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청목향 Aristolochiae radix에 있어 F344 랫드의 독성
김충용,김용범,양병철,이종화,정문구,양기화,장동덕,한상섭,강부현,Kim, Choong-Yong,Kim, Yong-Bum,Yang, Byung-Chul,Lee, Jong-Hwa,Chung, Moon-Koo,Yang, Ki-Hwa,Jang, Dong-Deuk,Han, Sang-Seop,Kang, Boo-Hyon 대한수의학회 2005 大韓獸醫學會誌 Vol.45 No.1
13-week orally repeated dose toxicity was investigated to ascertain the toxic effects of Aristolochiae radix in F344 rats at dose levels of 0, 1 (0.003 AA, aristolochic acid, mg/kg), 5 (0.014 AA mg/kg), 25 (0.068 AA mg/kg), 125 (0.34 AA mg/kg), and 500mg/kg (AA 1.36 mg/kg). No mortalities were found in any of the dose groups including vehicle control groups of both sexes during the study period. Hematologic and serum biochemical examinations revealed no changes related to the test item in any of the dose groups of both sexes. However, gross findings at necropsy implicated thickening of the stomach wall. In histopathological examinations, prominent findings related to the test item treatment were observed in the stomach and urinary bladder. There were squamous cell papilloma, squamous cell hyperplasia, ulceration and erosion observed in the non-glandular stomach. Squamouse cell hyperplasia was observed at dose levels of more than 125 mg/kg in both sexes and squamous cell papilloma was observed at dose level of 500 mg/kg in both sexes. The incidence and severity of these proliferating lesions including squamous cell hyperplasia and squamous cell papilloma increased with dose dependency. Transitional cell hyperplasia was also observed in the urinary bladder at dose levels of more than 25 mg/kg in both sexes and the incidence and severity of the lesion increased with dose dependency. In conclusion, the toxic changes related to the test item treatment were observed in the stomach and urinary bladder, and the no-observed-adverse-effect level (NOAEL) was estimated to be 5 mg/kg/day for both males and females in F344 rats.
척수팽대와 낭종을 동반한 척수-연수 연접부의 혈관아세포종 - 증례보고 -
박성진,정호,이상걸,박문선,하호균,양기화,Park, Sung-Jin,Jung, Ho,Lee, Sang-Keol,Park, Moon-Sun,Ha, Ho-Gyun,Yang, Ki-Hwa 대한신경외과학회 2000 Journal of Korean neurosurgical society Vol.29 No.6
Hemangioblastoma of the central nervous system rarely occurs in cervicomedullary junction. The unique pathologic features of the tumor involving midline structures are grossly solid in consistency and accompanying extensive spinal cord enlargement. A 63-year-old women presented with progressive right motor weakness and tingling sensation. The MR image showed a well enhancing mass having a cyst and diffuse cord enlargement in the cervicomedullary junction. A total surgical resection was performed and hemangioblastoma was histologicaly verified. Postoperative MR image showed the disappearance of cord enlargement. The right motor weakness was also improved. The authors report a rare case of hemangioblastoma in cervicomedullary junction and the pathophysiology of the spinal cord enlargement are discussed.
Indole-3-carbinol(I3C) 투여에 의한 7,12-Dimethylbenz[α] anthracene(DMBA) 유발 랫드 유선발암 억제
강진석,안병우,남기택,최미나,김지영,김대중,장동덕,양기화,Kang, Jin Seok,Ahn, Byeongwoo,Nam, Ki Taek,Choi, Mina,Kim, Ji Young,Kim, Dae Joong,Jang, Dong Deuk,Yang, Ki-Hwa 대한수의학회 2001 大韓獸醫學會誌 Vol.41 No.4
Indole-3-carbinol (I3C), one component of cruciferous vegetables (the Fammily of Cruciferae), has been shown to exert its chemopreventive effect in liver, colon and mammary tissue before or concurrent exposure of carcinogen, but there have been several evidences that consumption of I3C induced tumor promotion in some tissues. Our studies were investigated to examine the modifying effects of I3C in the 7,12-dimethylbenz[$\alpha$]anthracene (DMBA) induced rat mammary gland tumor model. Fifty-two female Sprague-Dawley rats were randomly divided into five groups. Animals of the group 1 were given the diet containing 100ppm I3C and animals of the groups 2 and 4 were given the diet containing 300ppm I3C from 6 weeks of age. At 7 weeks of age, the animals of the groups 1, 2 and 3 were intubated with DMBA. All amimals were killed at 20 weeks after carcinogen treatment. There were significant increases of food consumption in I3C feeding groups compared with those of basal diet feeding groups. The incidences of the mammary tumors in the group 1, 2 and 3 were 75.0% (9/12), 56.3% (9/16) and 93.8% (15/16), respectively and the average number of tumors of group 1 (DMBA+I3C 100ppm: $2.08{\pm}0.61$) and 2 (DMBA+I3C 300ppm: $1.19{\pm}0.32$) were significantly lower than that of group 3 (DMBA alone: $4.63{\pm}0.72$) at the value of P<0.05 and P<0.001, respectively. In the pathological examination of appearing tumors, most of them were adenocarcinoma. Many epithelial cells of tumors showed strong estrogen receptor (ER) $\alpha$ expression but there were slight difference of ER $\alpha$ expression among the type of tumors. We suggest that pre-initiation treatment of I3C has an inhibitory effects on mammary carcinogenesis induced by DMBA.
