케톤형성 식이요법으로 인해 발생한 색소침착가려움발진 2예

양나경,김재윤,은윤수,이성열,정의현,이현주,김정은 대한피부과학회 2022 大韓皮膚科學會誌 Vol.60 No.9

Prurigo pigmentosa (PP) is a rare inflammatory skin disease that commonly affects Asian women. It is characterizedby symmetric pruritic eruptions in a reticular pattern, primarily on the back, chest, or neck. The etiology of PP isunclear; however, it is estimated that neutrophil-mediated inflammation of the skin is induced by various exogenousstressors, such as friction from clothing and sweating. In addition to exogenous factors, some cases are thought tobe related to ketosis, diabetes mellitus, fasting, or dieting to lose weight. With the increasing popularity of ketogenicdiets, cases of PP are being more commonly reported. To raise awareness of this disease, we present two cases ofPP that occurred after following a ketogenic diet.

코로나바이러스감염증-19 백신 접종 후 발생한 결절 홍반

양나경,홍정연,김재윤,이성열,김정은,유시내,정의현 대한피부과학회 2022 대한피부과학회지 Vol.60 No.6

Erythema nodosum (EN) is the most common form of panniculitis and may be triggered by a variety of stimuli, including infections, drugs, pregnancy, sarcoidosis, inflammatory bowel disease, and malignancies. Rare cases of vaccination-related EN have been reported, but none due to the coronavirus disease 2019 (COVID-19) vaccine of Pfizer have been documented. We report a case of EN associated with the Pfizer vaccine. A 43-year-old woman presented with acute-onset painful nodular lesions that appeared bilaterally on the extensor surface of the lower legs. These lesions appeared 5 days after the first dose of Pfizer vaccination. The patient reported no recent infectious history other than fever for 3 days after vaccination. Skin biopsy revealed inflammation extending into the subcutaneous fat with a septal distribution. It is important for physicians to be aware of the side effects of the COVID-19 vaccine because more people are bound to be vaccinated. (Korean J Dermatol 2022;60(6):383∼386)

모바일 웹 기반 코로나19 격리 입원관리 교육이 환자의 불확실성, 불안 및 간호교육 만족도에 미치는 효과

양나경,서지영 병원간호사회 2022 임상간호연구 Vol.28 No.2

Purpose: This study aims to identify the effects of mobile web-based COVID-19 isolation hospitalization management training on patient‘s uncertainty, anxiety, and nursing education satisfaction. Methods: Patients hospitalized with COVID-19 isolation rooms from August to October 2021, in Medical Center B which is an infectious disease dedicated hospital located in metropolitan city B were included. The total number of subjects was 142, of which 71 were the experimental group and 71 the control group. As an experimental treatment, a total of 5 minutes and 35 seconds of mobile web-based education were provided to the experimental group three times, including the day of, the first day of, and the second day of hospitalization. Existing training conducted on the control group was provided by the nurses in charge of the ward through oral explanation using printed materials. The data were analysed using the IBM SPSS/WIN 26.0 program. Results: Significant differences were observed between the two groups in pre- and post-assessment of uncertainty scores (t=-22.92,p<.001), anxiety scores (t=-15.03,p<.001) and nursing education satisfaction score (t=11.61, p<.001). Conclusion: As a result of the above, mobile web-based education can be used as an effective educational medium in nursing practice to improve the work efficiency and quality of nursing care and contribute to improving the patient's educational satisfaction. 목적 : 본 연구는 모바일 웹 기간 코로나19 격리 입원관리 교육이 환자의 불확실성, 불안 및 간호교육 만족도에 미치는 효과를 확인하기 위함이다. 방법 : 2021년 8월부터 10월까지 B광역시에 소재한 감염병 전담병원인 B의료원 격리병실에 코로나19로 입원한 환자들 중 연구의 목적을 이해하고 연구 참여에 자발적으로 동의한 환자를 대상으로 하였다. 대상자 수는 실험군 71명, 대조군 71명으로 총 142명을 대상으로 하였다. 실험처치로 실험군에게 총 5분 35초의 모바일 웹 기반 교육을 입원당일, 입원 1일째, 입원 2일째 총 3회 제공하였고 대조군에게 제공한 기존 교육은 인쇄물을 이용한 구두 설명을 통해 제공하였다. 자료분석은 SPSS/WIN 26.0 program을 이용하였다. 결과 : 실험군과 대조군은 불확실성(t=-22.92, p<.001), 불안(t=-15.03, p<.001), 간호교육 만족도(t=11.61, p<.001)에 유의한 차이가 있었다. 결론 : 이상의 결과로 모바일 웹 기반 교육은 간호사의 업무 효율과 질을 향상시키고 간호 업무에 기여하는 효과적인 교육 매체로 사용될 수 있을 것이다.

건선 환자에서 발생한 간질성 폐질환 1예

김재윤,양나경,은윤수,이휘인,정의현,이성열,김정은 대한건선학회 2023 대한건선학회지 Vol.20 No.1

Patients with psoriasis may be accompanied by various systemic comorbidities, including lung diseases, and it is crucial to manage them. Interstitial lung disease is occasionally reported in patients with psoriasis secondary to the use of immunosuppressants in most cases. A 54-year-old woman, who had a history of psoriasis for 2 years but had never used immunosuppressant or biologics, presented with cough and dyspnea that started 6 months ago. She was diagnosed with interstitial lung disease on chest X-ray and chest CT, and oral steroid was used. The interstitial lung disease responded to oral steroid treatment for one year, but psoriasis lesions became worse after discontinuing oral steroids. She is currently being treated with narrowband ultraviolet B (NBUVB) therapy and calcipotriol/betamethasone topical gel. Herein, we report a rare case of interstitial lung disease in psoriasis patient.

