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오갑진(Kap Jin Oh),최윤석(Yun Seuk Choi),최일식(Il Shik Choi),박시경(Si Kyung Park),이규흥(Kyou Heung Lee),정순간(Sun Gan Chung),조의환(Eui Hwna Cho) 대한약학회 1992 약학회지 Vol.36 No.5
Astilbes rhizoma has been used for headache, arthralgia, chronic bronchitis and stomachalgia in traditional chinese medicine. The analgesic activities and their components of Astilbe chinensis var. davidii Rhizomes were evaluated. The ether and ethylacetate fractions of 70% EtOH extract showed considerable analgesic activities by acetic acid induced writhing method. Compound 1~5 were isolated from ethylacetate fraction and identified as gallic acid, (+)-catechin, (+)-gallocatechin, bergenin and 11-O-galloylbergenin on the basis of spectroscopic methods. Among them (+)-gallocatechin showed stronger analgesic activity than that of other compounds.
안병태,오갑진,박시경,정순간,조의환,김재길,노재섭,이경순,Ahn, Byung-Tae,Oh, Kap-Jin,Park, Si-Kyung,Chung, Sun-Gan,Cho, Eui-Hwan,Kim, Jae-Gil,Ro, Jai-Seup,Lee, Kyong-Soon 한국생약학회 1996 생약학회지 Vol.27 No.3
Seven phenolic compounds were isolated from the leaves of Spiraea salicifolia. Their structures were characterized as cinnamic acid, ${\rho}-hydroxy$ cinnamic acid, ${\rho}-methoxy$ cinnamic acid, $1-O-coumaroyl-{\beta}-D-glucopyranose$, $1-O-caffeoyl-{\beta}-D-glucopyranose$, hyperoside and quercetin $3-O-(6'-O-{\alpha}-L-arbinopyranosyl)-{\beta}-D-galactopyranoside$ by chemical and spectroscopic evidence.
한국산 복수초성분의 Na<sup>+</sup>, K<sup>+</sup>-ATPase활성에 대한 연구
노재섭(Jai Seup Ro),이경순(Kyong Soon Lee),박웅양(Woong Yang Park),오갑진(Kap Jin Oh),안병태(Beung Tae Ahn),어경춘(Kyong Chun Eo),정도래(Do Rae Jeong),Toshio Nambara(Toshio Nambara) 한국생약학회 1990 생약학회지 Vol.21 No.2
Four known cardiotonic steroids were isolated from roots of Adonis amurensis Regel et Radde and identified as digitoxigenin, cymarin, K-strophanthin and convallatoxin by chromatography on Amberlite XAD-2 zesin and silica gel, highperformance liquid chromatography and gel chromatography on Sephadex LH-20. In order to clarify the structure-activity relationship, thirteen related compounds of digi toxigenin were tested for the inhibitiory activities for Na^+, K^+-adenosine triphosphatase from guinea pig heart. The inhibitory activities of related compounds of digitoxigenin were dependent upon the dicarboxylic acid and amino acid components. The compound having both the arginine and suberic acid moiety showed the higher inhibitory activity. The sulfate and glucuronide of digitoxigenin exhibited much less potency than the parent genin.