Silencing of Cytosolic NADP+-dependent Isocitrate Dehydrogenase Gene Enhances Ethanol-induced Toxicity in HepG2 Cells

양은선,Su-Min Lee,박진우 대한약학회 2010 Archives of Pharmacal Research Vol.33 No.7

It has been shown that acute and chronic alcohol administrations increase the production of reactive oxygen species, lower cellular antioxidant levels and enhance oxidative stress in many tissues. We recently reported that cytosolic NADP+-dependent isocitrate dehydrogenase (IDPc) functions as an antioxidant enzyme by supplying NADPH to the cytosol. Upon exposure to ethanol, IDPc was susceptible to the loss of its enzyme activity in HepG2 cells. Transfection of HepG2 cells with an IDPc small interfering RNA noticeably downregulated IDPc and enhanced the cells’ vulnerability to ethanol-induced cytotoxicity. Our results suggest that suppressing the expression of IDPc enhances ethanol-induced toxicity in HepG2 cells by further disruption of the cellular redox status.

Involvement of Endoplasmic Reticulum Stress Response in Orofacial Inflammatory Pain

양은선,배진영,김태헌,김윤숙,석경호,배용철 한국뇌신경과학회 2014 Experimental Neurobiology Vol.23 No.4

Endoplasmic reticulum (ER) stress is involved in many neurological diseases and inflammatory responses. Inflammatory mediatorsinduce neuronal damage and trigger the neuropathic or inflammatory pain. But there is very little data on the role of the ER stressresponse in pain mechanisms. In this study, we explored whether the ER stress response is involved in orofacial inflammatorypain by using a complete Freund’s adjuvant (CFA)-injected rat model. The thermal pain hypersensitivity increased significantlyafter CFA injection. We found that the protein and mRNA levels of ER stress response genes, GRP78/Bip and p-eIF2α, increasedsignificantly in trigeminal ganglion (TG) of CFA-injected rats compared to control animals. In immunofluorescence analysis, asignificant increase of GRP78 and p-eIF2α immunopositive neurons was observed in CFA-injected TG compared to control TG. When we administered an ER stress modulator, salubrinal, CFA-induced thermal pain hypersensitivity was temporally reduced. Thus, our study suggests that ER stress responses in TG neurons contribute to CFA-induced inflammatory pain, and may comprisean important molecular mechanism underlying the orofacial inflammatory pain pathway.

四時廻文詩의 문예미학적 특징 — 宇文虛中의 <四序廻文十二首>를 중심으로

양은선 중국어문연구회 2019 中國語文論叢 Vol.0 No.96

The twelve palindrome poems of four seasons are Wuwen-Xuzhong’s series of poems composed of five character quatrain in the Northern Song Dynasty and the early Jin Dynasty. The palindrome poems of four seasons are is the first form of poetry in Song Dynasty. Wuwen-Xuzhong’s works are a combination of the form of palindrome and the content of four seasons’ songs. The characteristics of literary aesthetics of his work can be divided into three parts. This poetry develops with the passage of seasonal time. It contains the seasonal circular beauty of the four seasons’ songs in content, the form of palindrome can be said to have achieved a circular beauty in the form. Second, coupling thinking and symmetrical beauty. The combination of poems is closely related to the coupling thinking of China, this kind of coupling thinking mode is also related to symmetrical thinking. In a joint sentence of each sentence, nouns are symmetrical with nouns, and verbs are symmetrical with verbs. Third, the diversity and lyrical beauty of images. It is difficult to use multiple images with a five character quatrain, but his works use visual, auditory, kinesthetic and other images through the way of composing poems. Besides, it is different from the general four seasons songs, which restrains the emotional expression of the author, focuses on describing the changes of the objective scenery and strengthens the lyricism.

