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양성희 ( Seong Hee Yang ),이기재 ( Kee Jae Lee ),유기연 ( Ki Yon Rhew ) 한국보건정보통계학회 2016 보건정보통계학회지 Vol.41 No.2
Objectives: Proper use of antibiotic for the treatment of acute otitis media (AOM) is important because it can improve the treatment effect and can reduce the risk of antibiotic-resistant bacteria. There has been no national wide study on the antibiotic use for AOM treatment in young ages in Korea. Therefore, we conducted a national wide study on the status of antibiotic prescription for the AOM treatment in young ages in Korea. Methods: The AOM outpatient data on the antibiotic prescription was obtained from Korean health insurance review and assessment service. The ratio and the factors influencing (type of AOM, patient’s age group, types of hospitals, specialty of the physician and the regions in Korea) on the antibiotic prescription was analyzed using multivariate binary logistic regression. Results: Total 388,994 cases were analyzed. The antibiotic was prescribed in 89.0%. Antibiotics were prescribed the most frequently in the pre-school ages (odds ratio [OR] 1.05; 95% confidence interval [CI], 1.00-1.11) and the least frequently in the adolescents (OR 0.81; 95% CI, 0.75-0.88). The suppurative AOM was more related to the use of antibiotics than non-suppurative AOM (OR 1.44; 95% CI, 1.39-1.50). The secondary hospital (OR 3.19; 95% CI, 2.65-3.85) and primary hospital (OR 8.40; 95% CI, 6.97-10.12) prescribed antibiotics more frequently compared to the tertiary hospital. Conclusions: Various factors are related to prescribing antibiotics for the treatment of AOM in pediatric patients. Antimicrobial prescribing guidelines for pediatric AOM patients would encourage appropriate use of antibiotics.
한국임상약학회지에 게재된 논문의 통계 분석기법에 대한 고찰
양성희 ( Seong Hee Yang ),이태림 ( Tae Rim Lee ),이숙향 ( Suk Hyang Lee ),유기연 ( Ki Yon Rhew ) 한국보건정보통계학회 2012 보건정보통계학회지 Vol.37 No.1
Objectives: Statistical analysis is fundamental to demonstrate internal validity of study results. The purpose of this study is to review statistical methods and errors in articles published in the Korean Journal of Clinical Pharmacy (KJCP). Methods: We reviewed appropriateness and validity of statistical methods in articles published in the KJCP from 2006 through 2010 using checklist for assessing the methodological and statistical validity. Frequency of applied inferential statistical methods and errors were analyzed using SPSS(R) version 12.0. Results: Total 85 original articles were reviewed. Among them, 19 articles used the descriptive statistics only, and 66 articles used both descriptive and inferential statistics. Frequently used methods were ANOVA (23.8%), t-test (19.8%), and χ2 test (12.9%). Errors of omission were found 45 times in 36 articles and errors of commission were found 41 times in 30 articles. Only 39.4% of papers were free from statistical errors. Conclusions: We could found various types of statistical errors in the articles published in the KJCP.Clinical researchers need to be more cautious in applying statistical methods of study to ensure internal validity of results.
박창선(Chang Sun Park),배성미(Seong Mee Bae),양성희(Seong Hee Yang),황보신이(Shinn Hwangbo),홍경자(Kyung Ja Hong),장춘곤(Choon Gon Jang),이석용(Seok Yong Lee) 대한약학회 2002 약학회지 Vol.46 No.1
The elderly patients are the most frequent users of digoxin because of increased prevalence of the two primary indications for digoxin therapy; atrial fibrillation (AF) and congestive heart failure (CHF). This study was Performed to observe a variation in digoxin pharmacokinetic parameters in advancing age and changing kidney function, and to compare the measured clearance with the calculated clearance. The 123 drug monitoring records of inpatients who had achieved steady state concentration of digoxin at a tertiary hospital from April 1999 to October 2001 were reviewed. In advancing age, measured digoxin clearance, volume of distribution and creatinine clearance were reduced. Compared with the calculated digoxin clearance, the measured digoxin clearance was more reduced in patients without CHF Especial1y: in elderly patents without CHF the measured digoxin clearance was lower than the calculated digoxin clearance. In contrast to non-CHF patients the measured value was greater than the calculated value in all CHF patients. Findings from this study indicate that the calculated digoxin clearance in elderly patients without CHF substantially overestimated the true clearance. Thus, it appears that the use of calculated digoxin clearance to estimate serum digoxin concentration may result in underestimation of the true serum concentration in a number of elderly patients without CHF.
