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항염작용을 갖는 신규 생약복합제 SKI306X의 분리 및 항염작용
박광식(Kwang Sik Park),김환수(Hwan Su Kim),안재석(Jea Suk Ahn),김택수(Taek Soo Kim),박병욱(Pyeong Uk Park),곽의종(Wie Jong Kwak),한창균(Chang Kyun Han),조용백(Yong Baik Cho),김기협(Key H. Kim) 대한약학회 1995 약학회지 Vol.39 No.4
Antiinflammatory activities of the solvent fractionates of several herbal medicines were investigated and SKI306X was prepared from the active principles of three herbal medicines, Prunella vulgaris, Trichosanthes kirilowii and Clematis mandshurica. SKI306X was shown to have strong inhibitory effects on acetic acid-induced pain, carrageenan-induced paw edema and adjuvant-induced arthritis. LD50 of SKI306X was more than 5g/kg in rat, so generally nontoxic. Chemical analysis revealed that oleanolic acid and rutin, which are known to have various antiinflammatory activities, were contained in it. These results suggest SKI306X may become a useful drug for the treatment of inflammatory diseases such as rheumatoid arthritis.
고광호(Kwang Ho Ko),조미정(Mi Jeong Jo),이장훈(Jang Hoon Lee),노민수(Min Su Noh),류재련(Jea Ryeon Ryu),이진화(Jin Hwa Lee),안재석(Jae Suk Ahn),태주호(Joo Ho Tai),민동선(Dong Sun Min),박병욱(Pyeong Uk Park),김기협(Key Hyup Kim) 한국응용약물학회 1994 Biomolecules & Therapeutics(구 응용약물학회지) Vol.2 No.1
Anti-inflammatory and analgesic activities and skin irritation of piroxicam patch were investigated. Piroxicam patch increased the pain threshold in rat hind paw inflamed by carrageenan and inhibited writhing induced by acetic acid in mice. Piroxicam patch also inhibited the carrageenan-induced edema in rat hind paw as well as the increased vascular permeability induced by histamine in rats. In adjuvant arthritis of rats, piroxicam patch showed anti-inflammatory effects. Skin irritation of piroxicam patch was tested in Newzealand White rabbits and evaluated by Primary Irritation Index of Draize. The results from skin irritation test showed that piroxicam patch seemed practically non-irritating. The result from the present study indicates that piroxicam may be useful without serious side effects as anti-inflammatory analgesics in this patch form.