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Anti-proliferative Activity of T-bet
오연지,신지현,원희연,황은숙 대한면역학회 2015 Immune Network Vol.15 No.4
T-bet is a critical transcription factor that regulates differentiation of Th1 cells from CD4+ precursor cells. Since T-bet directly binds to the promoter of the IFN-γ gene and activates its transcription, T-bet deficiency impairs IFN-γ production in Th1 cells. Interestingly, T-bet-deficient Th cells also display substantially augmented the production of IL-2, a T cell growth factor. Exogenous expression of T-bet in T-bet deficient Th cells rescued the IFN-γ production and suppressed IL-2 expression. IFN-γ and IL-2 reciprocally regulate Th cell proliferation following TCR stimulation. Therefore, we examined the effect of T-bet on Th cell proliferation and found that T-bet deficiency significantly enhanced Th cell proliferation under non-skewing, Th1-skewing, and Th2-skewing conditions. By using IFN-γ-null mice to eliminate the anti-proliferative effect of IFN-γ, T-bet deficiency still enhanced Th cell proliferation under both Th1- and Th2-skewing conditions. Since the anti-proliferative activity of T-bet may be influenced by IL-2 suppression in Th cells, we examined whether T-bet modulates IL-2-independent cell proliferation in a non-T cell population. We demonstrated that T-bet expression induced by ecdysone treatment in human embryonic kidney (HEK) cells increased IFN-γ promoter activity in a dose dependent manner, and sustained T-bet expression considerably decreased cell proliferation in HEK cells. Although the molecular mechanisms underlying anti-proliferative activity of T-bet remain to be elucidated, T-bet may directly suppress cell proliferation in an IFN-γ- or an IL-2-independent manner.
도전재 종류에 따른 리튬이차전지 음극재 SiOx의 전기화학적 특성
연지수,장보윤,김성수,김향연 한국전기전자재료학회 2019 전기전자재료학회논문지 Vol.32 No.3
This work investigated the effects of different conductive agents on the electrochemical properties of anodes. SiOx possesses high theoretical capacity and shows excellent cycle performance; however, the low initial coulombic efficiency and poor electrical conductivity limit its applications in real batteries. In this study, electrodes were fabricated using two different conductive agents, and the resulting physical and electrochemical properties were analyzed. SEM observations confirmed the formation of a CNT conductive network throughout the electrodes, while the electrical conductivity contributed to the electrode was confirmed by impedance measurements. Thus, the electrode fabricated withthe CNT conductive agent showed greater capacity and superior cycle performance than did the electrode fabricated using the DB conductive agent. 본 연구에서는 도전재의 종류에 따른 리튬이차전지용 음극재인 SiOx의 전기화학적 특성 평가를 조사하였다. SiOx는 높은 이론 용량과 우수한 사이클 성능을 가지고 있어 최근 주목받고 있는 음극재 중 하나이다. 그러나 초기 비가역 용량이 원인인 낮은 초기 효율은 해결해야할 과제이며 낮은 전기전도도 역시 상용셀에 적용하기에 문제점으로 남아 있다. 본 연구에서는 형태가 다른 두종류의 도전재(denka black, carbon nanotube)를 사용하여 전극을 제작하고 물리적 특성과 전기화학적 특성을 평가하였다. SEM 분석에서 탄소나노튜브의 전도성 네트워크를 확인하였고 이로 인한 전기전도도의 기여는 임피던스 측정으로 확인하였다. 또한 탄소나노튜브의 전극에 대한 기여는 사이클 성능과 율속 특성 평가로써 확인하였다.
시각 자극 컨텐츠에 따른 긍정적 정서 행동 및 뇌파 반응 분석
연지원(Jiwon Yeon),임정민(Jungmin Im),김성필(Sungphil Kim) 한국HCI학회 2014 한국HCI학회 학술대회 Vol.2014 No.2
본 연구에서는 동일한 범주의 정서가(valence)에 속하는 컨텐츠의 다양성에 따라 사람의 정서반응에 차이를 보고자 하였다. 이를 위해 긍정적인 정서가의 IAPS(International Affective Picture System) 사진 데이터에 대해 주성분분석(Principal Component Analysis) 기법을 적용하여 가장 두드러지는 네 가지 컨텐츠를 확인하였다(아기, 스포츠, 음식, 풍경). 각 컨텐츠에 해당하는 사진을 별도로 수집한 후 20 명의 피험자에게 제시하여 정서반응과 EEG 신호를 수집하고, 시간에 따른 ERP 패턴을 주성분분석과 MDS(Multi-Dimensional Scaling) 알고리즘을 사용하여 그룹 간 유사성을 평가하였다. 분석 결과, 스포츠 컨텐츠가 가장 강한 감정 반응을 유발했으며 아기, 풍경 컨텐츠는 서로 유사한 행동 및 ERP 패턴을 나타내었다. 음식 컨텐츠의 경우 다른 컨텐츠에 비해 중립적인 범주의 사진과 가장 근접한 감정을 유발함을 알 수 있었다. 본 연구의 결과는 긍정적 감성을 위한 HCI 개발에 기반이 되는 신경과학적 이해를 넓히는 데 도움을 줄 것으로 예상된다. The present study investigated differences between the emotional responses according to the contents of same valence. To this end, IAPS(International Affective Picture System) picture data of positive valence was classified into four different contents (Baby, Sports, Food, and Sights) using Principal Component Analysis(PCA). Collected pictures of four contents were shown to 20 participants while their emotional responses and EEG(Electroencephalogram) signals were simultaneously recorded. Then, the ERP(Event Related Potential) signal was evaluated to find the similarities between the categories using the PCA and MDS(Multi-Dimensional Scaling) algorithms. The results show that sports contents elicited most strong emotion while baby and sight contents aroused similar behavioral responses and ERP patterns. Also, food contents induced emotion closest to the neutral pictures than the other contents. The result of this study may broaden our understanding for positive affective HCI (Human-Computer Interaction).
이명난청환자의 수용소음레벨과 자가보고 설문결과와의 관련성에 관한 연구
연지인,변재용,박문서,이재희 한국청각언어재활학회 2015 Audiology and Speech Research Vol.11 No.2
The present study aimed to identify whether subjects with tinnitus and hearing loss would tolerate noise poorly than subjects only with hearing loss. This study also evaluated whether the acceptable noise level (ANL) of listeners with tinnitus would be associated with results of self-reported subjective questionnaire. An experimental group (12 subjects with tinnitus and hearing loss) was compared to non-tinnitus control group (11 subjects with hearing loss), whose audiometric thresholds were statistically similar between two groups. Individual ANLs were measured across five types of background noise (1-male, 1-female, 2-talker, 4-talker, and 8-talker maskers). The self-reported subjective questionnaire evaluated individual subjective handicap of tinnitus and relevant depression. Results showed that the experimental group had relatively more annoyance from noise (higher ANLs) compared to control group, regardless of the type of background noise. From the results of subjective questionnaires, we found that listeners who reported more handicap of tinnitus had less tolerance of background noise (higher ANLs). In conclusion, tinnitus may affect subjective capacity to accept background noise while following a target story, and it can be related with subjective handicap from tinnitus.