金代 중기 王庭筠 시 연구

양은선 중국어문연구회 2020 中國語文論叢 Vol.0 No.97

The literary school in the state Dynasty is an active group of writers in the period of Dading and Mingchang in the Jin Dynasty. Wang Tingyun is the main character of “respecting and leading the Tang Dynasty” in the literary school in the state dynasty. The characteristics of his poems can be summed up in three aspects. First, of his 44 poems, 27 are in the form of quatrains. The artistic conception of these works is very similar to that of Tao Yuanming, Li Bai and Wang Wei in the flourishing period of Tang Dynasty. Second, Wang Tingyun, who is not only an outstanding painter, but also has the experience of appraising the paintings collected by the royal family, has a considerable number of poems of landscape paintings. Through these works, we can find that he follow Wang Wei’s landscape painting and Su Shi’s theory of Same Rules of Paintings and Poems. Third, generally speaking, he inherited the style of Huang Tingjian’s poems, but his works are closer to the artistic conception of Wang Wei’s and Meng Haoran’s landscape poems.

李商隱 <燕臺詩>의 ‘환상성’

양은선 고려대학교 중국학연구소 2009 中國學論叢 Vol.26 No.-

李商隱的<燕臺詩>究竟是‘愛情詩’或者反映現實的詩的問題一直在爭論。大部分學者一般認爲<燕臺詩>是無題詩的一種。因爲在<燕臺詩>裏籠罩조著幻想的氣氛。但是<燕臺詩>的眞正價値不是在主題思想,而是就在‘幻想’自身。 <燕臺詩>的‘幻想’由幾個因素來構成。第一,詩題的模糊性。詩題的‘燕臺’跟詩的內容毫無關涉。這就可以引起‘幻想’。第二,時間, 空間境界的模糊性。李商隱描寫四個季節不但已經擺脫中國傳統的意象,而且不是按照時間的順序來描寫的。但是作者通過這種方法來表達的就是對歲月茫然虛度的可惜的感覺。關於空間的就是南方和北方的問題。詩題的‘燕臺’就是北方,不過詩裏描寫的大部分是南方的風景。但這不是實際的風景,而是作者所想象的風景。第三,意象的多樣性。比如關於女性的意象和男性的意象合在一起,對未來的希望和對現實的絶望合在一起等。第四,唐代流行的道敎思想。在<燕臺詩>裏關於道敎出現的就是‘夢’和跟道敎直接關係的詩語。 總之,藝術的本質在‘非使用’的,爲‘非使用’最有效的方法就是幻想。所以只要擺脫中國傳統的傳記批評和效用論的讀詩態度,才能發現<燕臺詩>的眞正的價値。

우리 교회 명교사를 소개합니다

양은선 장로회신학대학교 기독교교육연구원 2013 교육교회 Vol.424 No.-

《文心雕龍》第十九 <詔策> 篇 解題 및 譯註

양은선 한국중국문학이론학회 2010 중국문학이론 Vol.13 No.-

이상은(李商隱) <연대시(燕臺詩)>의 "환상성"

양은선 고려대학교 중국학연구소 2009 中國學論叢 Vol.26 No.-

李商隱的<燕臺詩>究竟是`愛情詩`或者反映現實的詩的問題一直在爭論。大部分學者一般認爲<燕臺詩>是無題詩的一種。因爲在<燕臺詩>裏龍조著幻想的氣분。但是<燕臺詩>的眞正價値不是在主題思想, 而是就在`幻想`自身。<燕臺詩>的`幻想`由幾個因素來構成。第一, 詩題的模糊性。詩題的`燕臺`근詩的內容毫無關涉。這就可以引起`幻想`。第二 時間·空間境界的模糊性。李商隱描寫四個季節不但已經擺脫中國傳統的意象, 而且不是按照時間的順序來描寫的。但是作者通過這種方法來表達的就是對歲月茫然虛度的可惜的感覺。關於空間的就是南方和北方的問題。詩題的`燕臺`就是北方, 不過詩裏描寫的大部分是南方的風景。但這不是實際的風景, 而是作者所想象的風景。第三, 意象的多樣性。比如關於女性的意象和男性的意象合在一起, 對未來的希望和對現實的絶望合在一起等。第四, 唐代流行的道敎思想。在<燕臺詩>裏關於道敎出現的就是`夢`和근道敎直接關係的詩語。總之, 藝術的本質在`非使用`的, 爲`非使用`最有效的方法就是幻想。所以只要擺脫中國傳統的傳記批評和效用論的讀詩態度, 才能發現<燕臺詩>的眞正的價値。