조항석(Hang Suk Cho),오병훈(Byoung Hoon Oh),양성희(Seong Hee Yang),이혜리(Hye Ree Lee),유계준(Gye Joon Yoo) 대한노인정신의학회 1998 노인정신의학 Vol.2 No.2
Ojectives : Patients with dementia are accompanied with poor autonomy and multiple disability. Therefore moer cost and medical service are required than non-dementia patients. In order to insure comprehensive, systematic care for dementia patients, knowledge of the associated disease of different types of dementia is warranted. This study evaluate the characteristics of associated disease in inpatients with dementia, to be used as basic reference for effective treatment. Methods : The study popultion consist of 92 patients with dementia admitted between January 1, 1996 and September 30, 1997 to geriatric department, Yosei University Kwangju Severance Psychiatric Hospital. Diagnoses were based on DSM-IV and NINCDS. Severity of dementia was evaluated by GDS (Global Deterioration Scale). Associated diseases was recorded in separated checklist. χ-test, Fisher's exact test, ANOVA, T-test, Wilcoxon rank sum test, Kruskal-Wallis test were used to determine statistical differences among the dementia subgroup. Results : The mean age was 71.8±9.2 with 31 male (33.7%) subjects and 61 female subject (66.3%). The types of dementia among the 92 demented patients were as follows : 50 (54%) with Alzheimer's disease, 30 (33%) with vascular dementia, 12 (13%) with unclassified dementia. Mean GDS score was 5.4±1.1. The mean duration of admission was 66.9±88.9 days. Types of discharge were normal discharge 33 (35.9%), discharge against doctors' advice 28 (30.4%), transfer 23 (25.0%). The average number of diagnoses was 4.9±2.4. (4.5±2.4 in Alzheimer's disease, 6.1±2.4 in vascular dementia, 5.3±2.1 in unclassified dementia in respectively (p<0.05). The most common associated disease were gastrointestinal disorders (24.8%), cardiovascular disorders (11.8%), urinary tract infection (6.8%), musculoskeletal disorder (6.6%), diabetes mellitus (4.5%). Associated diseases that their frequency showed significant differences in different types of dementia were hypertension, diabetes mellitus, urinary incontinence, oral cavity disease, anemia (p<0.01). Conclusions : Associated disease are different in different type of dementia. Patients with vascular dementia had more associated disease and received more drugs for associated disease than Alzheimer's disease. Our data emphasize comprehensive and systematic treatment plan according to type of dementia.
양성희,배성미,김순주,황보신이 한국병원약사회 2002 병원약사회지 Vol.19 No.3
Digoxin is a cardiac glycoside used for treatment of congestive heart failure(CHF) or atrial fibrillation. Because of the narrow therapeutic index and large interpatient pharmacokinetic variability, it is necessary to monitor the serum drug level. We collected routine clinical pharmacokinetic(PK) data from patients receiving digoxin therapy and analysed the patient's characteristics and digoxin PK parameters. Also we evaluated the acceptability rate of the recommendation and the causes of the sub or upper-therapeutic level. Of all the 408 patients, the old over 60 years was 282 patients(69%). The mean half life was 81.8±31.2hours and 48.1% was ranged from 50 to 79hours. For volume of distribution(Vd), the mean was 6.7±2.0L/㎏and 64.5% was ranged from 5.0 to 7.9L/㎏. One way ANOVA test showed that the variable with the greatest predictive value for digoxin PK parameters was creatinine clearance. The most reason for requests from physician was to confirm the appropriate dose(86.9%) and the total acceptability rate was 72.6%. Sub-therapeutic level was caused by low dose(37.4%), non-steady state concentration(24.9%) and noncompliance(11.5%). Upper-therapeutic level was caused by high dose(73.4%)and wrong sampling time(12.9%). We concluded that the clearance of digoxin was mainly influenced by creatinine clearance. But in the recommendation for the older patients, aging-related changes in renal function, body mass and possible interactions must be considered. Pharmacy based clinical pharmacokinetic consultation service can provide benifits by recommending appropriate dose and sampling time. For the more, patients instruction can improve therapeutic effect of digoxin.