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Tomographic visualization of tissue compositional changes in human breast model
Yijie Yang(양이지에),Sehyun Shin(신세현),Megha Singh(메가싱) 대한기계학회 2006 대한기계학회 춘추학술대회 Vol.2006 No.6
Human breast is a soft tissue structure. The changes in the compositional variation especially at the onset stage of cancer could better be visualized by optical tomography, which depend on the refractive index variation compared to mammography. The latter technique depends on the variation of attenuation coefficient which could be an important parameter during the progression of the tumor. The objective of the present work is to simulate the optical tomographic procedure on breast tissue models. The breast model is made of goat fat tissues. In this the inclusions of tissues of varying optical parameters are inserted at different locations. The optical parameters of the inclusions are higher than that of fat tissues. Optical tomography reconstruction of breast phantom is carried out in parallel beam configuration. The tomographic images are further processed by various image processing procedures. The results show that the tissue compositional variation and size of the various tissues inserted into model are well resolved by this procedure.
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Microchip-based cell aggregometer using strring disaggregation mechnism
신세현,양이지에,서장수 한국유변학회 2007 Korea-Australia rheology journal Vol.19 No.3
A new microchip-based aggregometer that uses a stirring-aided disaggregation mechanism in a microchip was developed to measure red blood cell (RBC) aggregation in blood and RBC suspensions. Conventional methods of RBC disaggregation, such as the rotational Couette system, were replaced with a newly designed stirring-induced disaggregation mechanism. Using a stirrer in a microchip, the aggregated RBCs stored in a microchip can be easily disaggregated. With an abrupt halt of the stirring, the backscattered light intensity can be measured in a microchip with respect to time. The time recording of the backscattered light intensity (syllectogram) shows an exponential decreasing curve representing the RBC aggregation. By analyzing the syllectogram, aggregation indices such as AI and M were determined. The results showed excellent agreement with LORCA. The essential feature of this design is the incorporation of a disposable microchip and the stirring-induced disaggregation mechanism.
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