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위암종에서 p53 유전자 산물에 대한 면역조직화학적 연구
류도현(Do Hyun Rheu),주영은(Young Eun Joo),김태두(Tai Du Kim),지미선(Mi Sun Ji),양대현(Dai Hyun Yang),유종선(Chong Sun Rew),박창수(Chang Soo Park),윤종만(Chong Mann Yoon) 대한내과학회 1995 대한내과학회지 Vol.48 No.4
bronchogenic carcinoma and breast cancer. Although gastric cancer is the most frequent tumor in Korea, few article was reported about the mutation of p53 gene in gastric cancer. In this study, immunohistochemical staining for the mutant p53 gene product was performed to see the relation of the mutation of p53 gene to the pathologic type and staging in the gastric cancer, and to evaluate the usefulness of the mutant p53 gene as a index of gastric cancer. Methods: The mutation of p53 gene was studied with immunohistochemical staining of paraffin section which was obtained in the surgically resected 87 gastric cancer patients. Results: 1) Positive reaction for p53 gene product was observed mainly in the nuclei of tumor cells and negative reaction was observed in the normal mucosal epithelium around cancer foci. 2) The positivity of p53 gene product was 61.2% of the gastric carcinoma overall. By the histological differentiation, the positivity was 57.7% in the well differentiated adenocarcinoma, 60% in the moderately differentiated adenocarcinoma and 72.5% in the poorly differentiated adenocarcinoma, Poorly differentiated adenocarcinoma revealed the highest positivity(p<0.05). 3) Positive cell ratio of p53 gene product in cancer nest had a increased tendency in the poorly differentiated rather than in the well differentiated adenocarcinoma. Conclusion: From the above result, the mutation of p53 gene was highly expressed in gastric cancer and positive reaction of p53 gene product was highly increased in poorly differentiated cancer cell.
만성 췌장염에서 Camostat Mesilate ( FOIPAN(R) ) 의 임상 효과
김영진 ( Young Jin Kim ),유종선 ( Jong Sun Rew ),윤종만 ( Chong Mann Yoon ),양대현 ( Dai Hyun Yang ) 대한소화기학회 1993 대한소화기학회지 Vol.25 No.1
N/A A potent oral protease inhibitor, Camostat Mesilate (FOIPAN), was developed for the therapeutic agent in chronic pancreatitis. The clinical effects were evaluated in 25 patiented with chronic pancreatitis. 200 mg of FOIPAN' was given t.i.d. orally for 4 weeks. FOIPAN was very effective in the alleviation of the suhjective symptoms such as abdomilial pain, nausea and vomiting, indigestion and abdominal full#oess#. The global utility rate of the FOIPAN in the chronic pancreatitis was 76.0%. It was most effective in the patients with elevated serum amylase level. There were no significant side effects during the clinical trial. It could be said that FOIPAN was a safe and effective drug in the treatment of chronic pancreatitis.
간경변증 환자에서 위내 적색반과 혈청 Pepsinogen 1 치에 관한 연구
김미정(Mi Jung Kim),안영주(Young Joo An),양대현(Dai Hyun Yang),유종선(Jong Sun Rew),윤종만(Chong Mann Yoon) 대한내과학회 1993 대한내과학회지 Vol.45 No.2
Background: Gastric mucosal lesions in chronic liver diseases are uncommon. However, the pathogenesis and mechanism of gastric mucosal lesions are unclear. To investigate the cause of gastric red spots (Mucosal vascular ectasia), we measured fasting serum pepsinogen I level. Method: To investgate the secretory function of gastric mucosa in liver cirrhosis and the causes of gastric red spots, we measured fasting serum pepsinogen. I. Forty-one subjects were studied: ten with liver cirrhosis showing endoscopic gastric red spots, sixteen with liver cirrhosis not showing gastric lesions, and twenty-five normal controls. Result: In control groups, the results showed higher levels of serum pepsinogen I in smokers than in nonsmokers. Serum Pepsinogen I levels were significantly lower in cirrhotic patients than normal control groups (73.64±4.65ng/ml vs, 118.85±5.45ng/ml: p<0.001) and were significantly lower in cirrhotic patients with gastric red spots than in cirrhotics without these lesions (57.78±7.02ng/ml vs. 83.55±4.81ng/ml: p<0.005). Serum pepsinogen I levels were not influenced by the etiology of liver cirrhosis, the form of esophageal varices, and severity of liver cirrhosis. Conclustion: Serum pepsinogen I levels were significantly lower in cirrhotics and especially much lower in cirrhotics with gastric red spots than without these lesion, and these results suggest that the pathogenesis of gastric red spots may be related to the decreased levels of serum pepsinogen I.
김영진,범희승,조규혁,정용환,정상우,김세종,유종선,신동현,윤종만,양대현,성종호,안영주 대한소화기내시경학회 1993 Clinical Endoscopy Vol.13 No.1
Angiodysplasia of the small bowel is an uncommon disorder in Korea, and is often found to be the cause of unexplained gastrointestinal bleeding. A 53-year-old male patient visited an emergeney room because of repeated melena and dizziness, He underwent selective superior mesenteric arterial angiography which revealed abnormal clusters of small arteries and early opacification of veins draining a segment of lower jejunum. An exploratory laparotomy was performed under the impression of angiodysplasia. An ulceration on the lower jejunum was found, and was resected. Subsequent jejunojejunostomy was performed. Histology of the resected specimen showed an irregularly dilated vessels in mucosa and submucosa.