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Ginseonside Rb2 가 노화촉진마우스 ( SAM - R / 1 ) 의 항산화물질에 미치는 영향
오미현,정해영,양한석,김규원,정한영,오우라히코끼치,요꼬자와다까꼬 ( Mi Hyune Oh,Hae Young Chung,Han Suk Yong,Kyu Won Kim,Han Young Chung,Hikokichi Oura,Takako Yokozawa ) 생화학분자생물학회 1992 BMB Reports Vol.25 No.5
During aging, its chance of tissue damage by active oxygen species increases, which causes the abnormal aging as well as diseases like cancer. In biological system, there are enzymes such as superoxide dismutase, catalase and glutathione peroxidase which scavenge active oxygen species as well as antioxidant agents such as ceruloplasmin, albumin and nonprotein-bound SH including glutathione related to defense mechanism. In this study, superoxide dismutase, catalase, serum albumin, protein-bound SH and nonprotein-bound SH levels were increased in SAM-R/1 mice treated with 2.5 or 5.0 ㎎/㎏ ginsenoside Rb₂. But malondialdehyde which is the product of lipid peroxidation was significantly decreased. These results suggest that increase of antioxidants by ginsenoside Rb₂ results in the protective effects against active oxygen species.