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연은숙,박지원,김수자,장혜경,김옥녀 한국병원약사회 1999 병원약사회지 Vol.16 No.1
Ciprofloxacin is one of synthetic fluoroquinolone antibacterial agents which has great bactericidal activity against Gram negative aerobic organisms (especially, Enterobacteriaceae and Pseudomonas aeruginosa) and Gram positive bacteria (including Penicillinase-producing and Methicillin-sensitive Staphylococcus aureus). However, the appearance of ciprofloxacin resistant to many different microorganisms limits the use of ciprofloxacin for patients who are really needed it. This sudy was performed to analyzed the appropriateness for ciprofloxacin use in St. Mary's Hospital setting. Forty-one charts of patients who used ciprofloxacin (Ⅳ) (M/F 24/17, Jan.-Aug. of 1998) underwent drug utilization evaluation (DUE). The criterias of DUE used in this study were based on the standards by the American Society of Hospital Pharmacy which modified to be appropriate in our hospital setting : 1) Justification of drug use, 2) Critical & process indications, 3) Complications, 4) Outcome measures. Justification of use showed high appropriate rate (87.8%). Most of the critical & process indications also showed high appropriate rates (82.9 thru 97.5%) except C&S test during ciprofloxacin use (60.9%). Complications in ciprofloxacin use were usually minor symptoms such as pruritis (2.4%) and GI problems (39.0%). Also these study datas demonstrated other factors such as drug-drug interactions and co-disease could influence the complications. In case of outcome measures, the total therapeutic response showed high rate (95.1%). Only two patients (4.8%) had no response to ciprofloxacin at all. This study shows DUE analyzed for the appropriateness and problems of ciprofloxacin use. Therefore, DUE to a specific drug can apply to improve the efficacy of drug use and quality of medical service.
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오구멘틴^(R)시럽과 메피롤^(R)시럽 혼합액의 안전성 평가
방현경,연은숙,강진숙,최귀령 한국병원약사회 2003 병원약사회지 Vol.20 No.2
A study was carried out using HPLC to determine the chemical stability of Augmentin^(R) oral suspension (Amoxicillin and Potassium Clavulanate) and Mephirol^(R) syrup (Sobrerol and S-Carboxylmethycysteine) mixture, stored at 2~8℃ over a period of 7days. Augmentin^(R) suspension is reported to be stable for at least 7days in a refrigerator. Our main objective was to study its stability in Augmentin^(R) suspension and Mephirol^(R) syrup mixture. During the study period, amoxicillin component was found to be more stable than the clavulanate. But in a tendency, there were little difference between the Augementin^(R) suspension and the mixture. An increase in the pH of the samples was also observed as an increase in Mephirol^(R) syrup ratio. Despite the pH increase, no additional HPLC peaks were noted. On the basis these results, it is suggested that likewise the Augmentin^(R) suspension. Augmentin^(R) suspension and Mephirol^(R) syrup mixture is stable for 7days in a refrigerator.
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