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消癌散의 경구투여에 의한 마우스 B16 흑색종 세포의 폐전이에 대한 항전이 효과
주성민,양휘훈,우원홍,정우열,조원준,이기영,전병훈,김원신 대한동의생리학회,대한동의병리학회 2001 동의생리병리학회지 Vol.15 No.6
We have examined the inhibitory effect of oral administration of Soamsan, a Korean traditional medicine, on lung metastasis by inoculation of mouse B16 melanoma cells into the tail vein. Oral administration of Soamsan for 20 days after tumor inoculation resulted in dose-dependent inhibition of lung metastasis. Soamsan at the dose of 40 mg/day/mouse for 20 days significantly inhibited the metastasis. Treatment with Soamsan (40 mg/days/mouse) for 7 days before and after tumor inoculation result in significant inhibition of lung metastasis. On the other hand, in the case of treatment with Soamsan for 7 days after 7 days from tumor inoculation, the inhibitory effect was not detected. Soamsan significantly inhibited the lung metastasis of B16 melanoma cells in mice pretreated with anti-mouse NK 1.1 monoclonal antibody and untreated nomal mice, whereas it did not inhibit efficiently metastasis in 2-chloroadenosine-pretreated mice. Also, Soamsan enhanced the antigen specific immune response by stimulating the activation of B lymphocytes (Kim et al., 2001). These results suggest that oral administration of Soamsan inhibited lung metastasis of B16 melanoma cells, possibly through a mechanism mediated by the activation of marcrophages and B lymphocytes in the host immune system.
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