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SO<sub>2</sub> 살균패드처리에 의한 감말랭이의 저장 중 품질 변화
오성일,김철우,이욱,Oh, Sung-Il,Kim, Chul-Woo,Lee, Uk 한국산림과학회 2016 한국산림과학회지 Vol.105 No.1
감말랭이의 $SO_2$ 살균패드처리($SO_2$ 0, 0.5, 1, 2 g/kg)에 의한 저장 중 품질에 미치는 영향을 조사하였다. 저장기간 동안 $SO_2$ 살균패드처리는 감말랭이의 중량 및 수분감소율과 가용성 고형물 함량에 영향을 미치지 않았다. 그러나 색차는 저장 12주 후 무처리구에서 3.5로 가장 높은 반면, $SO_2$ 2 g/kg 처리구에서 2.0으로 가장 낮게 나타났다. 감말랭이의 갈변도는 저장 12주 후 무처리구에서 0.24 O.D.로 가장 높았으며, $SO_2$ 0.5 g/kg 처리구 0.22 O.D.와 $SO_2$ 1 g/kg 처리구 0.20 O.D., $SO_2$ 2 g/kg 처리구 0.17 O.D.순으로 나타났다. 부패율은 저장 12주 후 무처리구가 7.0%로 가장 높은 반면, $SO_2$ 1 g/kg 처리구와 $SO_2$ 2 g/kg 처리구는 부패가 전혀 진행되지 않았다. 모든 $SO_2$ 살균패드 처리구에서 감말랭이의 잔류 이산화황 농도는 20.3~44.3 ppm으로 안전한 범위에서 검출되었다. 따라서 $SO_2$ 살균패드처리는 감말랭이의 갈변 및 부패를 억제시킴을 확인하였으며 특히, $SO_2$ 2 g/kg 처리가 감말랭이의 품질유지와 저장성에 가장 효과적이라고 판단된다. The effects of $SO_2$ treated pads ($SO_2$ 0, 0.5, 1, and 2 g/kg) on the quality of dried persimmons slices were investigated. The $SO_2$ treated pads for storage did not affect to weight, moisture loss rate, and soluble solid contents of dried persimmons slices. The color change after storage for 12 weeks was the highest (value = 3.5) in control ($SO_2$ 0 g/kg), whereas that was the lowest (value = 2.0) under $SO_2$ 2 g/kg condition. When we measured the browning degree after 12 weeks, they showed O.D. 0.24, 0.22, 0.20, and 1.7 in serial dilution treated pads with $SO_2$ 0, 0.5, 1, and 2 g/kg, respectively. The decaying rate was the highest (7.0%) in control after 12 weeks storage, whereas it did not show any spoilage in $SO_2$ 1 g/kg and 2 g/kg treated condition for whole storage period. The concentration of residual $SO_2$ in dried persimmons slices was detected within a safe range of 20.3~40.3 ppm. Therefore, the shelf-life of dried persimmons slices was lengthened in $SO_2$ treated pads (especially in $SO_2$ 2 g/kg) for inhibiting of browning and decaying.
근위축측삭경화증 환자에 동반되는 행동심리증상의 임상적 특징과 예후에 대한 영향
오성일,김희진,박아람,오기욱,곽현승,김승현 대한치매학회 2014 Dementia and Neurocognitive Disorders Vol.13 No.1
Background: The evaluation of behavioral and psychological symptoms (BPS) in ALS is important because its existence may serve as a prognostic factor and suggest a shared pathology with frontotemporal dementia (FTD) in ALS. In this study, we sought to identify the prevalence of the BPS of ALS patients and evaluate its relationship with the clinical profiles and survival of ALS patients. Methods: One hundred sixty-six patients were enrolled in a cross-sectional cohort analysis from September 2008 to February 2012. All patients had sporadic ALS without a genetic mutation and were collected clinical profiles. The t-test and chi-square test were used to assess differences in the clinical characteristics and caregiver-administered neuropsychiatric inventory (CGA-NPI) scores. The Kaplan-Meier method and Cox proportional hazard model were used for the survival analysis. Results: Forty-two patients had clinically significant BPS (42/166, 25.3%). ALS patients with BPS had worse clinical dementia rating (CDR), ALS Functional Rating Scale-Revised (ALSFRS-R) score, and progression rate of disease than those without BPS. Among CGA-NPI subscales, depression, irritability, apathy, and agitation were higher prevalent than the others. There was a trend for ALS patients with BPS having short survival time than those without BPS in the Kaplan-Meier analysis (p=0.006). However, in the Cox proportional hazard model, BPS in ALS patients were not associated with poor survival. Conclusions: These results support the presence of an overlapping spectrum between ALS and FTD and emphasize the importance of neuropsychiatric evaluations in ALS. Although the association between BPS and prognosis are not explained clearly, these results could be used to stratify ALS patients according to neuropsychiatric symptoms and help investigators to evaluate the BPS in ALS patients.
A Novel F45S SOD1 Mutation in Amyotrophic Lateral Sclerosis Coexisting with Bullous Pemphigoid
오성일,홍정호,최병우,오기욱,권민정,기창석,고주연,김승현 대한신경과학회 2015 Journal of Clinical Neurology Vol.11 No.4
Background Te coexistence of an autoimmune disease and amyotrophic lateral sclerosis (ALS) has led to the hypothesis that immune-mediated pathological mechanisms are overlapping in the two diseases. We report herein a rare coexistence of bullous pemphigoid (BP) in a novel mutation (F45S) of the gene encoding Cu/Zn superoxide dismutase (SOD1) in an ALS patient, and discuss a role for the SOD1 mutation in this unusual overlap. Case Report A 57-year-old male with familial ALS, including vesicles and tense bullae on erythematous bases, was diagnosed with BP. Direct immunofuorescence revealed deposits of C3 and immunoglobulin G in the basement membrane zone. Direct sequencing of SOD1 in the patient revealed a novel mutation (c.137T>C; F45S). Conclusions We report a novel SOD1 mutation in ALS, which was combined with BP. Tis novel SOD1 mutation could afect the phenotype of a combined autoimmune disease and matrix metalloproteinase-9. There may therefore be common factors linking BP and ALS with the SOD1 mutation.