are as follows; As a Morris water maze results, Trial duration was significantly decreased in high dieckol group comparing to placebo group and control group. Distance to target was significantly decreased in high dieckol group and low dieckol group comparing to placebo group and control group. Mean speed was significantly low in high dieckol group comparing to low dieckol group, placebo group and control group. As a Passive avoidance test results, latency time was significantly long in high dieckol group comparing to low dieckol group, placebo group and control group. BrdU cell count was significantly high in high dieckol group comparing to low dieckol group, placebo group and control group. Conclusions : As a conclusion, it is considered that dieckol supplementation might improve learning and cognitive ability.
오재근 ( Jae-keun Oh ),강성우 ( Sung-woo Kang ),박순철 ( Shun-zhe Piao ) 한국체육대학교 체육과학연구소 2016 스포츠사이언스 Vol.33 No.2
본 연구는 관절의 온도 변화가 관절의 고유수용성감각 수용기에 미치는 영향을 알아보고, 올바른 냉처치와 온열처치방법을 위한 기초자료를 제시하는데 그 목적이 있다. 연구대상자는 신체가 건강한 남자16명(24.43±3.11 yr, 172.26±5.13 cm, 68.86±7.36 kg, 14.80±4.52 %BF)을 무작위로 선정하였다. 냉처치는 1kg의 부서진 아이스를 이용한 아이스 팩(ice pack), 온열처치는 핫 팩(hot pack)을 이용하여 각각 슬관절에 15분간 처치하였다. 슬관절 능동ㆍ수동적 고유수용성감각 기능 측정은 등속성 장비 CSMi(HUMAC, U.S.A)를 이용하였고, 가동범위는 0°~90°로 설정하였으며, 목표 각 45°와 15°에서 5초 동안 움직임을 정지시켜 피험자에게 목표 각을 인지시킨 후 재현하도록 하였다. 정적균형 측정은 눈감고 외발서기로 측정하였으며, 동적균형 측정은 Biodex Balance System(Biodex, U.S.A)를 이용하여 외발서기로 Stage-12, Stage-6, Stage-1 세 단계로 나누어 측정하였다. 처치방법에 따른 차이를 비교하기 위해 반복측정 변량분석(repeated measure ANOVA)을 실시하였으며, 모든 통계적 유의 수준은 α=.05로 설정하였다. Stage-1 종합균형능력에서 온열처치(3.88±2.03)가 무처치(5.28±3.06)에 비해 유의하게 낮은 것으로 나타났다(p<.05). Stage-1 전ㆍ후 균형능력에서 냉처치(3.05±1.52)와 온열처치(2.71±1.43)가각각 무처치(4.23±2.52) 보다 유의하게 낮은 것으로 나타났다(p<.05, p<.01). Stage-1 내ㆍ외측 균형능력에서 냉처치(2.32 ±1.09)와 온열처치(2.26±1.22)가 각각 무처치(2.92±1.48) 보다 유의하게 낮은 것으로 나타났다(p<.05, p<.05). 이상의 결과로 볼 때 냉처치와 온열처치는 고유수용성감각 수용기에 영향을 미치는 것으로 사료되며, 향후 보다 많은 피험자들을 대상을 추가적인 연구를 하여 냉처치와 온열처치가 고유수용성감각에 미치는 영향을 조사해야 할 것으로 사료된다. The purpose of this study is to investigate the effects of joint temperature change to the proprioceptive capabilities and to provide the baseline data for cro-therapy and thermo therapy. 16 healthy males were randomly selected (24.43±3.11 yr, 172.26±5.13 cm, 68.86±7.36 kg, 14.80±4.52 %BF). Cryotherapy with 1kg of broken ice bag, thermotherapy with hot pack to knee joint applied for 15 minutes respectively. Knee joint active and passive proprioceptive sensory measurement was performed using an isokinetic equipment CSMi (HUMAC , USA) , the movable range was set to 0° ~ 90° , the target to stop the movement for 5 second s at each 45° and 15° to recognize the subject to reproduce after each goal . Static balance measurements were measured with eyes closed and one leg standing , dynamic balance measurement was measured with Biodex Balance System (Biodex, U.S.A) by dividing the Stage-12, Stage-6, Stage-1 in three steps. All data of this research were analyzed by SPSS/PC ver 21.0 and. repeated measure ANOVA was used to compare the difference between the treatment methods. Post-hoc was conducted by LSD the significance level score was set as α=.05. The results through this process are as followed. Stage-1 overall stability in thermotherapy(3.88±2.03) was significantly lower than in no therapy(5.28±3.06)(p<.05). Stage-1 anterior and posterior stability in cryotherapy(3.05±1.52) and thermotherapy(2.71±1.43) were significantly lower than in no therapy(4.23±2.52)(p<.05, p<.01). Stage-1 medial and lateral stability in cryotherapy(2.32±1.09) and thermotherapy(2.26±1.22) were significantly lower than in no therapy(2.92±1.48)(p<.05, p<.05). According to the result of this study, cryotherapy and thermotherapy are considered to affect the proprioceptive sense. In the future study, experiments against additional number of subjects required to be conducted to ensure the effects of cryotherapy and thermotherapy.