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Benfuracarb 원제에 함유된 불순물들의 glutathione-S-transferase와 amidase 저해 특성
염창섭(Chang-Sub Yum),김성문(Songmun Kim),유지숙(Ji Sook Yu),허장현(Jang-Hyun Hur) 한국농약과학회 2002 농약과학회지 Vol.6 No.1
Objectives of this study were to determine if impurities in technical grade benfuracarb inhibit glutathione-S-transferase and amidase and to identify structures of impurities in technical grade benfuracarb. Technical grade benfuracarb, active ingredient, and impurity inhibited glutathione-S-transferase, and their I?? were 9.7×10?⁴ M, >1.0×10?³ M, 1.8×10?⁴ M, respectively. Such inhibition, however, was not higher than that by ethacrynic acid, a selective inhibitor to GST. Technical grade benfuracarb, active ingredient, and impurity also inhibited amidase, and their I?? were 6.0×10?? M, 4.3×10?⁴ M, 7.6×10?? M, respectively. Our results show that the inhibition of both detoxifying enzymes by impurities in benfuracarb was 10-fold lower than that by active ingredient, suggesting that both active ingredient and impurities are involved in the inhibition of both detoxifying enzymes. Of four impurities (IM 1~4) that were separated from technical grade benfuracarb, IM 2 and IM 3 inhibited GST and amidase. Based on data from IR, ¹H-NMR, ¹³C_NMR and MS, it was determined that IM 2 is ethyl-N-isopropylamino propionate and IM 3 is ethyl-N-isopropyl-N-(chlorosulfenyl)aminopropionate.
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