랫드에서 계피유래활성물질(CB-PH)의 경구투여에 의한 4주간 반복투여독성 시험
조현무(Hyun-Mu Jo),성낙원(Nak-Won Seong),제정환(Jung Hwan Che),박기대(Ki Dae Park),남기택(Ki Taek Nam),조완섭(Wan-Seob Cho),한범석(Beom Seok Han),양기화(Ki Hwa Yang),김방현(Bang Hyun Kim),이국경(Kook Kyung Lee),김형진(Hyoung-Chin Kim 한국독성학회 2003 Toxicological Research Vol.19 No.4
Although 'Cinnamon' has been widely used for the food and biophamacy in the world, it's toxicity was not screened completely. Major component of 'cinnamon' is CB-OH and CB-PH. CBPH has been reported to have antimutagenic effect. To investigate the toxicity of 2- o-Benzoylcinnamaldehyde (CB-PH), repeated dose (4 weeks) oral toxicity test performed in SD rats. Results of repeated dose oral toxicity tests for 4 weeks (CB-PH; 500, 1000, 2000 mg/kg/day) suggested that the CB-PH treated group showed no significant toxicological findings with body weights, organ weights, hematological and histopathological findings. Therefore, these data indicated that the maximum tolerated dose of CB-PH was 2000 mg above/kg/day in the rats.
갑상선 질환에서 혈청 Microsome 항체 측정의 의의
윤영옥 ( Young Ok Yoon ),장순모 ( Soon Mo Chang ),박호자 ( Ho Ja Park ),이준옐 ( Jun Yoel Lee ),양기화 ( Ki Hwa Yang ),정인숙 ( In Sook Chung ),강석진 ( Seok Jin Gang ) 대한임상검사과학회 1984 대한임상검사과학회지(KJCLS) Vol.16 No.1
Since Roitt and his associates discovered antithyroglobulin antibody in serum of the patient with Hashimoto`` s thyroiditis, in 1956, several anti-thyroid autoantibodies were discovered, and have been attributed to the diagnosis of thyroid disease. The authors investigated the incidence and titers of antimicrosomal antibody in the 515 patients with various thyroid disease from October, 1981 to December, 1983, and 104 normal healthy persons, measured by tanned red cell hemagglutination technic. 1) Twenty healthy males were all negative, and ten (11.9%) out of eighty-four healthy female were positive. 2) The disease group with high positive rate included Graves`` disease; 222 cases (91.4%) out of 243 cases, Hashimoto``s disease; 112 cases (92.6%) out of 121 cases, all eight cases of postpartum thyroiditis. 3) The disease group with low positive rate included non-toxic nodular goiter; 14 cases (17.5%) out of 80 cases, non-toxic diffuse goiter; 11 cases (31.4%) out of 35 cases, thyroid tumor; 2 cases (11.1%) out of 18 cases, subacute thyrolditis; 3 cases (30%) out of 10 cases. 4) In 32 cases of Graves`` disease that were follow up more than three times, the titers of anti-microsomal antibody reveal marked fluctuation. In summary, although the positive rate of the anti-microsomal antibody in the Graves disease, Hashimoto``s disease and postpartum thyroiditis, reveal diagnostic significance, the titer of the anti-microsomal antibody which examine in one point, cann`t contribute to reflect the severity of the disease, because of the titer is fluctuated during the course of the disease.
독성병리 Peer Review의 중요성과 실제적 접근방법
손우찬(Woo-Chan Son),김배환(Bae-Hwan Kim),장동덕(Dong-Deuk Jang),한범석(Beom-Seok Han),양기화(Ki-Hwa Yang),이영순(Yong-Soon Lee) 한국독성학회 2004 Toxicological Research Vol.20 No.1
Evaluation of toxicological pathology is to some extend subjective judgments by pathologist and the accuracy of pathologist’s works is based on the individual training and experiences. It has been required to establish a peer review system for toxicologic pathology and these review system has been employed by various practice of toxicological pathology. It would be pointed out that the possible causes of drifts in pathology are due to 1) lack of knowledge or experience of individual pathologists, 2) poorly maintained consistence of grading among animals in study, 3) different interpretation of findings between pathologists, or 4) pathology data processing. Example cases of diagnostic errors and current practice of peer review including tissue selection criteria, documentation and problem resolution for short-term and carcinogenicity studies were introduced. For sound regulatory<br/> system and high integrity of practice in toxicological pathology, current approaches of peer review system were reviewed.
Mycoplasma pulmonis의 LAMP를 이용한 ELISA 법 개발
김동재(Dong-Jae Kim),박종환(Jong-Hwan Park),석승혁(Seung-Hyeok Seok),조선아(Sun-A Cho),백민원(Min-Won Baek),이희영(Hui-Young Lee),장동덕(Dong Deuk Jang),양기화(Ki-Hwa Yang),한범석(Beom-Seok Han),박재학(Jae-Hak Park) 한국실험동물학회 2004 Laboratory Animal Research Vol.20 No.3
Mycoplasma pulmonis infection causes chronic respiratory disease and decreases reproductive efficiency. Infected mice display inactivity, weight loss, and ruffled hair coat, but the most prominent signs are "chattering" and dyspnea, due to rhinitis and purulent exudate in nasal passages. In this study we developed the ELISA method for M. pulmonis using LAMP (Lipid-Associated Membrane Protein) of Mycoplasma pulmonis. We isolated M. pulmonis from bronchial flushing fluid of conventionally housed mice and rats. The LAMP of isolated M. pulmonis is used in ELISA antigen development The results of serological test, in the ELISA with LAMP of M. pulmonis, were equal to those of a commercial ELISA kit. Our ELISA method will be used to eradicate Mycoplasma pulmonis infection in laboratory animal facilities and contribute to quality control of laboratory animals.