크론병 환자에서 Infliximab 치료 중 발생한 물방울 모양 건선 1예

김재윤,은윤수,양나경,정의현,이성열,김정은 대한건선학회 2022 대한건선학회지 Vol.19 No.2

Infliximab (IFX) is a monoclonal antibody designed to neutralize tumor necrosis factor alpha (TNF-) and administration of IFX is very effective in treating moderate to severe Crohn’s disease. A 25-year-old man with a history of Crohn’s disease for 2 years presented with erythematous scaly papules on his trunk and both arms since 4 months ago. He has been treated with IFX for Crohn’s disease during the last 8 months and had no previous history of psoriasis. Empirically, the lesions responded to narrowband ultraviolet B (NBUVB) therapy and topical betamethasone and calcipotriol treatment. Through skin biopsy, the patient was diagnosed with guttate psoriasis. Herein, we report a rare case of guttate psoriasis during IFX treatment.

제조업과 서비스업 융합이 제조업 생산에 미치는 영향

이동희,고대영,양나경 한국응용경제학회 2018 응용경제 Vol.20 No.2

본 연구는 생산기술구조의 융합 관점에서 제조업과 서비스업간 연계수준을 정량적으로 측정하여 네트워크로 시각화하고, 관련된 융합도가 제조업 생산에 미치는 영향을 분석하였다. 주요한 분석결과로 첫째, 제조업과 지식집약사업서비스(KIBS) 간의 강한 연계는 전반적으로 제조업의 생산에 긍정적인 영향을 미친다. 둘째, 융합의 효과는 제조업 기술수준과 세부 KIBS 분야에 따라 달라진다. 중고위기술 제조업의 생산에는 과학기술전문서비스, 사업전문서비스, 연구개발과의 융합이 긍정적인 영향을 끼치지만, 중저위․저위기술 제조업의 경우 연구개발 및 정보통신서비스와의 융합은 부정적인 것으로 분석됐다. 셋째, 제조업과 KIBS간 연계⋅융합은 지역별로 이질적인 영향을 미친다. 이는 지역마다 산업구조 및 주력제조업이 이질적이기 때문에 발생한 결과로 해석된다. 따라서 제조업에 대한 서비스 중간투입 확대정책을 수립함에 있어 제조업의 기술수준을 고려하여 적합한 KIBS와의 융합을 촉진할 필요가 있다. From a convergence perspective of production technology structure, this study measured the level of linkage between manufacturing and service industries and analyzed the effect of convergence on manufacturing production. As main findings, firstly, the strong linkage between manufacturing and knowledge-intensive business services (KIBS) mostly has a positive impact on the manufacturing production. Secondly, the effect of convergence depends on the technology level of manufacturing and the sub-industries of KIBS. Thirdly, the impact of convergence between manufacturing and KIBS is heterogeneous across regions. Therefore, manufacturing-service convergence should be pursued by considering the technology level of manufacturing and the sub-industries of KIBS.

스티븐스 존슨 증후군 및 독성표피괴사융해증 88예의 임상적 고찰

홍정연 ( Jeong Yeon Hong ),정의현 ( Euy Hyun Chung ),양나경 ( Na Gyeong Yang ),김재윤 ( Jae Yun Kim ),허남훈 ( Nam Hun Heo ),이설희 ( Sul Hee Lee ),김정은 ( Jung Eun Kim ),이성열 ( Sung Yul Lee ) 대한피부과학회 2021 대한피부과학회지 Vol.59 No.8

Background: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are potentially fatal acute hypersensitivity reactions that involve the skin and mucous membranes. Because they are relatively rare diseases, it is difficult to obtain well-organized epidemiological data. The clinicodemographic characteristics, culprit drugs, and factors related to disease prognosis may vary. Objective: To identify the characteristics of SJS/TEN by investigating patient clinicopathological characteristics, laboratory findings, suspected drugs, and mortality through a retrospective study using medical record data. Methods: The clinical records of patients diagnosed with SJS/TEN between February 2009 and February 2019 at three medical institutions of Soonchunhyang University were retrospectively reviewed. Data pertaining to sex, age, history, suspected drugs, latent period, laboratory findings, and mortality were collected, and their correlations were analyzed. Results: We identified SJS/TEN in 88 patients. Among the probable causative agents, antibiotics were the most common (29 cases, 33.0%), followed by nonsteroidal anti-inflammatory drugs (NSAIDs) in 20 cases (22.7%). The period between drug administration and symptom onset varied with the causative agent. Patients who died had high SCORTEN scores. In addition, hypertension, diabetes, renal failure, and cardiac disease had a statistically significant association with high SCORTEN. Conclusion: Antibiotics, NSAIDs, antiepileptics and allopurinol were the most commonly implicated drugs in our retrospective study. There was a significant correlation between comorbidities. Because SJS/TEN is a life-threatening condition, early recognition of the suspected drug are important. The results of this study may provide insights that aid in the early diagnosis and prediction of disease outcomes of SJS/TEN in the Korean population. (Korean J Dermatol 2021;59(8):604∼610)