주거환경과 아동 문제행동의 관계에서 어머니 우울감의 매개 효과

양은선,김연하 한국아동권리학회 2021 아동과 권리 Vol.25 No.3

Objectives: The purpose of this study was to investigate the link between housing environments and behavioral problems of children. The mediating role of maternal depression between the two variables was also explored. Methods: Participants in this study were 1,716 children aged 9 to 17 and their mothers, with data sourced from the 2013 Korean National Survey of Children and Youth. The data were analyzed with descriptive statistics, Pearson’s correlations, and hierarchical regressions including control variables. Results: Significant links between housing environment, maternal depression, and child behavioral problems were found. A low-quality housing environment as perceived by mothers was associated with high rates of depression in mothers and high levels of behavioral problems in their children. Maternal depression partially mediated the negative link between the quality of the housing environment and behavioral problems in children. Conclusions: Housing environments have clear effects on the social-emotional development of children and maternal mental health plays an important role in the link between the housing environment and the development of the child. 연구목적: 본 연구는 주거환경과 아동 문제행동의 관련성을 살펴보고, 주거환경과 아동문제행동의 관계에서 어머니 우울감이 매개적 역할을 하는지 탐색하고자 하였다. 방법: 아동종합실태조사의 2013년도 자료를 사용하였으며, 아동이 만 9세 이상 18세 미만이고 주 양육자가 어머니인 경우를 연구대상으로 하여 총 1,716명의 자료를 분석하였다. 자료 분석에는 기술통계 분석, Pearson 적률상관관계 분석, 통제변인을 투입한 위계적 다중회귀분석을 사용하였다. 결과: 주거환경, 어머니 우울감, 아동 문제행동은 서로 유의미한 상관관계가 있는 것으로 나타났다. 어머니가 주거환경을 적합하지 않다고 지각할수록 어머니 우울감이 높았고, 아동문제행동 수준도 높았다. 그리고 어머니 우울감은 어머니가 지각한 주거환경 수준과 아동 문제행동의 부적 영향 관계에서 부분 매개 역할을 하였다. 결론: 본 연구는 주거환경이 아동의 사회정서 발달에 영향을 미칠 수 있는 중요한 요인이며, 주 양육자의 정신건강은 주거환경과 아동 발달 사이에서 주요한 매개 역할을 한다는점을 확인하였다.

원호문(元好問)의 두시(杜詩) 인용(引用)의 특징과 그 의의

양은선 고려대학교 중국학연구소 2013 中國學論叢 Vol.41 No.-

元好問是金元時期代表詩人, 因其詩歌中還包含著唐宋詩的風格, 所以歷代批評家都認爲他是唐宋詩的集大成者. 然而他的詩歌中也有還未得到文學批評家們充分重視的作品, 譬如‘引用詩’. 他的引用詩一共有200餘句, 其中關於唐代杜甫詩的引用詩大約有110首.引用杜詩的元好問詩歌有三個特徵. 第一, 直接引用杜甫的抒情的詩句. 元好問把杜甫表達感情的詠懷詩句直接引用在自己的詩裏. 第二, 因通過杜詩的引用而擴大了詩的時空間的背景. 第三, 詩句的飜案.元好問引用杜詩的文學意義之一就是主觀情緖的客觀化. 元好問把杜甫的詩句使用爲客觀對應物. 這使不僅흔有效地傳達詩人的感情, 而且容易形成與讀者之間的紐帶. 元好問引用杜詩的文學價値除了主觀情緖的客觀化以外, 還有抒情詩的敍事化. 元好問通過杜詩的敍事的背景來設定了自己作品的背景. 這使元好問的抒情詩變成爲帶著杜詩故事的一種敍事詩. 第三,景物描寫的繪畵美. 元好問寫作山水詩時像繪書一樣變描寫化無窮的山水奇景. 他引用杜甫的詩句時也偏愛反映這種山水詩的技巧的.