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골수염 치료제인 항생제비드 ( CJ-40003 ) 유효성분의 일반약리작용
김영훈(Young Hoon Kim),최재묵(Jae Mook Choi),온윤성(Yoon Seong On),연규정(Kyu Jeong Yeon),이윤하(Youn Ha Lee),김제학(Je Hak Kim),이영수(Young Soo Lee) 한국응용약물학회 1999 Biomolecules & Therapeutics(구 응용약물학회지) Vol.7 No.1
A new antibiotic bead, CJ-40003 is a combination of three antibiotics, tobramycin, vancomycin and cefazolin embedded in bone cement, for the treatment of osteomyelitis. To evaluate the general pharmacological properties of CJ-40003, the effects of its active ingredients were investigated in mice, rats, dogs and isolated guinea pig ileum. The combination of three antibiotics (CA) did not affect general behavior, central nervous system, smooth muscles, gastrointestinal system, cardiovascular and respiratory system and water and electrolytes excretion when administered intravenously at the doses of 0.3, 1 and 3 mg/kg, respectively, into experimental animals. The CA had no effect on the contractile response of the isolated guinea pig ileum to various spasmogen at concentrations of 1, 3 and 10 ㎍/ml, respectively. In conclusion, the active ingredients of CJ-40003 showed no pharmacological effect in these studies.
이용연,조정효,이연월,손창규,조종관,황규정,유화승,Lee, Yong-Yeon,Cho, Jung-Hyo,Lee, Yeon-Weol,Son, Chang-Gue,Cho, Chong-Kwan,Hwang, Kyu-Jeong,Yoo, Hwa-Seung 대한약침학회 2001 Journal of pharmacopuncture Vol.4 No.3
Objective: The purpose of this study is to develop and activate anti-tumor herbal acupuncture for cancer patients in South Korea. Methods: We investigated some literatures on anti-tumor herbal acupuncture which is used in South Korea and China, and made diagrams. Results: The results are summarized as follows. Anti-tumor herbal acupuncture is one of the traditional oriental medical method which is effective for cancer patients. In domestic studies, most of herb materials are belong to action of cooling&detoxification(25.0%) and strengthening body resistance(46.4%) which are proved to have effects of anti-tumor, immune activation and preventing tumor. In China, point injection therapy are used for improving symptoms of cancer patients and hea1ing tumor. Also herbal intravenous injection is used for combination of chinese traditional and western cancer therapy and treating cancer patients variously. Conclusions: From the above results. it is expected that anti-tumor herbal acupuncture is useful to improve clinical symptoms and quality of life(QOL) of cancer patients. Also we must develop new progressive methods of point injection and herbal intravenous injection for treating cancer patients, and advance clinical studies and trials.